Polyphenolic Compounds in Human Health with Pharmacological Properties

Selamoğlu, Zeliha

doi:10.4172/2573-4555.1000e138

Cited by 46 publications

(30 citation statements)

References 5 publications

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“…Previous studies have shown that both of them are increased in the heart after MI [ 24 , 25 ] and that dysregulation of the expression of these proteins contributes to collagen remodeling and subsequent cardiac fibrosis following MI [ 26 ]. Propolis was accepted as a traditional medicine; proven to be beneficial to human health [ 27 ] and possess a wide range of biological and pharmacological activities, including antiatherosclerosis [ 28 ], antioxidative stress, and antihypertensive [ 29 ]. FP, the main bioactive compound of propolis [ 30 , 31 ], has been shown to exhibit several cellular activities.…”

Section: Discussionmentioning

confidence: 99%

Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Wang

Sui

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The flavonoid extract from propolis (FP) has been shown to protect against heart injury induced by isoproterenol. However, the effect of FP on cardiac fibrosis after myocardial infarction (MI) as well as the underlying mechanisms is not known. In the present study, we used biochemical and histological approaches to examine the effects of FP on MI-induced cardiac fibrosis and the related mechanisms in a rat MI model and in angiotensin II- (Ang II-) treated rat cardiac fibroblasts (CFs). In vivo, MI was generated by ligation of the left anterior descending coronary artery of rats, which remained for 4 weeks. Rats were randomly divided into the sham, MI, FP (12.5 mg/kg/d), and MI+FP groups. We found that FP treatment improved heart function, reduced cardiac fibrosis, and downregulated the expression of fibrosis-related factors including collagen I, collagen III, matrix metalloproteinase-2 (MMP-2), MMP-9, transforming growth factor-β1 (TGF-β1), and p-Smad2/3, which coincided with the upregulated expression of silent information regulator 1 (SIRT1) in the hearts of MI rats. Our in vitro experiments showed that FP inhibited the proliferation and migration of primary cultured rat CFs and downregulated the expression of the above-mentioned fibrosis-related factors in Ang II-stimulated CFs. In addition, FP can decrease ROS production induced by MI and Ang II in vivo and vitro. Notably, silencing SIRT1 counteracted the FP-induced effects on CFs treated with Ang II. We conclude that FP inhibits MI-induced cardiac fibrosis through SIRT1 activation and that FP represents a potential promising drug for the treatment of MI patients in the clinic.

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Section: Discussionmentioning

confidence: 99%

Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Wang

Sui

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…The total phenolic content, and the identified flavonoids, quercetin, and (‐)epi‐catechin (Figure ) correlates with the phenolic distribution of V. amygdalina leaves (Figure E and F). These properties also portray potent biological activities, as phenols have been recognized as the most influential phytochemical responsible for the medicinal properties of most plants (Lin et al, ; Rasouli, Farzaei, & Khodarahmi, ; Selamoglu, ).…”

Section: Discussionmentioning

confidence: 99%

Histochemistry, phenolic content, antioxidant, and anti-diabetic activities ofVernonia amygdalinaleaf extract

et al. 2018

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Vernonia amygdalina leaves were investigated for their histochemical properties and antidiabetic activities. Histochemical analysis of the leaf revealed distributions of acidic lipid, mucilage, and pectin, lipids, polyphenols, and alkaloids at the mid rib, glandular trichome, and epidermis. HPLC analysis of the leaves hot water infusion revealed the presence of quercetin and (‐)‐epi‐catechin. The infusion had significant (p < 0.05) 2,2′‐diphenyl‐1‐picrylhydrazyl scavenging activity and ferric reducing antioxidant power. Ex vivo antioxidative analysis revealed the ability of the infusion to increase glutathione level, superoxide dismutase, and catalase activities, while concomitantly depleting malondialdehyde level and DNA fragmentation in Fe2+‐induced hepatic injury. The infusion showed significant (p < 0.05) inhibitory activity against α‐glucosidase and pancreatic lipase. It also inhibited intestinal glucose absorption and enhanced muscle glucose uptake, respectively. The ability of the infusion to abate oxidative stress, DNA fragmentation and stimulate muscle glucose uptake may suggest the antioxidative, anti‐apoptotic, and insulin‐sensitizing activity of V. amygdalina. Practical applications Vernonia amygdalina (bitter leaf) is among the common leafy vegetables in West Africa reported for its various medicinal and nutritional properties. It is utilized as a food ingredient as well as supplement for the treatment and management of type 2 diabetes (T2D). Its ability to inhibit intestinal glucose absorption, enhance muscle glucose uptake, and protect against hepatic oxidative stress gives more credence to its reported antidiabetic properties. Being a common leafy vegetable, V. amygdalina can be a cheap source of nutraceutical for the treatment and management of T2D and its complications.

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“…Plants and herbs have been applied in both prevention and treatment of human disorders since ancient times [3][4][5]. Indeed, many investigations on herbs and plants have been conducted, and their efficacy proved as a compelling source of antioxidant, antimicrobial, anti-inflammatory [6], anticancer and neuroprotective agents [7,8].…”

Section: Introductionmentioning

confidence: 99%

Cucurbita Plants: From Farm to Industry

et al. 2019

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The Cucurbita genus, a member of Cucurbitaceae family, also known as cucurbits, is native to the Americas. Genus members, like Cucurbita pepo and Cucurbita maxima, have been used for centuries in folk medicine for treating gastrointestinal diseases and intestinal parasites. These pharmacological effects are mainly attributed to their phytochemical composition. Indeed, Cucurbita species are a natural source of carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, functional carbohydrates, and polysaccharides, that beyond exerting remarkable biological effects, have also been increasingly exploited for biotechnological applications. In this article, we specifically cover the habitat, cultivation, phytochemical composition, and food preservative abilities of Cucurbita plants.

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Polyphenolic Compounds in Human Health with Pharmacological Properties

Cited by 46 publications

References 5 publications

Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1

Histochemistry, phenolic content, antioxidant, and anti-diabetic activities ofVernonia amygdalinaleaf extract

Cucurbita Plants: From Farm to Industry

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