Polysaccharides as potential antioxidative compounds for extended-release matrix tablets

Tomida, Hisao; Yasufuku, Taira; Fujii, Takeshi; Kondô, Yûkô; Kai, Toshiya; Anraku, Makoto

doi:10.1016/j.carres.2009.10.015

Cited by 48 publications

(24 citation statements)

References 28 publications

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“…Sen (2011) reported that low molecular weight alginate (20.5 kDa) with a lower ratio of guluronic acid to mannuronic acid exhibited a better α,α-diphenyl-β-picryl-hydrazyl (DPPH) scavenging activity. Tomida et al (2010) also found that low molecular weight alginate (941.5 kDa) had better scavenging ability on DPPH and ABTS than alginate with molecular weight of 2,695.1 kDa. However, antioxidant activity of alginate with molecular weight below 10 kDa has never been reported.…”

Section: Introductionmentioning

confidence: 92%

Effect of molecular weight on the antioxidant property of low molecular weight alginate from Laminaria japonica

Zhao

Xue

et al. 2011

J Appl Phycol

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In this study, three alginate fractions with different molecular weights and ratios of mannuronic acid (M) to guluronic acid (G) were prepared by enzymatic hydrolysis and ultrafiltration to assess the antioxidant property of alginates from Laminaria japonica with molecular weight below 10 kDa. The antioxidant properties of different molecular weight alginates were evaluated by determining the scavenging abilities on superoxide, hydroxyl, and hypochlorous acid and inhibitory effect on Fe 2 + -induced lipid peroxidation in yolk homogenate. The results showed that low molecular weight alginates exhibited high scavenging capacities on superoxide, hydroxyl, and hypochlorous acid radicals and good inhibition of Fe 2+ -induced lipid peroxidation in yolk. By comparison, alginate A1 with molecular weight below 1 kDa and M/G of 1.84 had better scavenging activity on superoxide, hydroxyl, and hypochlorous acid radicals in vitro than A2 (1-6 kDa), A3 (6-10 kDa), ascorbic acid, and carnosine. With similar M/G ratio, A2 exhibited better antioxidant activity on superoxide and hypochlorous acid radicals than A3. However, fraction A3 with molecular weight of 6-10 kDa exhibited higher inhibitory ability on lipid peroxidation in yolk in vitro than A1 and A2. The results indicated that molecular weight played a more important role than M/G ratio on alginate to determine the antioxidant ability. By comparison, low molecular weight alginates composed of guluronic acid and mannuronic acid exhibited better antioxidant ability on oxygen free radicals than sulfated polysaccharides from L. japonica in our previous study and represent a good source of marine polysaccharide with potential application as natural antioxidant.

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Section: Introductionmentioning

confidence: 92%

Effect of molecular weight on the antioxidant property of low molecular weight alginate from Laminaria japonica

Zhao

Xue

et al. 2011

J Appl Phycol

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“…Despite the high cross-linking efficiency derived from HR-MAS 1 H NMR spectroscopy, Alg-Gel samples show lower storage moduli compared to Gel-MOD. It has been indicated in literature that different polysaccharides including alginate, can act as radical scavengers [29]. This could lead to shorter poly(methacrylate) bridges and thus a lower amount of gelatin chains being linked together, effectively lowering the mechanical properties.…”

Section: Rheological Evaluation Of Hydrogel Filmsmentioning

confidence: 99%

Cross-linkable alginate-graft-gelatin copolymers for tissue engineering applications

Graulus

Mignon

Vlierberghe

et al. 2015

European Polymer Journal

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a b s t r a c tWhen it comes to failing or injured tissues and organs, patients often end up on waiting lists for tissue or even organ transplantation negatively affecting the patient's quality of life. The multidisciplinary research field of tissue engineering may offer more innovative ways to replace or ideally regenerate failing tissues and organs. A widely used material in this research field is gelatin because of its biocompatibility and interesting hydrogel forming properties. However, at body temperature gelatin's mechanical properties are greatly reduced due to the dissolution of collagen-like triple helices. With the aim to obtain materials that retain their mechanical properties at body temperature, we propose to combine sodium alginate and methacrylamide-modified gelatin (Gel-MOD) in the form of a graft copolymer to obtain a material that closely resembles the extracellular matrix. The obtained materials can be cross-linked via three distinct pathways including cation mediated, temperature mediated or via covalent bond formation after UV irradiation in the presence of a photo-initiator. The current contribution covers the synthesis of the above mentioned alginate-graft-gelatin copolymers and the characterization of the resulting hydrogels. The materials developed are highly hydrophilic, showing high gel fractions and satisfactory mechanical properties. Moreover the attained storage moduli were tunable by divalent cation addition (72-275% increase at 21°C, 42-405% increase at 40°C). One formulation was found to outperform Gel-MOD in terms of mechanical properties at 40°C, thus indicating the proposed strategy can be used to improve the mechanical properties of gelatin-based hydrogels. Moreover, in vitro biocompatibility assays indicated that cell adhesion and proliferation improves with increasing gelatin content. The present paper illustrates that the developed triple cross-linkable materials are suitable cell carriers, promising to be applied for biomedical purposes.

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“…In recent years, considerable attention has directed to marine algae as a rich source of polysaccharides with antioxidant activity (Qi et al, 2005). In addition to the biological activities of alginate polymers and their oligomers described above, recent studies have demonstrated that alginate oligomers (Wang et al, 2007) as well as polymers (Tomida et al, 2010) show potent antioxidant activities. It is well known that hydroxyl radical is the most ROS that can react with various biological molecules, and damaging effect on various biological systems is the strongest among the ROS (Aruoma, Kaur, & Halliwell, 1991;Millic, Dijilas, & Canadanovic-Brunet, 1998).…”

Section: Antioxidant Activities Of Alginatementioning

confidence: 99%

“…Several studies on the effects of alginates on physiological activities of plant cells have been reported Aoyagi, Sakamoto, Asada, & Tanaka, 1998;Aoyagi, Yasuhira, & Tanaka, 1999;Tanaka, Kaneko, Aoyagi, Yamamoto, & Fukunaga, 1996;Tanaka, Yamashita, Aoyagi, Yamamoto, & Fukunaga, 1996;Tomida et al, 2010). Several studies on the effects of alginates on physiological activities of plant cells have been reported Aoyagi, Sakamoto, Asada, & Tanaka, 1998;Aoyagi, Yasuhira, & Tanaka, 1999;Tanaka, Kaneko, Aoyagi, Yamamoto, & Fukunaga, 1996;Tanaka, Yamashita, Aoyagi, Yamamoto, & Fukunaga, 1996;Tomida et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Biological Activities of Alginate

Ueno

Oda

2014

Advances in Food and Nutrition Research

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Polysaccharides as potential antioxidative compounds for extended-release matrix tablets

Cited by 48 publications

References 28 publications

Effect of molecular weight on the antioxidant property of low molecular weight alginate from Laminaria japonica

Effect of molecular weight on the antioxidant property of low molecular weight alginate from Laminaria japonica

Cross-linkable alginate-graft-gelatin copolymers for tissue engineering applications

Biological Activities of Alginate

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