Polysaccharides based superabsorbent hydrogel from Linseed: Dynamic swelling, stimuli responsive on–off switching and drug release

Haseeb, Muhammad Tahir; Hussain, Muhammad Ajaz; Yuk, Soon Hong; Bashir, Sajid; Nauman, Muhammad

doi:10.1016/j.carbpol.2015.09.092

Cited by 91 publications

(50 citation statements)

References 27 publications

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“…38 Linseed (100 g) was thoroughly washed with deionized water to clean it from dust particles and soaked overnight in deionized water (1,000 mL). The swollen seeds were heated at 80°C for 30 min under stirring.…”

Section: Isolation Of Lshmentioning

confidence: 99%

Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications

Haseeb¹,

Hussain²,

Abbas³

et al. 2017

IJN

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Polysaccharides are being extensively employed for the synthesis of silver nanoparticles (Ag NPs) having diverse morphology and applications. Herein, we present a novel and green synthesis of Ag NPs without using any physical reaction conditions. Linseed hydrogel (LSH) was used as a template to reduce Ag + to Ag 0 . AgNO 3 (10, 20, and 30 mmol) solutions were mixed with LSH suspension in deionized water and exposed to diffused sunlight. Reaction was monitored by noting the change in the color of reaction mixture up to 10 h. Ag NPs showed characteristic ultraviolet-visible (UV/Vis) absorptions from 410 to 437 nm in the case of sunlight and 397–410 nm in the case of temperature study. Transmission electron microscopy images revealed the formation of spherical Ag NPs in the range of 10–35 nm. Face-centered cubic array of Ag NPs was confirmed by characteristic diffraction peaks in powder X-ray diffraction spectrum. Ag NPs were stored in LSH thin films, and UV/Vis spectra recorded after 6 months indicated that Ag NPs retained their texture over the storage period. Significant antimicrobial activity was observed when microbial cultures (bacteria and fungi) were exposed to the synthesized Ag NPs. Wound-healing studies revealed that Ag NP–impregnated LSH thin films could have potential applications as an antimicrobial dressing in wound management procedures.

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Section: Isolation Of Lshmentioning

confidence: 99%

Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications

Haseeb¹,

Hussain²,

Abbas³

et al. 2017

IJN

Self Cite

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“…Understanding hydrogel swelling is critical for drug release applications or stress dissipation mechanisms in articular cartilage. [ 75–77 ] Figure shows the minimal impact that each of the top performing additives had on the ability of the hydrogel to swell in deionized water at room temperature according to the procedure described in Hydrogel Swelling of the Experimental Section.…”

Section: Introduction Of Synthetic Hydrogelsmentioning

confidence: 99%

Tensile Fatigue of Poly(Vinyl Alcohol) Hydrogels with Bio‐Friendly Toughening Agents

Koshut

Smoot

Rummel

et al. 2020

Macro Materials & Eng

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Inspired by the avoidance of toxic chemical crosslinkers and harsh reaction conditions, this work describes a poly(vinyl alcohol)‐based (PVA) double‐network (DN) hydrogel aimed at maintaining biocompatibility through the combined use of bio‐friendly additives and freezing–thawing cyclic processing for the application of synthetic soft‐polymer implants. This DN hydrogel is studied using techniques that characterize both its chemical and mechanical behavior. A variety of bio‐friendly additives are screened for their effectiveness at improving the toughness of the PVA hydrogel system in monotonic tension. Starch is selected as the best additive for further tensile testing as it brings about a near 30% increase in ultimate tensile strength and maintains ease of processing. This PVA–starch DN sample is then studied for its tensile fatigue properties through cyclic, strain‐controlled testing to develop a fatigue life curve. Though an increase in monotonic tensile strength is observed, the PVA–starch DN hydrogel does not bring about an improvement in the fatigue behavior as compared to the control. Although synthetic hydrogel reinforcement is widely researched, this work presents the first fatigue analysis of its kind and it is intended to serve as a guide for future fatigue studies of reinforced hydrogels.

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“…BSH was isolated from the seeds of O. basilicum as reported elsewhere with some modification [3,4,10]. Briefly, seeds of O. basilicum (50 g) were soaked in deionized water (1000 mL) for 4 h before warming at 40 ∘ C for 45 min.…”

Section: Isolation Of Bshmentioning

confidence: 99%

“…Physical properties of BSH, such as bulk density, tapped density, particle size, angle of repose, Hausner ratio, and Carr's index, were determined. Moisture content, water retention capacity, gelation contents, and swelling capacity of hydrogel were also determined [10].…”

Section: Physical Properties Of Bshmentioning

confidence: 99%

“…Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic. Recently, polysaccharide-based hydrogels have gained a lot of interest in drug delivery system due to their extraordinary swelling indices, stimuli responsive properties, biodegradability, biocompatibility, and nontoxicity [9][10][11][12][13].Ocimum basilicum L., (Syn: sweet basil in English, Babui tulsi in Hindi and Marathi, Rihan in Arabic, Niasabo in Gujrati, Jangli tulsi in Urdu, Tohrakhurasani in Persian, and Okimon in Unani) is a popular culinary and ornamental herb…”

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confidence: 99%

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Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Lodhi

Hussain

Sher

et al. 2019

Advances in Polymer Technology

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This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water. Highly reversible on-off switching (swellingdeswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline. Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of BSH having average pore size of 1.92 ± 3.83 m noted after swelling and lyophilization. BSH containing tablet formulations showed a sustained release pattern of diclofenac sodium (DS) which is dependent on the concentration of BSH. When comparing with commercially available formulation of DS, even better sustained release behavior of DS was observed in BSH-based formulation. Super case-II transport mechanism is followed by the DS release from BSH matrix tablet. Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic. Recently, polysaccharide-based hydrogels have gained a lot of interest in drug delivery system due to their extraordinary swelling indices, stimuli responsive properties, biodegradability, biocompatibility, and nontoxicity [9][10][11][12][13].Ocimum basilicum L., (Syn: sweet basil in English, Babui tulsi in Hindi and Marathi, Rihan in Arabic, Niasabo in Gujrati, Jangli tulsi in Urdu, Tohrakhurasani in Persian, and Okimon in Unani) is a popular culinary and ornamental herb

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Polysaccharides based superabsorbent hydrogel from Linseed: Dynamic swelling, stimuli responsive on–off switching and drug release

Cited by 91 publications

References 27 publications

Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications

Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications

Tensile Fatigue of Poly(Vinyl Alcohol) Hydrogels with Bio‐Friendly Toughening Agents

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

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