Polypoidal Choroidal Vasculopathy in Association With Choroidal Nevus

Peiretti, Enrico; Pozzoni, María Carolina; Fossarello, Maurizio; Spaide, Richard F.

doi:10.1097/icb.0b013e318166bd70

Cited by 17 publications

(17 citation statements)

References 8 publications

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“…Positive immunohistochemical staining for VEGF in the RPE and the vascular endothelial cells suggests that the vascular components of this polypoidal vascular complex were not dilated choroidal vessels but a subretinal CNV 21. Furthermore, polypoidal changes within neovascular process have been reported in PCV, and in a range of conditions including nAMD, central serous chorioretinopathy, peripheral exudative haemorrhagic chorioretinopathy22 and choroidal nevi 23. All of these supported that polyps may only represent a structural variant of neovascular tissue rather than signifying a distinct pathogenic mechanism.…”

Section: Discussionmentioning

confidence: 94%

Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a retrospective case series

et al. 2018

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Background and objectiveTo demonstrate the coexistence of polypoidal choroidal vasculopathy (PCV) with type 2 neovascularisation (NV), we used multimodal imaging, including spectral-domain optical coherence tomography angiography (SD-OCTA), to identify both types of lesions in the same eye.Study designThis retrospective case series reviewed patients with PCV diagnosed with indocyanine green angiography (ICGA), fluorescein angiography (FA), SD-OCT and SD-OCTA.Results15 eyes of 14 patients were imaged and diagnosed with PCV by ICGA. ICGA identified polyps in all these eyes, while SD-OCTA imaging identified polypoidal lesions in only 11 (73%) of these eyes with PCV. Branching vascular networks (BVNs) were detected in 12 eyes (80%) by ICGA and SD-OCTA. Type 2 NV was detected in four eyes (27%) by FA and SD-OCTA. In these eyes, a combination of polyps, BVNs and type 2 NV were detected using FA, ICGA and SD-OCTA.ConclusionBVN and type 2 NV can coexist in the same PCV eye and communicate with each other. This suggests that polyps may represent a structural variant of neovascular tissue rather than a distinct pathogenic process in NV.

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Section: Discussionmentioning

confidence: 94%

Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a retrospective case series

et al. 2018

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“…In each of these groups, there is mounting evidence that the mechanisms that underlie aneurysm formation differ from those which promote neovascularization in AMD. In addition, it has been recognized that aneurysmal type 1 neovascular lesions can occur in contexts far removed from either AMD or typical PCV, examples being choroidal nevi, myopic staphylomata and dome‐shaped maculopathy …”

Section: Resultsmentioning

confidence: 99%

Understanding aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy): a lesson in the taxonomy of ‘expanded spectra’ – a review

Dansingani

Gal-Or

Sadda

et al. 2017

Clinical Exper Ophthalmology

150

115

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The term aneurysmal type 1 neovascularization is derived from terminology, which is established in the literature but has fallen out of use. We believe that aneurysmal type 1 neovascularization accurately describes the lesions which define the entity known as polypoidal choroidal vasculopathy (PCV). Over the last three decades, the clinical spectrum of PCV has expanded to recognize the occurrence of the aneurysmal (polypoidal) lesions in different contexts, resulting in a complex and unwieldy taxonomy based sometimes on circumstantial findings rather than mechanistic considerations. Advances in multimodal imaging provides increasingly convincing evidence that the lesions which define various forms of PCV are indeed vascular and arise from type 1 neovascular networks. The understanding of PCV as type 1 neovascularization with aneurysms renews focus on the question as to why some patients with type 1 neovascularization develop aneurysms while others do not. Conceptual themes and potential for further study are discussed.

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“…[20][21][22] First described by Yannuzzi et al 20 and by Kleiner et al 21 as posterior uveal bleeding syndrome, PCV is often idiopathic, 22 but it has also been associated with other diagnoses such as tilted disc syndrome, choroidal nevi, and sickle cell retinopathy. [23][24][25][26] The prevalence of PCV has been reported as being higher in African American and Asian people compared with the Caucasian population, 27 and seems therefore to have a predilection for pigmented individuals. 28 Differentiating PCV from occult CNV can be difficult using only on FA or ophthalmic examination, and ICGA is considered as the most sensitive tool to diagnose the presence of PCV.…”

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confidence: 97%

Choroidal Neovascularization in Caucasian Patients With Longstanding Central Serous Chorioretinopathy

Peiretti

Ferrara

Caminiti

et al. 2015

Retina

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Polypoidal Choroidal Vasculopathy in Association With Choroidal Nevus

Abstract: PCV-like vascular changes can be associated with choroidal nevus, and ICG can help delineate the nature of the neovascularization in patients with choroidal nevus.

Cited by 17 publications

References 8 publications

Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a retrospective case series

Type 2 choroidal neovascularisation in polypoidal choroidal vasculopathy: a retrospective case series

Understanding aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy): a lesson in the taxonomy of ‘expanded spectra’ – a review

Choroidal Neovascularization in Caucasian Patients With Longstanding Central Serous Chorioretinopathy

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