Choroidal Neovascularization in Caucasian Patients With Longstanding Central Serous Chorioretinopathy

Peiretti, Enrico; Ferrara, Daniela; Caminiti, Giulia; Mura, Marco; Hughes, John M.

doi:10.1097/iae.0000000000000529

Cited by 51 publications

(36 citation statements)

References 46 publications

(60 reference statements)

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“…Previous studies suggest that CNV may be more prevalent in patients over 50 years of age with chronic CSC [7,15]. In the present study, CNV occurrence was 40.38% (21/52) in patients over 50 years of age and 17.86% (10/56) in patients under 50 years of age, which was statistically significant.…”

Section: Discussionsupporting

confidence: 63%

Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy: OCT Angiography Findings and Risk Factors

Yeo

Kim

et al. 2020

Journal of Ophthalmology

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Purpose. To identify the clinical characteristics and risk factors for secondary choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC). Methods. In this retrospective study, we included a total of 108 eyes in 106 CSC patients. Group A was defined as patients initially diagnosed with CSC who developed secondary CNV, and group B was defined as patients who did not develop secondary CNV. Clinical and demographic characteristics, optical coherence tomography (OCT) findings at CSC diagnosis and OCT angiography (OCTA) at the time of secondary CNV diagnosis, were compared between the groups. Results. Thirty-one eyes had CNV (group A) and 77 eyes did not (group B). The mean age of group A was higher than that of group B (52.28 ± 6.87 vs. 46.78 ± 9.45 years; P<0.001). Although there was no difference in pigment epithelial detachment (PED) height, group A had larger PED width than group B at CSC diagnosis. The foveal and parafoveal choriocapillary flow densities were significantly lower in group A than group B (P=0.027 and P<0.001, respectively). Conclusion. We identified that older age, wider PED width at diagnosis, and recurrent episodes of CSC were independent risk factors for development of secondary CNV. Therefore, patients with these risk factors should be monitored to allow early detection and prompt treatment of secondary CNV.

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Section: Discussionsupporting

confidence: 63%

Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy: OCT Angiography Findings and Risk Factors

Yeo

Kim

et al. 2020

Journal of Ophthalmology

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“…CNV was thought to be a rare complication, but it may occur more prevalently in subjects over the age of 50 years [4] and with chronic CSC [18]. We detected type 1 CNV in 8 eyes (10.7%) of 8 patients (11.4%).…”

Section: Discussionmentioning

confidence: 76%

Detection of Choroidal Neovascularization in Central Serous Chorioretinopathy Using Optical Coherence Tomographic Angiography

Weng¹,

Mao²,

Yu³

et al. 2016

Ophthalmologica

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Purpose: To demonstrate the detection of choroidal neovascularization (CNV) in clinically diagnosed central serous chorioretinopathy (CSC) by optical coherence tomographic angiography (OCTA). Methods: Seventy-five eyes of 70 patients were included. OCTA was performed on each patient. Two trained readers evaluated the images independently to confirm the diagnosis and identify CNV at the level of the outer retina. Results: All studied eyes presented characteristics consistent with CSC based on eye examination and traditional imaging technologies, including fundus fluorescein angiography, which showed no evidence of CNV. However, OCTA revealed definite abnormal vascularization at the level of the outer retina in 8 eyes (10.7%) of 8 patients (11.4%). Conclusion: This study suggests that in some cases of CSC, OCTA could be an alternative option to detect CNV that is undetectable by other conventional imaging techniques.

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“…Possible sequential processes of disease progression in the pachychoroid spectrum are PPE to CSC or PNV or PCV, CSC to PCV or PNV and PNV to PCV. [23][24][25][26] The time flow in this process is supportive of chronicity in eyes with PNV and PCV, which can explain the older age and higher numbers of pachydrusen in PCV and PNV. Other drusen such as reticular pseudodrusen and soft drusen may lead to neovascularization and/or atrophy.…”

Section: Discussionmentioning

confidence: 97%

“…The number of pachydrusen per eye was also higher in PCV and PNV. Possible sequential processes of disease progression in the pachychoroid spectrum are PPE to CSC or PNV or PCV, CSC to PCV or PNV and PNV to PCV . The time flow in this process is supportive of chronicity in eyes with PNV and PCV, which can explain the older age and higher numbers of pachydrusen in PCV and PNV.…”

Section: Discussionmentioning

confidence: 99%

Choroidal morphology under pachydrusen

Baek

Lee

Chung

et al. 2018

Clinical Exper Ophthalmology

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Importance To reveal choroidal morphological profiles under pachydrusen. Background Drusen in pachychoroid disorders show certain differences from conventional drusen and are recently named as “pachydrusen.” This study analysed the specific choroidal morphology under pachydrusen. Design This study is a cross‐sectional case series. Participants Enrolled were 136 eyes with pachydrusen from 134 patients. Methods The presence of pachydrusen in fundus area covered by a 12 × 9 mm2 optical coherence tomography (OCT) image was accessed in eyes with pachychoroid‐related diseases or their fellow eyes using colour fundus photography and swept source OCT. Choroidal morphology under the pachydrusen was analysed using OCT B‐scans and en face images. Main Outcome Measures Choroidal thicknesses and topographical correlation between pachydrusen and pachyvessels. Results A total of 225 pachydrusen in 136 eyes were analysed. The mean number of pachydrusen was 1.65 ± 1.07 per eye. Most pachydrusen were located para‐ or perifoveally (37 subfoveal, 86 parafoveal and 102 perifoveal). The proportion of Haller's layer to total choroidal thickness was higher at the area of the pachydrusen compared to the subfovea (0.881 ± 0.081 vs 0.765 ± 0.111, P < 0.001). In multimodal image analysis, 90.1% of pachydrusen identified using fundus photography and OCT B‐scan were located at the area of a dilated Haller vessel (pachyvessel) seen on en face images. Conclusions and Relevance Choroidal morphology under the pachydrusen showed increased Haller's layer thickness with an attenuated choriocapillaris layer, which is the hallmark of pachychoroid definition. Topographically, their locations correlated with the underlying pachyvessel.

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Choroidal Neovascularization in Caucasian Patients With Longstanding Central Serous Chorioretinopathy

Cited by 51 publications

References 46 publications

Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy: OCT Angiography Findings and Risk Factors

Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy: OCT Angiography Findings and Risk Factors

Detection of Choroidal Neovascularization in Central Serous Chorioretinopathy Using Optical Coherence Tomographic Angiography

Choroidal morphology under pachydrusen

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