Polyradiculoneuritis Secondary to Immunization With Tetanus and Diphtheria Toxoids

Holliday, Patti L.; Bauer, Robert O.

doi:10.1001/archneur.1983.04050010076025

Cited by 31 publications

(5 citation statements)

References 6 publications

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“…Furthermore, hyper‐immunization of women commonly results in muscle soreness ( Collier et al . 1979 ) and can also in rare instances lead to polyneuropathy ( Holliday & Bauer 1983) with an estimated incidence of 0.4 cases per million doses of TT ( Quast et al . 1979 ).…”

Section: Discussionmentioning

confidence: 99%

“…A previous study has speculated that multiple TT booster doses may enhance serum TT antibody levels that could lead to an ineffective immune response (Maselle et al 1991). Furthermore, hyper-immunization of women commonly results in muscle soreness (Collier et al 1979) and can also in rare instances lead to polyneuropathy (Holliday & Bauer 1983) with an estimated incidence of 0.4 cases per million doses of TT (Quast et al 1979). These side-effects might have negative impact on compliance to vaccination and consequently on the immunization programme.…”

Section: Discussionmentioning

confidence: 99%

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Antibodies to tetanus toxoid in women of childbearing age in Dar es Salaam and Bagamoyo, Tanzania

Aboud

Matre

Lyamuya

et al. 2001

Tropical Med Int Health

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SummaryOur aim was to determine tetanus immunity in women of childbearing age (15±44 years) with histories and/or documentation of having been vaccinated with Tetanus Toxoid (TT) under the Expanded Programme on Immunization in Dar es Salaam and Bagamoyo, Tanzania. Using an ELISA technique, serum levels of TT antibody, antibody avidity and distribution of TT IgG subclass antibodies were determined in 207 apparently healthy women. A TT antibody level of 0.1 IU/ml was considered protective. 99% and 100% of women in Dar es Salaam and Bagamoyo, respectively, had a TT antibody level ³0.1 IU/ml. Anti-toxin binding avidity was found to be high in most of the women. In addition to TT IgG3 subclass antibody, TT IgG1 subclass antibody was the most dominant subclass type. A substantial number of women also had TT IgG2 and TT IgG4 subclass antibody responses. A better recording system on TT immunization is recommended to avoid hyper-immunization of women and to optimize the cost-effectiveness of the immunization programme.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibodies to tetanus toxoid in women of childbearing age in Dar es Salaam and Bagamoyo, Tanzania

Aboud

Matre

Lyamuya

et al. 2001

Tropical Med Int Health

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“…The period between vaccination and first symptoms of GBS, range from as short as 3-5 days, to 6-10 weeks, and up to a few months and even years ( Table 2). The temporal association and lack of infections in those individual cases can indicate a causal association [19][20][21][22][23]. However, in the epidemiological studies cited, no significant causal association was found.…”

Section: Vaccinations and Gbsmentioning

confidence: 98%

Guillain–Barré Syndrome—A Classical Autoimmune Disease Triggered by Infection or Vaccination

Israeli

Agmon‐Levin

Blank

et al. 2010

Clinic Rev Allerg Immunol

101

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Guillain-Barré syndrome (GBS) is a rare autoimmune disorder, the incidence of which is estimated to be 0.6-4/100,000 person/year worldwide. Often, GBS occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal microbial infection. The disorder is sub-acute developing over the course of hours or days up to 3 to 4 weeks. About a third of all cases of Guillain-Barré syndrome are preceded by Campylobacter jejuni infection. C. jejuni strains isolated from GBS patients have a lipooligosaccharide (LOS) with a GM1-like structure. Molecular mimicry between LOS and the peripheral nerves as a cause of GBS was demonstrated in animal models of human GBS. Following the "swine flu" virus vaccine program in the USA in 1976, an increase in incidence of GBS was observed and the calculated relative risk was 6.2. Later studies have found that influenza vaccines contained structures that can induce anti-GM1 (ganglioside) antibodies after inoculation into mice. More recent information has suggested that the occurrence of GBS after currently used influenza and other vaccines is rare. GBS involves genetic and environmental factors, may be triggered by infections or vaccinations, and predisposition can be predicted by analyzing some of these factors.

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“…Currently available rabies vaccines, prepared in human diploid cells or fetal rhesus lung cells, lack the high risk (approximately 1 in 5000) of neurologic complications (encephalomyelitis and peripheral neuropathy) observed with older vaccines derived from neural tissues.l3' Current vaccines frequently produce mild, self-limited systemic reactions consisting of headache, myalgias, and dizziness. Infrequently, Guillain-Barre syndrome has been reported within 12 weeks after immunization with the newer vaccines.33…”

Section: Rabiesmentioning

confidence: 99%

Topical Review: Neurologic Complications of Immunization

Bale

2004

J Child Neurol

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In the United States and many other developed countries, active immunization of children has virtually eliminated poliomyelitis, measles, rubella, tetanus, and other diseases, such as disease due to Haemophilus influenzae type b. Individual vaccines can produce systemic or neurologic reactions ranging from minor events, such as pain and erythema at the injection site, to major complications, such as seizures, shock, encephalopathy, or death. Immunization programs have also generated considerable controversy, as witnessed by recent concerns regarding the relationship between vaccines or their constituents and autism or multiple sclerosis. This review summarizes current information regarding vaccines, the diseases that they prevent, and the potential relationships between vaccines and neurologic disease.

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Polyradiculoneuritis Secondary to Immunization With Tetanus and Diphtheria Toxoids

Cited by 31 publications

References 6 publications

Antibodies to tetanus toxoid in women of childbearing age in Dar es Salaam and Bagamoyo, Tanzania

Antibodies to tetanus toxoid in women of childbearing age in Dar es Salaam and Bagamoyo, Tanzania

Guillain–Barré Syndrome—A Classical Autoimmune Disease Triggered by Infection or Vaccination

Topical Review: Neurologic Complications of Immunization

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