Polysaccharide from <i>Spirulina platensis</i> Evokes Antitumor Activity in Gastric Cancer Cells <i>via</i> Modulation of Galectin-3 and Exhibited Cyto/DNA Protection: Structure–Function Study

Uppin, Vinayak; Dharmesh, Shylaja M.; Ravi, Saranya

doi:10.1021/acs.jafc.2c00176

Cited by 16 publications

(7 citation statements)

References 57 publications

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“…Moreover, PS production occurs primarily during the stationary phase of the microalgae culture [116]. Chlorella sp., Arthrospira platensis, Porphyridium, D. salina, and Euglena gracilis are the most extensively investigated eukaryotic microalgae and cyanobacteria used for the production and extraction of PS [119][120][121][122][123]. Some such species can generate substantial amounts of EPS during algal cultivation owing to typical physiological processes, whilst others must be stressed in order to synthesize these compounds [114].…”

Section: Polysaccharidesmentioning

confidence: 99%

Advances in Genetic Engineering in Improving Photosynthesis and Microalgal Productivity

Wang

Chen

et al. 2023

IJMS

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Even though sunlight energy far outweighs the energy required by human activities, its utilization is a key goal in the field of renewable energies. Microalgae have emerged as a promising new and sustainable feedstock for meeting rising food and feed demand. Because traditional methods of microalgal improvement are likely to have reached their limits, genetic engineering is expected to allow for further increases in the photosynthesis and productivity of microalgae. Understanding the mechanisms that control photosynthesis will enable researchers to identify targets for genetic engineering and, in the end, increase biomass yield, offsetting the costs of cultivation systems and downstream biomass processing. This review describes the molecular events that happen during photosynthesis and microalgal productivity through genetic engineering and discusses future strategies and the limitations of genetic engineering in microalgal productivity. We highlight the major achievements in manipulating the fundamental mechanisms of microalgal photosynthesis and biomass production, as well as promising approaches for making significant contributions to upcoming microalgal-based biotechnology.

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Section: Polysaccharidesmentioning

confidence: 99%

Advances in Genetic Engineering in Improving Photosynthesis and Microalgal Productivity

Wang

Chen

et al. 2023

IJMS

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“…After treatment with 40 μg/mL SP for 48 h, the activity of human gastric cancer cells (AGS) was inhibited by 50%. 41 At present, there are few studies on the inhibition of tumor proliferation by galactose. It is believed that galactose can bind to galectin-3, thereby blocking metastasis and angiogenesis in cancers.…”

Section: ■ Polysaccharides and Cancersmentioning

confidence: 99%

“…Spirulina polysaccharides (SPs) were mainly composed of galactose (42%). After treatment with 40 μg/mL SP for 48 h, the activity of human gastric cancer cells (AGS) was inhibited by 50% . At present, there are few studies on the inhibition of tumor proliferation by galactose.…”

Section: Polysaccharides and Cancersmentioning

confidence: 99%

Targeting mTOR Signaling by Dietary Polysaccharides in Cancer Prevention: Advances and Challenges

Guo

et al. 2022

J. Agric. Food Chem.

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Cancer is the most serious problem for public health. Traditional treatments often come with unavoidable side effects. Therefore, the therapeutic effects of natural products with wide sources and low toxicity are attracting more and more attention. Polysaccharides have been shown to have cancer-fighting potential, but the molecular mechanisms remain unclear. The mammalian target of rapamycin (mTOR) pathway has become an attractive target of antitumor therapy research in recent years. The regulation of mTOR pathway not only affects cell proliferation and growth but also has an important effect in tumor metabolism. Recent studies indicate that dietary polysaccharides play a vital role in cancer prevention and treatment by regulating mTOR pathway. Here, the progress in targeting mTOR signaling by dietary polysaccharides in cancer prevention and their molecular mechanisms are systemically summarized. It will promote the understanding of the anticancer effects of polysaccharides and provide reference to investigators of this cutting edge field.

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“…Meanwhile, published articles on the effects of AdSP on cell behavior are mainly focused on the inhibition of tumor cell proliferation, anti-angiogenesis, enhancement of hematopoietic stem cells, etc. [ 12 , 13 , 14 ]. Only one study focuses on the effects of AdSP on the behavior of neural stem cells [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Cell Behavior by the Polysaccharide Extract of Arthrospira and Potential Biomedical Applications

Hsu

2023

Molecules

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Arthrospira is one of the most studied cyanobacteria and has been reported with practical applications. Among the substances derived from Arthrospira, polysaccharides have received relatively less attention than phycocyanins, though they have more abundant structural variations and specific properties. Herein, a new Arthrospira-derived sulfated polysaccharide was explored for its potential bioactive functions. The ability of this sulfated polysaccharide to promote the behavior of neural stem cells (NSCs) in three-dimensional hydrogel was examined for the first time. NSCs encapsulated in the sulfated polysaccharide-containing hydrogel showed better proliferation than the control hydrogel as well as a unique cell clustering behavior, i.e., formation of multicellular spherical clusters (40–60 μm). The sulfated polysaccharide, in an appropriate range of concentration (5 mg/mL), also maintained the stemness of NSCs in hydrogel and facilitated their differentiation. In addition, the potentials of the new sulfated polysaccharide as a coating material and as a component for drug carrier were verified. The sulfated polysaccharide-modified substrate exhibited superhydrophilicity (contact angle ~9) and promoted cell adhesion to the substrate. Composite nanoparticles composed of the sulfated polysaccharide and other differently charged polysaccharides were produced with an average diameter of ~240 nm and estimated drug loading of ~18%. The new Arthrospira-derived sulfated polysaccharide is a promising candidate for cell culture, surface-modification, and drug-delivery applications in the biomedical field.

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Polysaccharide from Spirulina platensis Evokes Antitumor Activity in Gastric Cancer Cells via Modulation of Galectin-3 and Exhibited Cyto/DNA Protection: Structure–Function Study

Cited by 16 publications

References 57 publications

Advances in Genetic Engineering in Improving Photosynthesis and Microalgal Productivity

Advances in Genetic Engineering in Improving Photosynthesis and Microalgal Productivity

Targeting mTOR Signaling by Dietary Polysaccharides in Cancer Prevention: Advances and Challenges

Enhancement of Cell Behavior by the Polysaccharide Extract of Arthrospira and Potential Biomedical Applications

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