Polypoidal Choroidal Vasculopathy

Kim, Joon-Bom; Nirwan, Rajinder S.; Kuriyan, Ajay E.

doi:10.1007/s40135-017-0137-0

Cited by 16 publications

(13 citation statements)

References 156 publications

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“…Combination therapy is often considered to be the one yielding superior results. [1][2][3][4][5][6]10 In our case, favourable outcome in the right eye was achieved with anti-VEGF injections of Bevacizumab only.…”

Section: Discussionmentioning

confidence: 77%

Polypoidal Choroidal Vasculopathy

Nadeem¹

2021

pak J Ophthalmol

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A 76-year-old, hypertensive lady, presented with a three year history of gradual decrease in vision in her right eye. Examination revealed a large, bullous, serous pigment epithelial detachment (PED) of right fovea, a choroidal neovascular membrane, clusters of hard exudates, drusen and surrounding, multifocal, small PEDs. The left eye showed a series of small PEDs mostly on the inferior macula, pigmentary disturbance of the retinal pigment epithelium and scant hard exudates. A diagnosis of Polypoidal choroidal vasculopathy was made. We decided to treat her with intravitreal Bevacizumab injections in her right eye. At 18 months of follow up, her PEDs had resolved and visual acuity had improved from 6/60 OD to 6/36. Key Words: Polypoidal Choroidal Vasculopathy, Age Related Macular Degeneration, Pigment Epithelial Detachment, Choroidal Neovascular Membrane.

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Section: Discussionmentioning

confidence: 77%

Polypoidal Choroidal Vasculopathy

Nadeem¹

2021

pak J Ophthalmol

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“…Various systemic risk factors have been associated with PCV to varying degrees [1,9,41]. Among them, systemic arterial hypertension (HTN) has been singled out in some reports with proportions of patients with HTN ranging between 20% and 70% [30,[36][37][38][39][42][43][44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

“…Because subretinal exudate is a sign of chronicity, our results suggest that the disease has been present for a long period of time prior to presentation at our clinic, likely in a quiescent state. Indeed, a quiescent PCV has been described where exudation and bleeding are absent, with preservation of vision until events such as bleeding and PED occur [1,9]. us, the delayed diagnosis of the disease, which prevented early adequate management, enabled the progression of the disease towards chronicity.…”

Section: Discussionmentioning

confidence: 99%

“…e rapid widespread use of OCT has notably facilitated the diagnosis of the disease in settings where ICGA is not available [4,7]. e treatment of PCV has been the subject of several studies in the past, with a general consensus that combining photodynamic therapy (PDT) with anti-VEGF intravitreal injections is the best therapeutic option [1,8,9].…”

Section: Introductionmentioning

confidence: 99%

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Polypoidal Choroidal Vasculopathy in Congolese Patients

Kabedi

Kayembe

Elongo

et al. 2020

Journal of Ophthalmology

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Purpose. Polypoidal choroidal vasculopathy (PCV) is a visually debilitating disease that mostly affects people of African and Asian heritage. Indocyanine green angiography (ICGA) is the recommended exploratory method for definitive diagnosis. The disease has been extensively described in Asians and Caucasians, but not in Africans. This study was conducted to document the clinical presentation and optical coherence tomography features of polypoidal choroidal vasculopathy (PCV) in Congolese patients. Methods. A prospective case series of patients with PCV was performed between January 2017 and June 2019. Routine ocular examination was performed including best corrected visual acuity measurement, slit-lamp examination, dilated direct fundoscopy, and spectral domain optical coherence tomography (OCT). The diagnosis was based on a combination of clinical and OCT signs. Results. Fourteen patients were diagnosed with PCV during this period. The average age was 64.7 ± 6.9 years. There were 8 females. Ten (71.4%) patients had systemic hypertension. Most patients (n = 9, 64.3%) had bilateral involvement. Blurred vision was the most common complaint (71.4%). The main clinical presentation was subretinal exudates, seen in 19 (82.6%) eyes of 11 (78.6%) patients and subretinal hemorrhage in 10 (43.5%) eyes. Macular localization was found in 16 eyes (69.5%) of 12 (85.7%) patients. Drusen were observed in 35.7% of the patients. On OCT imaging, thumb-like pigment epithelial detachment and subretinal exudation were the most frequent features, observed in 92.9% and 71.4% of the patients, respectively. Conclusions. PCV in Congolese patients showed features that are more similar to those observed in Caucasians. In this setting where indocyanine green angiography is not available, OCT facilitates the diagnosis of PCV.

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“…However, pneumatic displacement of SMH alone does not address the underlying disease; the procedure should be combined with either PDT or intravitreal anti-VEGF. [233234235236237] PDT penetration is limited by the presence of blood and is facilitated with pneumatic displacement to treat the lesion. In cases of thin SMH, anti-VEGF monotherapy alone may be effective and save from rhegmatogenous retinal detachment or choroidal hemorrhage with pneumatic displacement.…”

Section: Treatment Of Submacular Hemorrhagementioning

confidence: 99%

Polypoidal choroidal vasculopathy: An update on current management and review of literature

Palkar

Khetan

2019

Taiwan J Ophthalmol

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Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration (nAMD), commonly seen in the Asian population. It is dissimilar in epidemiology, genetic heterogeneity, pathogenesis, natural history, and response to treatment in comparison to nAMD. Confocal scanning laser ophthalmoscopy-based simultaneous fluorescein angiography and indocyanine green angiography, spectral-domain optical coherence tomography (OCT) with enhanced depth imaging, swept-source OCT, and OCT angiography have improved the ability to detect PCV, understand its pathology, and monitor treatment response. A plethora of literature has discussed the efficacy of photodynamic therapy, anti-vascular endothelial growth factor (VEGF) monotherapy, and combination of both, but only a few studies with higher level of evidence and limited follow-up duration are available. This review discusses the understanding of PCV with respect to epidemiology, pathogenesis, clinical features, natural history, imaging techniques, and various treatment options. Recent clinical trials (EVEREST-II and PLANET study) have emphasized that either anti-VEGF monotherapy or combination treatment is equally capable to strike a balance between polyp regression and stabilization of visual acuity. The recurrent nature of the disease, the development of macular atrophy, and the long-term poor visual prognosis despite treatment are concerns that open avenues for further research.

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Polypoidal Choroidal Vasculopathy

Cited by 16 publications

References 156 publications

Polypoidal Choroidal Vasculopathy

Polypoidal Choroidal Vasculopathy

Polypoidal Choroidal Vasculopathy in Congolese Patients

Polypoidal choroidal vasculopathy: An update on current management and review of literature

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