Polysaccharide hydrogels for protein drug delivery

Chen, Jun; Jo, Seong Mu; Park, Kinam

doi:10.1016/0144-8617(95)00080-1

Cited by 133 publications

(75 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, it is reported that polysaccharide can enhance the absorption of protein drugs. 2 Chitin and its deacetylated form, chitosan, have received much attention as a material for biomedical and drug delivery applications over the last two decades for their appealing properties. 3,4 Chitosan has good biocompatibility and can be degraded by certain human enzymes.…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte complex beads composed of water‐soluble chitosan/alginate: Characterization and their protein release behavior

Shi

Sun

et al. 2006

J of Applied Polymer Sci

View full text Add to dashboard Cite

Polyelectrolyte complex (PEC) beads were prepared from water-soluble chitosan (WSC) and alginate complex solution with different ratios by dropping method, and all procedures used were performed in aqueous medium at neutral environment. The structure and morphology of the beads were characterized by IR spectroscopy and scanning electron microscopy (SEM). IR spectroscopy confirmed the electrostatic interactions between amino groups of WSC and carboxyl groups of alginate. SEM showed internal section of the PEC bead, which had porous structure compared with compact structure of alginate beads. The swelling behavior, encapsulation efficiency, and release behavior of bovine serum albumin (BSA) from the beads at different pHs were investigated. PEC beads demonstrated different responses to pH from alginate beads. The ratio of WSC to alginate influenced the encapsulation and release of BSA. At pH 1.2, small amount (Ͻ 15%) of BSA was released from the PEC beads except AC12. However, at pH 7.4, a large amount (Ͼ 80%) of BSA was released from AL in the first 3 h due to the rapid disintegration of the beads, whereas BSA release was retarded from complex beads due to the forming of PEC. The results suggested that the WSC/alginate beads could be a suitable polymeric carrier for sitespecific protein drug delivery in the intestine.

show abstract

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte complex beads composed of water‐soluble chitosan/alginate: Characterization and their protein release behavior

Shi

Sun

et al. 2006

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…On the other hand, hydrogels of natural polymers, especially polysaccharides, have recently found widespread applications because of their unique advantages. Polysaccharides are, in general, non-toxic, biocompatible, biodegradable and abundant [10,11]. The hydrogels based on saponified starch graft copolymer are widely used in consumer products such as adult incontinence pads, diapers and sanitary products [12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Saponification of Poly (AN)-Starch Composites and Properties of their Hydrogels

Hashem¹,

Afifi²,

El‐Alfy³

et al. 2005

American J. of Applied Sciences

View full text Add to dashboard Cite

Hydrogels based on saponified products of poly (acrylonitrile, AN)-starch composites were prepared, characterized and their water abosrbency properties examined. The term composite refered to the resultant products of polymerizatin of AN with starch in presence of ceric ammonium nitrate (CAN) as initiator, that is the composite consists of poly(AN)-starch graft copolymer, homopoly(AN) , oxidized starch and unreacted starch. Thus AN monomer was polymerized with gelatinized starch using the ceric ion method. Gelatinization of starch prior to polymerization was affected by heating certain weight of starch in certain volume of distilled water at different temperrature (65, 75 and 85°C). Polymerization was carried out under a variety of coditions. Saponification of poly (AN)-starch composites was performed in sodium hydroxide to yield the hydrogels. The water absorbency properties of these hydrogels were found to rely on variables affecting the magnitudes of both polymerization and saponification. Among these variables mention was made of the starch/liquor ratio, cocentration of ceric ammonium nitrate (CAN), monomer/starch molar ratio, duration of grafting and gelatinization temperature as well as saponification time. Hydrogels display their maximum water absorbency when granular starch was firstly gelatinized at 85°C for 30 min and secondly subjected to polymerization with AN using AN/starch molar ratio of 4.8 and CAN concentration of 10 mmol/L liquor ratio of 12.5 and thirdly sample of the so obtained poly (AN)-starch composite was saponified in sodium hydroxide (0.7 N) at 95°C for 180 min. The saponified product was then precipitated in excess methanol, dried and finally converted into powder. The product (hydrogel) in the powder form exhibited maximum water absorbency of 920 g water per gram hydrogel and 38 mL synthetic urine per gram hydrogel.

show abstract

“…In the past decade polysaccharides, one of the natural polymers, have been shown to play an important role in the biomedical, controlled release and biochemical fields with several industrial applications (Chen, Jo, & Park, 1995;Liu, Jiao, Wang, Zhou, & Zhang, 2008). Konjac glucomannan (KGM), a high molecular weight and water soluble natural polysaccharide isolated from the tubers of the widespread plant Amorphophallus konjac in China and Japan, is composed of b-(1 ?…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer

Xia

Meng

et al. 2010

Carbohydrate Polymers

View full text Add to dashboard Cite

Polysaccharide hydrogels for protein drug delivery

Cited by 133 publications

References 51 publications

Polyelectrolyte complex beads composed of water‐soluble chitosan/alginate: Characterization and their protein release behavior

Polyelectrolyte complex beads composed of water‐soluble chitosan/alginate: Characterization and their protein release behavior

Synthesis, Characterization and Saponification of Poly (AN)-Starch Composites and Properties of their Hydrogels

Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer

Contact Info

Product

Resources

About