Polyphenols from Blossoms of <i>Citrus aurantium</i> L. var. <i>amara</i> Engl. Show Significant Anti-Complement and Anti-Inflammatory Effects

Shen, Chunyan; Jiang, Jianguo; Huang, Chunling; Zhu, Wei; Zheng, Chaoyang

doi:10.1021/acs.jafc.7b03759

Cited by 34 publications

(26 citation statements)

References 50 publications

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“…These HDLs have exclusive characteristics that allow them to deliver cargo to specific targets, suggesting that these lipoproteins play a multi-faceted role in intracellular communication [ 156 ]. Some sterols of dietary origin (particularly plant sterols and hydrophobic antioxidants such as vitamin E, lutein, and zeaxanthin) are absorbed in the intestines in a process that involves the HDL formation pathway; lutein and zeaxanthin are carotenoids with, as well as some polyphenols, potential anti-inflammatory properties, and their absorption could improve the beneficial HDL properties [ 157 , 158 , 159 ].…”

Section: Lipoproteins: Classes and Functionsmentioning

confidence: 99%

Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease

et al. 2018

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High-density lipoproteins (HDL) comprise a heterogeneous family of lipoprotein particles divided into subclasses that are determined by density, size and surface charge as well as protein composition. Epidemiological studies have suggested an inverse correlation between High-density lipoprotein-cholesterol (HDL-C) levels and the risk of cardiovascular diseases and atherosclerosis. HDLs promote reverse cholesterol transport (RCT) and have several atheroprotective functions such as anti-inflammation, anti-thrombosis, and anti-oxidation. HDLs are considered to be atheroprotective because they are associated in serum with paraoxonases (PONs) which protect HDL from oxidation. Polyphenol consumption reduces the risk of chronic diseases in humans. Polyphenols increase the binding of HDL to PON1, increasing the catalytic activity of PON1. This review summarizes the evidence currently available regarding pharmacological and alternative treatments aimed at improving the functionality of HDL-C. Information on the effectiveness of the treatments has contributed to the understanding of the molecular mechanisms that regulate plasma levels of HDL-C, thereby promoting the development of more effective treatment of cardiovascular diseases. For that purpose, Scopus and Medline databases were searched to identify the publications investigating the impact of current therapies focused on high-density lipoproteins.

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Section: Lipoproteins: Classes and Functionsmentioning

confidence: 99%

Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease

et al. 2018

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“…[26][27][28] The pharmacologic potential of Neo includes but not limited to anti-tumor, anti-oxidation, and anti-inflammatory effects. [29][30][31][32][33] In vitro, Neo has been shown to increase the consumption of glucose by HepG2 cells. 34 In vivo, Neo showed both hypoglycemic and hypolipidemic effects on diabetic KK-A y mice.…”

Section: Introductionmentioning

confidence: 99%

Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice

Zhu

Zhang

et al. 2020

FASEB j.

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Obesity and related metabolic disorders are associated with intestinal microbiota dysbiosis, disrupted intestinal barrier, and chronic inflammation. Neohesperidin (Neo), a natural polyphenol abundant in citrus fruits, is known for its preventative and therapeutic effects on numerous diseases. Here, we report that Neo administration attenuates weight gain, low‐grade inflammation, and insulin resistance in mice fed high‐fat diet (HFD). Also, Neo administration substantially restores gut barrier damage, metabolic endotoxemia, and systemic inflammation. Sequencing of 16S rRNA genes in fecal samples revealed that Neo administration reverses HFD‐induced intestinal microbiota dysbiosis: an increase in the diversity of gut microbiota and alteration in the composition of intestinal microbiota (particularly in the relative abundances of Bacteroidetes and Firmicutes). Furthermore, systemic antibiotic treatment abolishes the beneficial effects of Neo in body weight control, suggesting that the effect of Neo on obesity attenuation largely depends on the gut microbiota. More importantly, we demonstrate that the impact of Neo on the regulation of obesity could be transferred from Neo‐treated mice to HFD‐fed mice via fecal microbiota transplantation. Collectively, our data highlight the efficacy of Neo as a prebiotic agent for attenuating obesity, implying a potential mechanism for gut microbiota mediated the beneficial effect of Neo.

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“…These phytochemicals inhibited the overproduction of inflammatory mediators (e.g., TNF-α, IL-1β, IL-4, IL-6, IL-17, and continued prostaglandin E 2 ) and oxidative stress (e.g., nitric oxide, myeloperoxidase, superoxide dismutase, and malonaldehyde) while improving colonic structural damage (e.g., occludin, claudin-1, and zona occludens protein-1). Dihydrophhaseic acid, eriodictyol, isomeranzin, limonin, marmesin, narirutin, nomilin, oxypeucedanin, scoparone, synephrine, and tyramine have anti-inflammatory activities via downregulation of the NF-κB and extracellular-signalregulated kinase pathways in the immune systems of multiple organs [35][36][37][38][39][40]. The anti-inflammatory activities and intestinal protection of the other identified phytochemicals have not yet been reported.…”

Section: Resultsmentioning

confidence: 99%

Preventive Effects of an UPLC-DAD-MS/MS Fingerprinted Hydroalcoholic Extract of Citrus aurantium in a Mouse Model of Ulcerative Colitis

Hwang

Yeul

2018

Planta Med

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Although traditionally used to improve indigestion, diarrhea, dysentery, and constipation, the therapeutic effects of on intestinal inflammation remain unclear. The aim of this study was to evaluate the beneficial effects and to identify the active components of a hydroalcoholic extract of (HECA) on ulcerative colitis. HECA was prepared with 70% ethanol solution in water and extracted at 37 °C for 12 h in triplicate, filtered through a sieve, and lyophilized. Phytochemical identification of HECA was performed by ultra-performance liquid chromatography-diode array detector-tandem mass spectrometry (UPLC-DAD-MS/MS). Animals were randomly assigned to one of four groups based on the treatment conditions. Ulcerative colitis was induced by administration of 2.5% dextran sodium sulfate (DSS) in drinking water for 5 d. Body weight, clinical signs, colon length, pro-inflammatory cytokine expression levels, and histopathological findings were evaluated. In UPLC-DAD-MS/MS analysis, the identified phytochemical components of HECA included four alkaloids, seven coumarins, 18 flavonoids, two lignans, two phenolics, and 10 terpenoids. HECA markedly protected against body weight loss and colon shortening. In pathological examination, HECA alleviated DSS-related mucosal inflammatory lesions in the colon. Moreover, HECA markedly reduced the expression levels of interleukin-6, interferon-, tumor necrosis factor-, and monocyte chemotactic protein-1 in colonic inflammation. Taken together, HECA has potential to relieve mucosal inflammation in the colon, suggesting that the putative active ingredients are responsible for the anti-ulcerative effects.

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Polyphenols from Blossoms of Citrus aurantium L. var. amara Engl. Show Significant Anti-Complement and Anti-Inflammatory Effects

Cited by 34 publications

References 50 publications

Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease

Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease

Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice

Preventive Effects of an UPLC-DAD-MS/MS Fingerprinted Hydroalcoholic Extract of Citrus aurantium in a Mouse Model of Ulcerative Colitis

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