Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice

Lu, Jun; Zhu, Meng Qing; Zhang, Heng; Líu, Hao; Xia, Bo; Wang, Yong Liang; Shi, Xin’e; Peng, Liang; Wu, Jianli

doi:10.1096/fj.201903102rr

Cited by 47 publications

(32 citation statements)

References 71 publications

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“…Lv et al (2015) also noted that naringin and neohesperidin mainly inhibited amylose digestion. In addition, the neohesperidin administration (50 mg/kg/day) attenuates weight gain, low-grade inflammation, and insulin resistance in mice, as well as restored gut barrier damage and metabolic endotoxemia (Lu et al, 2020).…”

Section: Eriocitrinmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Eriocitrinmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…Neohesperidin administration substantially restored gut barrier damage, metabolic endotoxemia, and systemic inflammation. More importantly, it was demonstrated that the regulation of obesity could be transferred from neohesperidin-treated mice to HFD-fed mice via fecal microbiota transplantation [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

Steam Explosion (STEX) of Citrus × Poncirus Hybrids with Exceptional Tolerance to Candidatus Liberibacter Asiaticus (CLas) as Useful Sources of Volatiles and Other Commercial Products

Dorado

Bowman

Cameron

et al. 2021

Biology

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Florida citrus production has declined 75% due to Huanglongbing (HLB), a disease caused by the pathogenic bacterium Candidatus Liberibacter asiaticus (CLas). Methods to combat CLas are costly and only partially effective. The cross-compatible species Poncirus trifoliata and some of its hybrids are known to be highly tolerant to CLas, and thus can potentially serve as an alternative feedstock for many citrus products. To further investigate the commercial potential of citrus hybrids, three citrus hybrids, US-802, US-897, and US-942, were studied for their potential as feedstocks for citrus co-products using steam explosion (STEX) followed by water extraction. Up to 93% of sugars were recovered. US-897 and US-942 have similar volatile profiles to that of the commercial citrus fruit types and as much as 85% of these volatiles could be recovered. Approximately 80% of the pectic hydrocolloids present in all three hybrids could be obtained in water washes of STEX material. Of the phenolics identified, the flavanone glycosides, i.e., naringin, neohesperidin, and poncirin were the most abundant quantitatively in these hybrids. The ability to extract a large percentage of these compounds, along with their inherent values, make US-802, US-897, and US-942 potentially viable feedstock sources for citrus co-products in the current HLB-blighted environment.

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“…Naringin could reduce intestinal inflammation and increase the expression of TJs protein [ 25 , 26 ]. Hesperidin and neohesperidin could maintain the diversity of colonic flora, maintain intestinal microecological balance, and play a beneficial role in intestinal barrier function and gastrointestinal inflammation [ 27 – 29 ]. Therefore, PNS may exert a beneficial effect on the DSS-induced colitis through multiple ways.…”

Section: Discussionmentioning

confidence: 99%

Painong San, a Traditional Chinese Compound Herbal Medicine, Restores Colon Barrier Function on DSS-Induced Colitis in Mice

Rui

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. The intestinal barrier decreases in colitis and restores the integrity of the mucosal barriers that could be used for the treatment of colitis. Painong San (PNS), a traditional Chinese compound herbal medicine originally recorded in “Jingui Yaolve” by Zhongjing Zhang in the Later Han Dynasty, is often used in China and Japan to treat various purulent diseases including intestinal carbuncle. This study was to investigate the effect of PNS on mucosal barrier function in mice with DSS-induced colitis and its related mechanisms. Methods. BALB/C mice were given 3% DSS to induce colitis. The body weight and stool status of the mice were recorded daily, and the histopathological changes of the colon were observed after execution. The permeability of the intestinal mucosa was measured by fluorescein isothiocyanate-dextran 4000, the change of intestinal microbiota was measured by 16S rDNA, and the tight junction-related proteins and Muc-2 were investigated by immunohistochemical or immunofluorescence. The possible signaling pathways were detected by western blot. Results. Compared with the control group, the composition of the microbiota in the PNS group was close to that of the normal group, the number of goblet cells was improved, and the mucosal permeability was significantly reduced. PNS could upregulate the expression of tight junction-related proteins (ZO-1, claudin-1, and occludin) and Muc-2, and at the same time, regulate the Notch pathway. Conclusion. PNS could effectively improve the mucosal barrier function through multiple ways, including restoring the balance of intestine flora, enhancement of the mucous layer barrier, and mechanical barrier function. These protective effects may relate to inhibiting the Notch signaling pathway activated by DSS.

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Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice

Cited by 47 publications

References 71 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

Steam Explosion (STEX) of Citrus × Poncirus Hybrids with Exceptional Tolerance to Candidatus Liberibacter Asiaticus (CLas) as Useful Sources of Volatiles and Other Commercial Products

Painong San, a Traditional Chinese Compound Herbal Medicine, Restores Colon Barrier Function on DSS-Induced Colitis in Mice

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