Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells

Hoang, Van L.T.; Pierson, Jean-Thomas; Curry, Merril; Shaw, P. Nicholas; Dietzgen, Ralf G.; Gidley, Michael J.; Roberts‐Thomson, Sarah J.; Monteith, Gregory R.

doi:10.1007/s10068-015-0035-x

Cited by 20 publications

(12 citation statements)

References 38 publications

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“…As different M. indica varieties have different phytochemical profiles and bioactivities, two studies have evaluated the anti-breast cancer activities of methanolic peel and pulp extracts prepared from three M. indica varieties (Irwin, Kensington Pride and Nam Doc Mai). 52 , 53 Both studies consistently reported Nam Doc Mai peel extract as the only extract with significant cytotoxicity against MCF-7 cells. Additionally, only Nam Doc Mai peel extract was observed to possess significant cell-death inducing activity in MDA-MB-231 cells.…”

Section: Effect Of Extracts Of Various M Indica Parts Against Breast Cancermentioning

confidence: 75%

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Yap¹,

Sekar²,

Seow³

et al. 2021

BCTT

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Globally, breast cancer is the most common cancer type and is one of the most significant causes of deaths in women. To date, multiple clinical interventions have been applied, including surgical resection, radiotherapy, endocrine therapy, targeted therapy and chemotherapy. However, 1) the lack of therapeutic options for metastatic breast cancer, 2) resistance to drug therapy and 3) the lack of more selective therapy for triple-negative breast cancer are some of the major challenges in tackling breast cancer. Given the safe nature of natural products, numerous studies have focused on their anti-cancer potentials. Mangifera indica , commonly known as mango, represents one of the most extensively investigated natural sources. In this review, we provide a comprehensive overview of M. indica extracts (bark, kernel, leaves, peel and pulp) and phytochemicals (mangiferin, norathyriol, gallotannins, gallic acid, pyrogallol, methyl gallate and quercetin) reported for in vitro and in vivo anti-breast cancer activities and their underlying mechanisms based on relevant literature from several scientific databases, including PubMed, Scopus and Google Scholar till date. Overall, the in vitro findings suggest that M. indica extracts and/or phytochemicals inhibit breast cancer cell growth, proliferation, migration and invasion as well as trigger apoptosis and cell cycle arrest. In vivo results demonstrated that there was a reduction in breast tumor xenograft growth. Several potential mechanisms underlying the anti-breast cancer activities have been reported, which include modulation of oxidative status, receptors, signalling pathways, miRNA expression, enzymes and cell cycle regulators. To further explore this medicinal plant against breast cancer, future research directions are addressed. The outcomes of the review revealed that M. indica extracts and their phytochemicals may have potential benefits in the management of breast cancer in women. However, to validate its utility in the creation of innovative and potent therapeutic agents to treat breast cancer, more dedicated research, especially clinical studies are needed to explore the anti-breast cancer potentials of M. indica extracts and their phytochemicals.

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Section: Effect Of Extracts Of Various M Indica Parts Against Breast Cancermentioning

confidence: 75%

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Yap¹,

Sekar²,

Seow³

et al. 2021

BCTT

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“…The hydrolysable tannins in the T. ferdinandiana tissue extracts were determined using the potassium iodate assay previously described by Hoang, et al [23]. Briefly, 50 µL of 1 mg/mL w / v extract was added to a 96-well plate with 150 µL of 2.5% w/v potassium iodate.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant Rich Extracts of Terminalia ferdinandiana Inhibit the Growth of Foodborne Bacteria

