Polyphenolic compounds of a new biologically active extract from immortelle sandy flowers (Helichrysum arenarium (L.) Moench.)

Grinev, Vyacheslav S.; Shirokov, Alexander; Navolokin, Nikita A.; Polukonova, N. V.; Kurchatova, M. N.; Дурнова, Н. А.; Bucharskaya, Alla B.; Maslyakova, Gаlina N.

doi:10.1134/s1068162016070086

Cited by 15 publications

(18 citation statements)

References 3 publications

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“…Compound Class/Name EE DCME ACNE 2',3'-dihydroxypuberulin [31] + 7-(2,3-dihydroxy-3-methylbutoxy)-5-hydroxy-6-methoxy-2H-1-benzopyran-2-one [32] + + coumarin derivative [33,34] [37] + italipyrone [22] + italipyrone analog [22] + γ-pyrone (chromone) 3-(acetyloxy)-2,3-dihydro-5,7-dihydroxy-6-(3-methyl-2-butenyl)-2-phenyl-4H-1-benzopyran-4-one [38] + 2,3-dihydro-5,7-dihydroxy-3-methyl-8-(3-methyl-2-butenyl)-2-(1-methylethyl)-4H-1-benzopyran-4-one [39] + Flavonoid flavone apigenin-7-O-glucoside [4] + apigenin-5-O-glucoside [40] + luteolin [41] + 3,5,6,7,8-pentamethoxyflavone [42] + 3',4',5,6,7-pentamethoxyflavone [43] + apigenin [40] + dihydroxy-dimethoxyflavone [44] + jaceosidin [45] + chrysoeriol [45] + 5,7-dihydroxy-3-methoxyflavone [44] + 5,7,4'-trihydroxy-3,6-dimethoxy-3'-prenylflavone [46] + TEDMF 1 [43] [43] + flavanone naringenin-5-O-glucoside [40] + naringenin-4 -O-glucoside [48] + naringenin-7-O-glucoside [40] + eriodictyol [49] + naringenin [40] + + flavonol quercetin-3-O-glucoside [4], hyperoside (quercetin-3-O-galactoside) [4] + kaempferol-3-O-glucoside [50] + Table 1. Cont.…”

Section: Nomentioning

confidence: 99%

“…Compound Class/Name EE DCME ACNE helichrysoside [51] + quercetin [40] + + tiliroside [52] + tiliroside analog [52] + kaempferol [41] + chalcone arenariumoside V [53], arenariumoside VI [53], arenariumoside VII [53] + tomoroside A [53] + isosalipurposide [40] + helilupolone [54] + Terpenoid sesquiterpenoid sesquiterpene derivative [55][56][57] + sesquiterpene derivative [55][56][57] + sesquiterpene derivative [58][59][60] + sesquiterpene derivative [61,62] + sesquiterpene derivative [62][63][64] + eudesmane derivative [65] + sesquiterpene derivative [66][67][68] + sesquiterpene derivative [66][67][68] + ainsliaside E [69] + cinnamoyloxy-hydroxyeudesmane [70] + athrolide C [71] + + athrolide D [71] + diterpenoid diterpene derivative [30,72] + 8-(acetyloxy)-3-ethenyloctahydro-10-hydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-2,5(3H,4aH)-dione [72] + (7-ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenyl)methyl-butanedioic acid methyl ester [72] + ent-kaurane derivative [73] + gymnospermin …”

Section: Nomentioning

confidence: 99%

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Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Vujić

Vidaković

Jadranin

et al. 2020

Plants

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Helichrysum plicatum DC. is widely used in folk medicine in treating a variety of health disorders. The aim of this study was to examine the influence of different extraction solvents on the chemical composition, antioxidant potential, and antimicrobial activities of H. plicatum. Aerial parts were separately extracted with ethanol, dichloromethane, and sunflower oil. The oil extract (OE) was re-extracted with acetonitrile. A total of 142 compounds were tentatively identified in ethanolic (EE), dichloromethane (DCME), and acetonitrile (ACNE) extracts using HPLC-DAD/ESI-ToF-MS. The dominant compound class in all extracts were α-pyrones, alongside flavonoids in EE, terpenoids in DCME and ACNE, and phloroglucinols in DCME. The antioxidant potential of the extracts was assessed by the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) assay. EE and DCME possessed the most potent radical scavenging capacity. Antimicrobial activity was investigated on eight bacterial, two yeast, and one fungal species. All extracts exhibited high antifungal and notable antibacterial activities compared to control substances, with DCME being the most potent. DCME exhibited stronger antimicrobial activity against P. aeruginosa than the standard chloramphenicol.

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Section: Nomentioning

confidence: 99%

Section: Nomentioning

confidence: 99%

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Vujić

Vidaković

Jadranin

et al. 2020

Plants

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show abstract

“…Apart from direct use of various cultivars for production of food and beverages, animal feed, fabric, ropes etc., pharmaceutics and cosmetics are significant areas of industrial production that involve numerous plants whose genomics have not been yet elucidated. One such plant is immortelle ( Helichrysium arenarium ), a perennial plant widely spread on the Adriatic coast of Croatia, Bosnian and Herzegovina and Montenegro ( 5 , 6 , 7 ). Due to high market value of essential oil of immortelle, and low investments required for its production, agricultural production of this plant has expanded rapidly in the aforementioned regions, especially in in-land Herzegovina, where producers were able to achieve average annual revenues of 19,715.58 BAM (approximately 10,000 EUR) per 1 ha of immortelle ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Overview of Next-generation Sequencing Platforms Used in Published Draft Plant Genomes in Light of Genotypization of Immortelle Plant (Helichrysium Arenarium)

