Polysaccharide and poly(methacrylic acid) based biodegradable elastomeric biocompatible semi-IPN hydrogel for controlled drug delivery

Ganguly, Sayan; Maity, Pintu; Mondal, Subhadip; Das, Poushali; Bhawal, Poushali; Dhara, Santanu

doi:10.1016/j.msec.2018.06.034

Cited by 80 publications

(45 citation statements)

References 73 publications

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“…The thermal analysis of chopped short fibre composites revealed that the main mass loss process ends at around 255.99-312.15 • C. The decomposition of cellulose and hemicelluloses started around 255 • C. The decomposition was fast above this temperature and completed around 463.26 • C. A total weight loss of the composites was observed in the decomposition of sisal polyester composites. A similar trend was observed with our earlier work on sisal textile composites and research studies on nanoclay-filled polymer composites by Ganguly et al [38,42].…”

Section: 2csupporting

confidence: 91%

Synthesis and characterization of short sisal fibre polyester composites

et al. 2019

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Natural fibres have the potential to replace synthetic fibres for making polymer composites because of their good engineering properties. Sisal fibres obtained from the leaves of the sisal plant exhibit high strength among various other natural fibres, but have not been yet fully explored. Nevertheless, the impact of sisal fibre in polymer composites depends on sisal fibre extraction process, characteristic of fibre, fibre binder ratios, synthesizing technique, etc. In the present study, a detailed experimental protocol was conducted for sisal cultivation, fibre extraction, processing and development of composite boards/panels and assessed the impact of incorporation of chopped strand sisal fibre mat on the mechanical behaviour of polyester composites. The results revealed that the diameter of sisal fibre harvested after 5 years of its cultivation varied from 275 to 475 µm with a tensile strength of 121-337 MPa; tensile modulus of 2.59-10.47 GPa; elongation at break varied from 3.37 to 10.86%. It is imperative to note that the mechanical properties of sisal composites significantly improved with the incorporation of chopped strand sisal fibre mat (preform). The tensile, flexural and impact strengths of composites developed using chopped short sisal fibre mat (preform) were 45.87 ± 3.2, 102.29 ± 9, 33,954 ± 5288 J m −2 , respectively. The findings of the study revealed the effectiveness of sisal fibre as reinforcing materials in polyester composites for use in building construction products and automotive applications.

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Section: 2csupporting

confidence: 91%

Synthesis and characterization of short sisal fibre polyester composites

et al. 2019

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“…The vial-inversion test and rheological study indicate gelation of CP hydrogel system at 32.2 °C. The system shows Newtonian fluid-like consistency below 32 °C, which turns in to gel with radical increase in storage modulus above critical gelation temperature 31 . The point at temperature 32.2 °C may be defined as the critical gelation temperature ( T gel ).…”

Section: Discussionmentioning

confidence: 99%

“…Cytotoxicity and cell proliferation assay were evaluated by Rhodamin-DAPI and Live-dead assay, as previously described 31 . The assay of the cells on the samples and control were examined after 1, 3, and 5 days studies.…”

Section: Methodsmentioning

confidence: 99%

Isolation and mass spectrometry based hydroxyproline mapping of type II collagen derived from Capra hircus ear cartilage

et al. 2019

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Collagen II (COLII), the most abundant protein in vertebrates, helps maintain the structural and functional integrity of cartilage. Delivery of COLII from animal sources could improve cartilage regeneration therapies. Here we show that COLII can be purified from the Capra ear cartilage, a commonly available bio-waste product, with a high yield. MALDI-MS/MS analysis evidenced post-translational modifications of the signature triplet, Glycine-Proline-Hydroxyproline (G-P-Hyp), in alpha chain of isolated COLII (COLIIA1). Additionally, thirty-two peptides containing 59 Hyp residues and a few G-X-Y triplets with positional alterations of Hyp in COLIIA1 are also identified. Furthermore, we show that an injectable hydrogel formulation containing the isolated COLII facilitates chondrogenic differentiation towards cartilage regeneration. These findings show that COLII can be isolated from Capra ear cartilage and that positional alteration of Hyp in its structural motif, as detected by newly developed mass spectrometric method, might be an early marker of cartilage disorder.

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“…[3]. Also, for the same application, grafted polymethacrylic acid onto sodium alginate and the prepared hydrogel possess biodegradability, noncytotoxicity toughness, rubberlike elasticity, and suitability for responsive controlled release vector [4].…”

Section: Introductionmentioning

confidence: 96%

Acrylate/Nanofibrillated Cellulose Nanocomposites and Their Use for Paper Coating

Hassan

Fadel

Hassan

2018

Journal of Nanomaterials

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Nanofibrillated cellulose (NFC) isolated from TEMPO-oxidized rice straw was used to improve thermal and tensile strength properties of acrylate polymer films. Acrylate/NFC mixture containing 15% NFC was used for paper coating, and properties of paper sheets including tensile strength, water absorption, and microscopic structure were investigated. The results showed that the presence of NFC in the acrylate matrix significantly improved tensile strength properties and thermomechanical properties of the acrylate polymer and caused moderate increase in its moisture sorption. The presence of NFC in acrylate emulsion caused significant increase in its viscosity. Paper sheets coated with different thin layers (from 0.2 to 6 microns) of acrylate/NFC showed improvement in tensile strength and decrease of water absorption.

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Polysaccharide and poly(methacrylic acid) based biodegradable elastomeric biocompatible semi-IPN hydrogel for controlled drug delivery

Cited by 80 publications

References 73 publications

Synthesis and characterization of short sisal fibre polyester composites

Synthesis and characterization of short sisal fibre polyester composites

Isolation and mass spectrometry based hydroxyproline mapping of type II collagen derived from Capra hircus ear cartilage

Acrylate/Nanofibrillated Cellulose Nanocomposites and Their Use for Paper Coating

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