Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action

Alam, Nur; Almoyad, Muhammad; Huq, Fazlul

doi:10.1155/2018/4154185

Cited by 113 publications

(81 citation statements)

References 285 publications

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“…Some of these studies yielded positive outcomes for what protection against cognitive decline was concerned (reviewed in [84]). The positive effects of plant polyphenols against breast, colon, and colorectal cancer, as emerged from clinical trials, preclinical studies, and primary research, have been recently reviewed critically [85][86][87][88].…”

Section: The Beneficial Effects Of Plant Polyphenols Are Supported Bymentioning

confidence: 99%

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Leri

Scuto

Ontario

et al. 2020

IJMS

311

213

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The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed at reducing the prevalence of these conditions in the population are limited to a safer lifestyle including physical/mental exercise, a reduced caloric intake, and a proper diet in a convivial environment. The claimed health benefits of the Mediterranean and Asian diets have been confirmed in many clinical trials and epidemiological surveys. These diets are characterized by several features, including low meat consumption, the intake of oils instead of fats as lipid sources, moderate amounts of red wine, and significant amounts of fresh fruit and vegetables. In particular, the latter have attracted popular and scientific attention for their content, though in reduced amounts, of a number of molecules increasingly investigated for their healthy properties. Among the latter, plant polyphenols have raised remarkable interest in the scientific community; in fact, several clinical trials have confirmed that many health benefits of the Mediterranean/Asian diets can be traced back to the presence of significant amounts of these molecules, even though, in some cases, contradictory results have been reported, which highlights the need for further investigation. In light of the results of these trials, recent research has sought to provide information on the biochemical, molecular, epigenetic, and cell biology modifications by plant polyphenols in cell, organismal, animal, and human models of cancer, metabolic, and neurodegenerative pathologies, notably Alzheimer’s and Parkinson disease. The findings reported in the last decade are starting to help to decipher the complex relations between plant polyphenols and cell homeostatic systems including metabolic and redox equilibrium, proteostasis, and the inflammatory response, establishing an increasingly solid molecular basis for the healthy effects of these molecules. Taken together, the data currently available, though still incomplete, are providing a rationale for the possible use of natural polyphenols, or their molecular scaffolds, as nutraceuticals to contrast aging and to combat many associated pathologies.

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Section: The Beneficial Effects Of Plant Polyphenols Are Supported Bymentioning

confidence: 99%

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Leri

Scuto

Ontario

et al. 2020

IJMS

311

213

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show abstract

“…Walnuts (genus Juglans) have been shown to suppress colon cancer in mice models through the decreased expression of miR-1903, miR-467c, and miR-3068, as well as the increased expression of miR-297a in athymic nude mice injected subcutaneously with HT-29 CRC cells [520] (Figure 9d) [531-533] have proven efficacy in this situation. Also, Algae derived astaxanthin [534][535][536][537][538][539][540], fucoxanthin [541][542][543][544][545], lutein and zeaxanthin [546][547][548][549], polyphenols [550][551][552][553][554] shown individual excellence (Figure 9). Propolis is a well-known health supplement that is extremely popular in Australia and New Zealand.…”

Section: Mundulea Sericeamentioning

confidence: 99%

Alternative Treatments for Cancer Prevention and Cure [Part 1]

Mohiuddin¹

2019

APCT

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Many lay people along with some so called "key opinion leaders" have a common slogan "There's no answer for cancer". Again, mistake delays proper treatment and make situation worse, more often. Compliance is crucial to obtain optimal health outcomes, such as cure or improvement in QoL. Patients may delay treatment or fail to seek care because of high out-of-pocket expenditures. Despite phenomenal development, conventional therapy falls short in cancer management. There are two major hurdles in anticancer drug development: dose-limiting toxic side effects that reduce either drug effectiveness or the QoL of patients and complicated drug development processes that are costly and time consuming. Cancer patients are increasingly seeking out alternative medicine and might be reluctant to disclose its use to their oncology treatment physicians. But there is limited available information on patterns of utilization and efficacy of alternative medicine for patients with cancer. As adjuvant therapy, many traditional medicines shown efficacy against brain, head and neck, skin, breast, liver, pancreas, kidney, bladder, prostate, colon and blood cancers. The literature reviews non-pharmacological interventions used against cancer, published trials, systematic reviews and meta-analyses.

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“…The bases of CRC hallmarks are genomic instability and inflammation. Genomic instability confers random mutations including chromosomal rearrangements, mutation errors in DNA, genes involved in the control of the cellular cycle, repair, and apoptosis or mutations in tumor suppressor gene such as adenomatous polyposis coli (APC), deleted in CRC (DCC), B-Raf proto-oncogene (BRAF), phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), protein kinase B, and tumor protein (TP53) or the presence oncogenes as Kirsten rat sarcoma (K-ras), and Catenin Beta 1, while the inflammatory state of premalignant and malignant lesions that are driven by cells of the immune system also fosters multiple hallmark functions [3].…”

Section: Pathogenesismentioning

confidence: 99%

“…The prevalence of CRC is higher in developed countries than in developing and undeveloped nations. Adults greater than 50 years are more prone to be affected by CRC, and incidence in males is greater than in females [3]. The CRC incidence and percentage vary from one place to another place in all over the world.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Colorectal Cancer: Implication of Two Medicinal Plants in Their Treatment

Basini¹,

Rayadurgam²,

Dakshinamurthy³

2019

Asian J Pharm Clin Res

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Nowadays, cancer is one of the most common diseases in humans. Among all types, colorectal cancer (CRC) is one of the most serious types diagnosed in men after lung and prostate cancer while in women it occupies the second position after breast cancer worldwide. The risk factors such as obesity, sedentary lifestyle, bad nutritional habits (high in fats and proteins), smoking, and progressive aging are the cause of CRC. The acquisition of abnormal mutations leads to a consisting of many different arrangements of events during the tumor development process. Over the years, different approaches have been employed, in the treatment of cancer. These include chemotherapy, radiotherapy, surgery, and immunotherapy. Chemotherapy is routinely used for cancer treatment, but the toxicity of chemotherapeutics on healthy cells of the human body is obvious. This is the reason for discovering the new, natural origin, substances with potential cytostatic effects and less toxic side effects on the healthy cells. Medicinal plants have a special place in the management of cancer. Numerous cancer research studies have been conducted using traditional medicinal plants to discover new therapeutic agents with fewer side effects. In this review, we are describing two medicinal plants such as Actiniopteris radiata (Sw.) Link (Mayurashikha) and Terminalia pallida Brandis (Tella karaka) (endemic plant) which are available immensely in Chittoor District are used till today by the traditional herbal practitioners, tribal people is near to Talakona forest and Ayurvedic people for various diseases and also for CRC.

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Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action

Cited by 113 publications

References 285 publications

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Alternative Treatments for Cancer Prevention and Cure [Part 1]

An Overview of Colorectal Cancer: Implication of Two Medicinal Plants in Their Treatment

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