Akter

Netzel

Tinggi

et al. 2019

Foods

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Terminalia ferdinandiana (Kakadu plum) is a native Australian plant containing phytochemicals with antioxidant capacity. In the search for alternatives to synthetic preservatives, antioxidants from plants and herbs are increasingly being investigated for the preservation of food. In this study, extracts were prepared from Terminalia ferdinandiana fruit, leaves, seedcoats, and bark using different solvents. Hydrolysable and condensed tannin contents in the extracts were determined, as well as antioxidant capacity, by measuring the total phenolic content (TPC) and free radical scavenging activity using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. Total phenolic content was higher in the fruits and barks with methanol extracts, containing the highest TPC, hydrolysable tannins, and DPPH-free radical scavenging capacity (12.2 ± 2.8 g/100 g dry weight (DW), 55 ± 2 mg/100 g DW, and 93% respectively). Saponins and condensed tannins were highest in bark extracts (7.0 ± 0.2 and 6.5 ± 0.7 g/100 g DW). The antimicrobial activity of extracts from fruit and leaves showed larger zones of inhibition, compared to seedcoats and barks, against the foodborne bacteria Listeria monocytogenes, Bacillus cereus, Methicillin resistant Staphylococcus aureus, and clinical isolates of Pseudomonas aeruginosa. The minimum inhibitory concentration and minimum bactericidal concentration in response to the different extracts ranged from 1.0 to 3.0 mg/mL. Scanning electron microscopy images of the treated bacteria showed morphological changes, leading to cell death. These results suggest that antioxidant rich extracts of Terminalia ferdinandiana fruits and leaves have potential applications as natural antimicrobials in food preservation.

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“…Previous studies reported that mango peel contains a variety of valuable compounds such as polyphenols, carotenoids, enzymes, and dietary fiber [2]. Extracts from mango peel also exhibit antioxidant activity [3], anti-inflammatory activity [4], protection against membrane protein degradation and morphological changes in rat erythrocytes caused by hydrogen peroxide (H 2 O 2 ) [5], antibacterial activity [6], and anticancer activity [7]. Hence, the utilization of mango peels may be an economical means of ameliorating the problem of waste disposal from mango production factories, as well as converting a by-product into material for food, cosmetic, and pharmaceutical industrial usages.…”

Section: Introductionmentioning

confidence: 99%

Free Radical-Scavenging, Anti-Inflammatory, and Antibacterial Activities of Water and Ethanol Extracts Prepared from Compressional-Puffing Pretreated Mango (Mangifera indicaL.) Peels

Huang

Kuo

et al. 2018

Journal of Food Quality

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During the processing of mango, a huge amount of peel is generated, which is environmentally problematic. In the present study, a compressional-puffing process was adopted to pretreat the peels of various mango cultivars, and then the bioactive compounds of mango peels were extracted by water or ethanol. The phenolic compound compositions as well as the free radical-scavenging, antiinflammatory, and antibacterial activities of water extract (WE) and ethanol extract (EE) from nonpuffed (NP) and compressionalpuffed (CP) mango peels were further evaluated. It was found that compressional-puffing could increase the yield of extracts obtained from most mango varieties and could augment the polyphenol content of extracts from Jinhwang and Tainoung number 1 (TN1) cultivars. The WE and EE from TN1 exhibited the highest polyphenol content and the greatest free radical-scavenging activities among the mango cultivars tested. Seven phenolic compounds (gallic acid, pyrogallol, chlorogenic acid, p-hydroxybenzoic acid, p-coumaric acid, ECG, and CG) were detected in CPWE (compressional-puffed water extract) and CPEE (compressionalpuffed ethanol extract) from TN1, and antioxidant stability of both CPWE and CPEE was higher than that of vitamin C. Further biological experiments revealed that CPEE from TN1 possessed the strongest anti-inflammatory and antibacterial activities, and thus it is recommended as a multibioactive agent, which may have applications in the food, cosmetic, and nutraceutical industries.

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Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells

Cited by 20 publications

References 38 publications

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action

Antioxidant Rich Extracts of Terminalia ferdinandiana Inhibit the Growth of Foodborne Bacteria

Free Radical-Scavenging, Anti-Inflammatory, and Antibacterial Activities of Water and Ethanol Extracts Prepared from Compressional-Puffing Pretreated Mango (Mangifera indicaL.) Peels

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