Polysaccharides as Potential Anti-tumor Biomacromolecules —A Review

Lilii Bulbus, an edible Chinese herbal medicine, has a long history in medicine. However, research on effectively boiling Lilii Bulbus is rare. To make the more nutritious Lilii Bulbus soup, the optimized boiling process, using an alternate heating mode by decoction pot carrying a mixture of water and Chinese liquor at the ration of 9:1, was established in this study. Compared to the soup prepared by the daily process, the polysaccharide amount improved by 54%, and the total heavy metals decreased by 33.5% using the optimized boiling process. In addition, the total saponins at 34.3 μg/g were determined in the soup prepared by the optimized process. Meanwhile, the colchicine content in the boiled Lilii Bulbus soup was undetectable using the optimized process. This research performs an optimized boiling process for making Lilii Bulbus soup, and provides a reference for generating high commercial value from Lilii Bulbus soup in the future.

Section: Resultsmentioning

confidence: 99%

Section: Effects Of Different Boiling Processes On Total Polysacchari...mentioning

confidence: 99%

Effects of different boiling processes on chemical compositions of Lilii Bulbus soup

Liu

Chen

et al. 2022

“…Polysaccharides possessing sulfur and uronic acids displayed antioxidant potential and anti-cancer properties by restoring cell redox control ( 100 , 101 ). The most prevalent mechanisms of anti-tumor polysaccharides are cell cycle arrest, anti-angiogenesis, and apoptosis, all of which have direct tumor-killing abilities ( 102 ). Polysaccharide anti-tumor action is determined by the main chain configuration ( 103 ).…”

Section: Prebiotic Properties Of Microbial Polysaccharidesmentioning

confidence: 99%

Bacterial polysaccharides—A big source for prebiotics and therapeutics

Khan

Shah

et al. 2022

Bacterial polysaccharides are unique due to their higher purity, hydrophilic nature, and a finer three-dimensional fibrous structure. Primarily, these polymers provide protection, support, and energy to the microorganism, however, more recently several auxiliary properties of these biopolymers have been unmasked. Microbial polysaccharides have shown therapeutic abilities against various illnesses, augmented the healing abilities of the herbal and Western medicines, improved overall health of the host, and have exerted positive impact on the growth of gut dwelling beneficial bacteria. Specifically, the review is discussing the mechanism through which bacterial polysaccharides exert anti-inflammatory, antioxidant, anti-cancer, and anti-microbial properties. In addition, they are holding promising application in the 3D printing. The review is also discussing a perspective about the metagenome-based screening of polysaccharides, their integration with other cutting-edge tools, and synthetic microbiome base intervention of polysaccharides as a strategy for prebiotic intervention. This review has collected interesting information about the bacterial polysaccharides from Google Scholar, PubMed, Scopus, and Web of Science databases. Up to our knowledge, this is the first of its kind review article that is summarizing therapeutic, prebiotics, and commercial application of bacterial polysaccharides.

“…Polysaccharides, very important bioactive macromolecules, have long been used as additives in healthy foods due to their various biological effects and in emulsions to improve texture, water retention, and stabilization ( 10 ). These molecules are proven to have antioxidative, hypolipidemic, and anti-tumor activities ( 11 – 13 ). The complex structures of polysaccharides, including the variety of monosaccharide components and the various linkage and configuration patterns, give them their diverse functional properties ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization of Polysaccharides in Waste Liquor Produced by Wet Decortication of Sesame Seeds

Zhang

et al. 2022

The wet decortication of sesame seeds produces wastewater containing diverse minerals and organic pollutants that could be valuable resources for the food industry. This investigation aimed to reclaim, purify, and characterize the polysaccharides contained in the waste liquor from the sesame decortication industry. The purified polysaccharide fractions were characterized using monosaccharide analysis, GPC (high-performance gel permeation chromatography), FT-IR (Fourier-transform infrared) spectroscopy, methylation analysis, 1D and 2D Nucleai Magnetic Resonance (NMR) analysis, and thermal analysis. Four fractions were found (SSP-1,-2,-3, -4), of which SSP-2 was proportionately the largest and most interesting. The backbone of SSP-2 is mainly composed of (1→2,4)-β-D-Xylp residues with side chains connected to the O-4 position, with many T-β-D-Galp and (1→5)-α-L-Araf residues, and fewer (1→4)-α-D-Glcp, (1→2)-α-L-Rhap, T-α-L-Araf, and (1→2)-β-D-GlcpA residues. An efficient method for removing the polysaccharides would simplify wastewater treatment while finding a use for them would benefit the sesame, food, and pharmaceutical industries.