Polyphyllin I activates AMPK to suppress the growth of non-small-cell lung cancer via induction of autophagy

Wu, Yezi; Su, Yuan; Xiang, Yuchen; Tong, Zhou; Li, Xuewen; Wu, Ming-Wei; Li, Wenjuan; Zhang, Te; Xiang, Ke; Zhang, Liang; Zhao, Hai Tao; Liu, Ying

doi:10.1016/j.abb.2020.108285

Cited by 40 publications

(14 citation statements)

References 32 publications

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“…For instance, thalidezine in various cancer cell lines eliminates apoptotic resistance via autophagic cell death [ 164 ]; four dauricine derivatives induce autophagy-dependent cell death in HeLa cells [ 165 ]. Some natural products in in vivo studies like polyphyllin (PPI) extracted from rhizome Paris polyphylla activate AMPK directly and suppress the growth of non-small-cell lung cancer (NSLC) [ 166 ]. Ethoxysanguinarine, an alkaloid extracted from Macleaya cordata , induces autophagy cell death in breast cancer cells [ 167 ].…”

Section: Autophagy In Cancermentioning

confidence: 99%

Autophagy Paradox of Cancer: Role, Regulation, and Duality

Verma

Bharti

Rafat

et al. 2021

Oxidative Medicine and Cellular Longevity

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Autophagy, a catabolic process, degrades damaged and defective cellular materials through lysosomes, thus working as a recycling mechanism of the cell. It is an evolutionarily conserved and highly regulated process that plays an important role in maintaining cellular homeostasis. Autophagy is constitutively active at the basal level; however, it gets enhanced to meet cellular needs in various stress conditions. The process involves various autophagy-related genes that ultimately lead to the degradation of targeted cytosolic substrates. Many factors modulate both upstream and downstream autophagy pathways like nutritional status, energy level, growth factors, hypoxic conditions, and localization of p53. Any problem in executing autophagy can lead to various pathological conditions including neurodegeneration, aging, and cancer. In cancer, autophagy plays a contradictory role; it inhibits the formation of tumors, whereas, during advanced stages, autophagy promotes tumor progression. Besides, autophagy protects the tumor from various therapies by providing recycled nutrition and energy to the tumor cells. Autophagy is stimulated by tumor suppressor proteins, whereas it gets inhibited by oncogenes. Due to its dynamic and dual role in the pathogenesis of cancer, autophagy provides promising opportunities in developing novel and effective cancer therapies along with managing chemoresistant cancers. In this article, we summarize different strategies that can modulate autophagy in cancer to overcome the major obstacle, i.e., resistance developed in cancer to anticancer therapies.

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Section: Autophagy In Cancermentioning

confidence: 99%

Autophagy Paradox of Cancer: Role, Regulation, and Duality

Verma

Bharti

Rafat

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…is finding was further supported by microscale thermophoresis (MST) and drug affinity responsive targeting stability (DARTS) assays [47].…”

Section: Pharmacological Activities Of Paris Saponinsmentioning

confidence: 79%

Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

Liu

Tian

et al. 2021

Journal of Chemistry

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Rhizoma Paridis, the rhizome of liliaceous plants Paris polyphylla, is one of the most commonly used herbal drugs in China. Phytochemical and pharmacological studies have shown that steroid saponins were the major effective ingredients of Rhizoma Paridis to exert antitumor, anti-inflammatory, hemostasis, and antifibrosis functions. In this review, we discussed the chemical structures of steroid saponins and their related biological activity and mechanisms in cellular and animal models, aiming to provide a reference for future comprehensive exploitation and development of saponins.

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“…Various herbal products were found to exhibit anticancer activity by suppressing cell proliferation and metastasis and inducing cell apoptosis and autophagy ( 23 – 25 ). Previous studies reported that polyphyllin could suppress the progression of multiple human cancers, including lung ( 26 ), gastric ( 27 ), breast ( 28 ) and prostate ( 29 ) cancer. Polyphyllin exerts its roles in cancers by inducing tumor cell apoptosis ( 30 ), suppressing tumor cell proliferation ( 31 ), angiogenesis ( 32 ) and reversing multidrug resistance of tumor cells ( 33 , 34 ).…”

Section: Discussionmentioning

confidence: 99%