Hodžić¹,

Gurbeta²,

Omanović-Mikličanin³

et al. 2017

Med Arch

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Introduction:Major advancements in DNA sequencing methods introduced in the first decade of the new millennium initiated a rapid expansion of sequencing studies, which yielded a tremendous amount of DNA sequence data, including whole sequenced genomes of various species, including plants. A set of novel sequencing platforms, often collectively named as “next-generation sequencing” (NGS) completely transformed the life sciences, by allowing extensive throughput, while greatly reducing the necessary time, labor and cost of any sequencing endeavor.Purpose:of this paper is to present an overview NGS platforms used to produce the current compendium of published draft genomes of various plants, namely the Roche/454, ABI/SOLiD, and Solexa/Illumina, and to determine the most frequently used platform for the whole genome sequencing of plants in light of genotypization of immortelle plant.Materials and methods:45 papers were selected (with 47 presented plant genome draft sequences), and utilized sequencing techniques and NGS platforms (Roche/454, ABI/SOLiD and Illumina/Solexa) in selected papers were determined. Subsequently, frequency of usage of each platform or combination of platforms was calculated.Results:Illumina/Solexa platforms are by used either as sole sequencing tool in 40.42% of published genomes, or in combination with other platforms - additional 48.94% of published genomes, followed by Roche/454 platforms, used in combination with traditional Sanger sequencing method (10.64%), and never as a sole tool. ABI/SOLiD was only used in combination with Illumina/Solexa and Roche/454 in 4.25% of publications.Conclusions:Illumina/Solexa platforms are by far most preferred by researchers, most probably due to most affordable sequencing costs. Taking into consideration the current economic situation in the Balkans region, Illumina Solexa is the best (if not the only) platform choice if the sequencing of immortelle plant (Helichrysium arenarium) is to be performed by the researchers in this region.

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“…In this work we used extracts which have been obtained by a process of double extraction, followed by alcohol precipitation of non-polar compounds (glycosides and alkaloids, et al) by chloroform from Gratiola officinalis plant, Helichrýsum arenárium and Zea mays [3][4][5]. This method has been patented by us.…”

Section: Description Of the Extractsmentioning

confidence: 99%

“…Previously, we have developed a method for producing flavonoid-containing extracts from Gratīola officinālis, Helichrýsum arenárium, and Zea mays, that allows obtaining non-toxic or slightly toxic extracts even from poisonous plants [3][4][5][6]. It is know that these extracts have antioxidant, antitumor, immunomodulatory [7][8][9][10][11] and antimicrobial [12][13][14] actions.…”

Section: Introductionmentioning

confidence: 99%

Effect of flavonoid-containing extracts on the growth of transplanted sarcoma 45, peripheral blood and bone marrow condition after oral and intramuscular administration in rats

Navolokin¹,

Mudrak²,

Alla³

et al. 2017

Russ Open Med J

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Abstract:Objective -Discovery of the apoptosis-inducing effects of flavonoid vagonin allowed to make an assumption of existence of similar effect in others flavonoids. This study of the effects of extracts from Gratīola officinālis, Helichrýsum arenárium and diploid forms of Zea mays on bone marrow and blood leucocytes at intramuscular and oral administration was carried out on rats bearing sarcoma 45. Earlier, the apoptosis-inducing effects were detected for these extracts but the toxic effects of extracts on blood and bone marrow have not been studied. Therefore, the aim of this study was to investigate the effects of these extracts on white blood cell count and bone marrow morphology. Material and Methods -The experiments were carried out on 48 male Wistar albino rats according to University's Animal Ethics Committee (Protocol № 13, 2011, Saratov, Russia) and the relevant national agency regulating experiments on animals. We evaluated white blood cell count and bone marrow morphology in animals after oral and intramuscular administration of extracts. A growth rate of tumor was also ranked. Results -Oral and intramuscular administration of extracts from flavonoid-containing plants Zea mays and Gratīola officinālis causes normalization of myelocytic germ parameters in bone marrow of tumor-bearing rats and increase of lymphocyte percent in white blood cell count of blood and myelogram. Conclusion -Absence of toxic effects and normalization of myelocytic germ parameters in bone marrow of tumor-bearing rats after oral and intramuscular administration of extracts from flavonoid-containing plants Zea mays and Gratīola officinālis allows to recommend further study of the antitumor effect of these extracts.Keywords: flavonoids, Gratīola officinālis, Helichrýsum arenárium, Zea mays, bone marrow, blood, sarcoma 45Cite as Navolokin NA, Mudrak DA, Bucharskaya AB, Matveeva OV, Tychina SA, Polukonova NV, Maslyakova GN. Effect of flavonoid-containing extracts on the growth of transplanted sarcoma 45, peripheral blood and bone marrow condition after oral and intramuscular administration in rats.

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Polyphenolic compounds of a new biologically active extract from immortelle sandy flowers (Helichrysum arenarium (L.) Moench.)

Cited by 15 publications

References 3 publications

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Composition, Antioxidant Potential, and Antimicrobial Activity of Helichrysum plicatum DC. Various Extracts

Overview of Next-generation Sequencing Platforms Used in Published Draft Plant Genomes in Light of Genotypization of Immortelle Plant (Helichrysium Arenarium)

Effect of flavonoid-containing extracts on the growth of transplanted sarcoma 45, peripheral blood and bone marrow condition after oral and intramuscular administration in rats

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