Polysaccharide based superabsorbent hydrogel from Mimosa pudica: swelling–deswelling and drug release

Muhammad, Gulzar; Hussain, Muhammad Ajaz; Ashraf, Muhammad; Haseeb, Muhammad Tahir; Hussain, Syed Zajif; Hussain, Irshad

doi:10.1039/c5ra23088h

Cited by 36 publications

(20 citation statements)

References 36 publications

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“…BSH was isolated from the seeds of O. basilicum as reported elsewhere with some modification [3,4,10]. Briefly, seeds of O. basilicum (50 g) were soaked in deionized water (1000 mL) for 4 h before warming at 40 ∘ C for 45 min.…”

Section: Isolation Of Bshmentioning

confidence: 99%

“…They have got great attraction of researchers and technologists due to their extensive biomedical applications [1,2]. Such hydrogels have interconnected microscopic pores and elasticity, possessing hydrophilic functional groups (hydroxyl, carboxylic acid, amide, and sulphate) which enhance their water holding and swelling capacity [3,4]. Hydrogels have also reversible volume phase transitions depending on stimuli factors such as temperature, ionic strength, pH, solvent composition, and electric field [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Minor components are protein, minerals, and fat [22]. The polysaccharides extracted from OBS by cold water extraction and alcohol precipitation consist of two major fractions, i.e., an acid-stable core glucomannan and a (1)(2)(3)(4) linked xylan having acidic side chains. Glucomannan constitutes a major fraction (43%) having glucose to mannose ratio of 10:2, minor fraction of xylan (24%), and a smaller portion of glucan (2.31%) [23].…”

Section: Introductionmentioning

confidence: 99%

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Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Lodhi

Hussain

Sher

et al. 2019

Advances in Polymer Technology

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This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water. Highly reversible on-off switching (swellingdeswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline. Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of BSH having average pore size of 1.92 ± 3.83 m noted after swelling and lyophilization. BSH containing tablet formulations showed a sustained release pattern of diclofenac sodium (DS) which is dependent on the concentration of BSH. When comparing with commercially available formulation of DS, even better sustained release behavior of DS was observed in BSH-based formulation. Super case-II transport mechanism is followed by the DS release from BSH matrix tablet. Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic. Recently, polysaccharide-based hydrogels have gained a lot of interest in drug delivery system due to their extraordinary swelling indices, stimuli responsive properties, biodegradability, biocompatibility, and nontoxicity [9][10][11][12][13].Ocimum basilicum L., (Syn: sweet basil in English, Babui tulsi in Hindi and Marathi, Rihan in Arabic, Niasabo in Gujrati, Jangli tulsi in Urdu, Tohrakhurasani in Persian, and Okimon in Unani) is a popular culinary and ornamental herb

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Section: Isolation Of Bshmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Lodhi

Hussain

Sher

et al. 2019

Advances in Polymer Technology

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“…Among these, polysaccharides based polymeric biomaterials have drawn appreciable attention of the biomedical scientists due to their biocompatibility (Dang, Leong, 2006), biodegradability (Jain, Gupta, Jain, 2007), bioavailability (Mizrahy, Peer, 2012), ease and versatility in drug designing and development (Zhang, Wardwell, Bader, 2013;Hussain et al, 2011;Hussain et al, 2009). These properties also make such naturally occurring polysaccharides an integral part of many drug delivery systems Xu et al, 2015;Muhammad et al, 2016;Ashraf et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity study of a polysaccharide based hydrogel from linseed for potential use in drug delivery system

Haseeb

Bashir

Hussain

et al. 2018

Braz. J. Pharm. Sci.

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Linseed hydrogel (LSH) was evaluated by acute toxicity for its potential application in oral drug delivery design. White albino mice and rabbits were divided in four groups (I-IV) and different doses of LSH (1, 2 and 5 g/kg body weight) were given except to the control group (I) that was left untreated. Rabbits were monitored for eye irritation, acute dermal toxicity and primary dermal irritation, whereas, body weight, food and water consumption, hematology and clinical biochemistry, gross necropsy and histopathology of vital organs were scrutinized in mice. LSH was considered safe after eye irritation test as no adverse signs or symptoms were seen in the eye. In dermal toxicity and irritation study, skin of treated rabbits was found normal in color without any edema or erythema. After oral administration, there was no sign of any abnormalities in treated group animals (II-IV). The hematology and clinical biochemistry of treated group animals was comparable with the control group. Histopathology of vital organs has not shown any lesion or abnormalities. In the light of these outcomes, it can be concluded that LSH is not a hazardous biomaterial and could be incorporated as an excipient in oral and dermal preparations.

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“…Hydrogel pearls have been considered for a potential use in drug delivery. Muhammad et al 15 evaluated a polysaccharide, glucuronoxylan, isolated from the Mimosa púdica seed. They studied its behavior, its swelling and de-swelling and the release of the drug diclofenac.…”

Section: Introductionmentioning

confidence: 99%

THE USE OF POLYSACCHARIDES EXTRACTED FROM SEED OF Persea americana var. Hass ON THE SYNTHESIS OF ACRYLIC HYDROGELS

Lara-Valencia¹,

Dávila-Soto²,

Moscoso-Sánchez³

et al. 2017

Quim. Nova

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This paper reports the use of polysaccharides extracted from seed of Persea americana var. Hass in the synthesis of acrylic hydrogels. The effects of the chemical composition (acrylamide/acrylic acid), the concentration of crosslinking agent (glycerol diacrylate) and the type of initiation (redox, photoinitiation) of the hydrogels were evaluated with and without polysaccharides. Xerogels were characterized by FTIR spectroscopy, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM), while for the swollen hydrogels the swelling kinetic and mechanical properties were evaluated. The kinetic parameters were obtained using the second order equation proposed by Schott, where it is reported that by increasing the concentration of the crosslinking agent, the degree of swelling is reduced because of the greater structural level. The increase of the amount of acrylamide and the amount of polysaccharides causes also a decrease in the swelling degree. The type of initiation also affected the hydrogels swelling kinetic, the photoinitiated hydrogels were the ones that captured less water. Moreover, the increasing of the glass transition temperature and the compression modulus with the crosslinking agent concentration and molar ratio AAm/AAc are observed for hydrogels with and without polysaccharides. The results demonstrate a successful incorporation of polysaccharides into the polymeric network.

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Polysaccharide based superabsorbent hydrogel from Mimosa pudica: swelling–deswelling and drug release

Abstract: Polysaccharide based stimuli responsive, superporous and superabsorbent hydrogel for sustained drug release.

Cited by 36 publications

References 36 publications

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Acute toxicity study of a polysaccharide based hydrogel from linseed for potential use in drug delivery system

THE USE OF POLYSACCHARIDES EXTRACTED FROM SEED OF Persea americana var. Hass ON THE SYNTHESIS OF ACRYLIC HYDROGELS

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