Polyphenols: Potential source of drugs for the treatment of ischaemic heart disease

Du, Guanhua; Sun, Lan; Zhao, Rui; Du, Lisheng; Song, Junke; Zhang, Li; He, Guorong; Zhang, Yongxiang; Zhang, Juntian

doi:10.1016/j.pharmthera.2016.04.008

Cited by 57 publications

(34 citation statements)

References 102 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polyphenols have been famous for its various bioactivities such as antioxidant and anti-inflammation functions, free radical scavenging effect and regulating intracellular calcium function [9]. Myricetin (M), a polyphenol monomer, is commonly distributed in berries, vegetables, tea, and wine produced from various plants [10].…”

Section: Introductionmentioning

confidence: 99%

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

Liao

Zhu

Hong

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Diabetic cardiomyopathy (DCM) is associated with a greater risk of mortality in patients with diabetes mellitus. Currently, no specific treatment has been suggested for DCM treatment. This study demonstrated that myricetin (M) attenuated DCM-associated cardiac injury in mice subjected to streptozotocin (SZT) and in neonatal rat cardiomyocytes (NRCM) challenged with high glucose. In vivo investigation demonstrated 6 months of M treatment (200 mg/kg/d) significantly alleviated cardiac hypertrophy, apoptosis, and interstitial fibrosis. Mechanically, M treatment significantly increased the activity of Nrf2/HO-1 pathway, strengthening antioxidative stress capacity evidenced by reversed activities of GPx and SOD, and decreased MDA production. M treatment also inhibited IκBα/NF-κB pathway, resulting in reduced secretion of inflammation cytokines including IL-1β, TNF-α, and IL-6. Besides, the TGFβ/Smad3 signaling was also blunted in DCM mice treated with M. These beneficial effects of M treatment protected cardiomyocytes from apoptosis as shown by decreased TUNEL-positive nucleus, c-caspase 3, and Bax. Similar effects of M treatment could be reproduced in NRCM treated with high glucose. Furthermore, through silencing Nrf2 in NRCM, we found that the regulation of IκBα/NFκB by M was independent on its function on Nrf2. Thus, we concluded that M possesses potential protective effects on DCM through inhibiting IκBα/NFκB and enhancing Nrf2/HO-1.

show abstract

Section: Introductionmentioning

confidence: 99%

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

Liao

Zhu

Hong

et al. 2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies suggest that a polyphenol rich diet may provide protection against coronary heart disease [1,8,14] and lung cancer [15]. Dietary flavonoid intake (such as quercetine, kaempherol and myricetine) proved to decrease the incidence of advanced stage prostate cancer [12].…”

Section: Introductionmentioning

confidence: 99%

Extractability of polyphenols from black currant, red currant and gooseberry and their antioxidant activity

Laczkó-Zöld

Komlósi

Ülkei

et al. 2018

Acta Biologica Hungarica

View full text Add to dashboard Cite

In this study, we analyzed extracts of Ribes (black currant, red currant and gooseberry) fruits obtained with methanol, methanol 50% and water. For each extract total polyphenol content, total flavonoid content and total anthocyanin content was assessed. The antioxidant activity of extracts was evaluated by 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging capacity and by the photo-chemiluminescence (PCL) method. Identification and quantification of individual phenolic compounds was performed by means of high performance liquid chromatograph coupled with diode array detector (HPLC-DAD) analyses. From each fruit, best extraction of polyphenols was obtained with methanol 50%. In case of red currants and gooseberry there was no significant difference in flavonoids and anthocyanins extraction rate by the different extraction solvents. For black currants the methanol and methanol 50% extract presented the highest antioxidant activity. For red currants extracts with methanol 50% showed stronger antioxidant activity (IC = 5.71 mg/ml for DPPH, IC = 1.17 mg/ml for ABTS) than those with methanol or water. In case of gooseberry by the DPPH test the water extract proved to be the most active (IC = 5.9 mg/ml). In the PCL test black currants methanol 50% extract was over 6 times more powerful as the ones from red currants. In case of gooseberries, water extract presented the highest antioxidant activity (41.84 μmol AAE/g). In black currant cyanidin-3-glucoside was the major compound. Quercetin 3-O-glucoside was identified in each sample. From cinnamic acid derivatives neochlorogenic acid was present in black currants in the highest amount (356.33 μg/g).

show abstract

“…), is known to have the function of protecting the heart. Extensive data have shown that resveratrol can prevent thrombosis by reducing oxidative stress and platelet aggregation, thereby protecting blood vessels [ 73 , 74 ].…”

Section: Bioactivities Of Polyphenolsmentioning

confidence: 99%

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

et al. 2020

View full text Add to dashboard Cite

Polyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerability to environmental conditions and low bioavailability, their application in the food and medical fields is greatly limited. Nanoformulations, as excellent drug delivery systems, can overcome these limitations and maximize the pharmacological effects of polyphenols. In this review, we summarize the biological activities of polyphenols, together with systems for their delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based nanoparticles, niosomes, polymers, micelles, emulsions and metal nanoparticles. The application of polyphenol nanoparticles in food and medicine is also discussed. Although loading into nanoparticles solves the main limitation to application of polyphenolic compounds, there are some concerns about their toxicological safety after entry into the human body. It is therefore necessary to conduct toxicity studies and residue analysis on the carrier.

show abstract

Polyphenols: Potential source of drugs for the treatment of ischaemic heart disease

Cited by 57 publications

References 102 publications

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

Extractability of polyphenols from black currant, red currant and gooseberry and their antioxidant activity

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

Contact Info

Product

Resources

About