Polysaccharides and proteins-based nanogenerator for energy harvesting and sensing: A review

Cao, Lilong; Qiu, Xia; Qin, Jiao; Zhao, Pin-Yi; Li, Junjie; Wei, Yuping

doi:10.1016/j.ijbiomac.2021.01.109

Cited by 26 publications

(16 citation statements)

References 142 publications

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“…TENGs should have the characteristics of small size, strong tolerance to complex environments, and long‐term operation. [ 16 ] In terms of material optimization, high triboelectric performance, long‐term existence in vivo and environment‐friendly materials should be selected. The cytotoxicity of the incorporated materials should be studied and tested regularly.…”

Section: Challenges and Future Prospect For Cell Stimulation With Tengsmentioning

confidence: 99%

Recent advances of cellular stimulation with triboelectric nanogenerators

Zhou

et al. 2023

Exploration

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Triboelectric nanogenerators (TENGs) are new energy collection devices that have the characteristics of high efficiency, low cost, miniaturization capability, and convenient manufacture. TENGs mainly utilize the triboelectric effect to obtain mechanical energy from organisms or the environment, and this mechanical energy is then converted into and output as electrical energy. Bioelectricity is a phenomenon that widely exists in various cellular processes, including cell proliferation, senescence, apoptosis, as well as adjacent cells’ communication and coordination. Therefore, based on these features, TENGs can be applied in organisms to collect energy and output electrical stimulation to act on cells, changing their activities and thereby playing a role in regulating cellular function and interfering with cellular fate, which can further develop into new methods of health care and disease intervention. In this review, we first introduce the working principle of TENGs and their working modes, and then summarize the current research status of cellular function regulation and fate determination stimulated by TENGs, and also analyze their application prospects for changing various processes of cell activity. Finally, we discuss the opportunities and challenges of TENGs in the fields of life science and biomedical engineering, and propose a variety of possibilities for their potential development direction.

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Section: Challenges and Future Prospect For Cell Stimulation With Tengsmentioning

confidence: 99%

Recent advances of cellular stimulation with triboelectric nanogenerators

Zhou

et al. 2023

Exploration

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“…This group of materials are probably the most broadly studied piezoelectric biomaterials. There are also number of review articles focusing on the piezoelectric property of polysaccharides, particularly cellulose nanocrystals (CNC). − Therefore, here we do not intend to reiterate all the details of recent progresses of piezoelectric CNC-related materials. Instead, we focus on a few key aspects of polysaccharides’ structure, alignment, and properties in comparison to other materials discussed above to bring up a full spectrum of piezoelectric biomaterials for readers to reference.…”

Section: Polysaccharidesmentioning

confidence: 99%

“…Therefore, most reported cellulose-based NGs were built on composites with other piezoelectric materials or through other mechanisms, such as the triboelectric effect. As this application strategy has been covered extensively in recent reviews, ,,,, here we will not go into further details on this directly. However, we want to point out that the piezoelectric effect is a bulk/volume-related property and is more significant in charge generation compared to the triboelectric effect.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Natural Piezoelectric Biomaterials: A Biocompatible and Sustainable Building Block for Biomedical Devices

2022

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The piezoelectric effect has been widely observed in biological systems, and its applications in biomedical field are emerging. Recent advances of wearable and implantable biomedical devices bring promise as well as requirements for the piezoelectric materials building blocks. Owing to their biocompatibility, biosafety, and environmental sustainability, natural piezoelectric biomaterials are known as a promising candidate in this emerging field, with a potential to replace conventional piezoelectric ceramics and synthetic polymers. Herein, we provide a thorough review of recent progresses of research on five major types of piezoelectric biomaterials including amino acids, peptides, proteins, viruses, and polysaccharides. Our discussion focuses on their structure-and phaserelated piezoelectric properties and fabrication strategies to achieve desired piezoelectric phases. We compare and analyze their piezoelectric performance and further introduce and comment on the approaches to improve their piezoelectric property. Representative biomedical applications of this group of functional biomaterials including energy harvesting, sensing, and tissue engineering are also discussed. We envision that molecular-level understanding of the piezoelectric effect, piezoelectric response improvement, and large-scale manufacturing are three main challenges as well as research and development opportunities in this promising interdisciplinary field.

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“…synthetic polymers (polycaprolactone [PCL], poly(lactic-co-glycolic acid (PLGA), polylactic acid (PLA), polyvinyl alcohol (PVA), etc.). [104][105][106] Table 1 summarizes the various types of bioabsorbable and biodegradable TENGs (BD-TENGs) fabricated for powering various medical and non-medical electronic devices. As an example, Liang et al [107] reported a recyclable and green TENG fabricated by PVA and sodium alginate friction layers with nanostructured patterns, and Li and Al as the electrodes (Figure 2A).…”

Section: Triboelectric Nanogenerators For On-body Electricity Generationmentioning

confidence: 99%

Advances in Triboelectric Nanogenerators for Self‐Powered Regenerative Medicine

Parandeh

Etemadi

Kharaziha

et al. 2021

Adv Funct Materials

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Over the last decade, in pursuit to provide suitable alternatives for power supplies of medical devices in regenerative medicine, extensive research on nanogenerators has been developed. Such devices can overcome current commercial battery challenges, including intense heat-on-body complications due to the electrical current during therapeutic usage, leading to protein denaturation, cell structure destruction, and even cell necrosis. In addition, these traditional batteries contain a bulky and heavy structure that prevents them from providing sustainable on body biomedical therapeutic intervention. Furthermore, advantages such as wide-range biocompatible and biodegradable materials, lightweight, and sufficient stretchability for device construction can minimize the side effects of implantable devices, including inflammation or toxicity, as well as eliminate secondary surgery to replace or remove batteries. Triboelectric nanogenerators (TENGs) are associated with harvesting mechanical energy in various forms, among which human body motions can serve as a renewable power source for healthcare systems. This review is written to emphasize the importance of TENG's applications in regenerative medicine and modulation purposes, particularly for the nervous system. Some crucial parameters for implantable consideration are discussed. In the concluding remarks, features for clinical utilization including output efficiency, encapsulation, stability, and miniaturization are suggested as challenges and prospects.

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Polysaccharides and proteins-based nanogenerator for energy harvesting and sensing: A review

Cited by 26 publications

References 142 publications

Recent advances of cellular stimulation with triboelectric nanogenerators

Recent advances of cellular stimulation with triboelectric nanogenerators

Natural Piezoelectric Biomaterials: A Biocompatible and Sustainable Building Block for Biomedical Devices

Advances in Triboelectric Nanogenerators for Self‐Powered Regenerative Medicine

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