Polyphenolic Compounds, Antioxidant, and Cardioprotective Effects of Pomace Extracts from Fetească Neagră Cultivar

Balea, Ştefania Silvia; Pârvu, Alina Elena; Pop, Nastasia; Marín, Fernando Zamora; Pârvu, Marcel

doi:10.1155/2018/8194721

Cited by 52 publications

(68 citation statements)

References 65 publications

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“…Younis et al reported that ISO in a dose of 85 mg/kg bw decreased in P wave, QRS complex, PR segment, and RR intervals and increased in the QT interval duration and ST-segment deviation, in comparison with the control rats (20). According to results of Soraya et al rats from AMI group treated with ISO in a dose of 100 mg/kg bw showed a marked decrease in R-amplitude, a significant decrease in the RR interval and therefore, a significant increase in the heart rate (21 (13). Rats with ISO-induced AMI had higher levels of CK, CK-MB, ( Table 2) compared to normal rat.…”

Section: Discussionmentioning

confidence: 93%

“…None of the doses of ISO influenced the PR interval ( Table 1). All ISO-induced ECG AMI-like alterations mentioned above could be due to the secondary loss of action potential in the cardyomyocites, as a result of oxidative stress (13). Oxidative stress plays an important role not only in AMI but also in many other cardiovascular disorders (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

“…After ISO administration in all doses, a reduction of RR interval and increased HR were observed on the ECG recordings (Table 1, Figure1). ISO is a beta-adrenoreceptor agonist, and the activation of beta-adrenergic receptors increases not only the HR but also the force of contraction of the left ventricle, stimulating the activity of the heart (13). By accelerating the heart rate, ISO induces impairment in perfusion of the subendocardial myocardium of the left ventricle with secondary subendocardial ischemia, necrosis, and associated ST depression on the ECG (15).…”

Section: Discussionmentioning

confidence: 99%

“…Electrocardiography (ECG) was recorded 24h after the last injection of ISO or saline, using a Biopac MP36 system (Goleta, CA, USA) after the method described by Balea et al (13). The rats were anesthetized with an intraperitoneal injection of ketamine (26 mg/kg bw) and xylazine (2.6 mg kg/bw).…”

Section: Electrocardiographymentioning

confidence: 99%

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Experimental model of acute myocardial infarction for evaluation of prevention and rehabilitation strategies in cardiovascular diseases – a pilot study

Boarescu

Bocşan

et al. 2019

BALNEO

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Introduction: Acute myocardial infarction (AMI) is an important acute disease of myocardial tissue, that occurs as a result of an imbalance between coronary blood supply and myocardial demand. Isoproterenol (ISO) is a synthetic catecholamine, a beta-adrenergic agonist that produces extensive biochemical, functional, and histological alterations in the heart, characteristic for AMI. The present study has been designed to identify the best dose of ISO that induces electrocardiogram (ECG) alterations, enzymatic reaction, and histopathological changes characteristic of AMI. Material and method: AMI was induced to Wistar-Bratislava white male rats, using three different subcutaneous doses of ISO (85 mg/kg bw, 100 mg/kg bw, and 150 mg/kg bw). ISO was administrated twice, with the second dose at 24h after the initial one. The ECGs were recorded at 24 hours after the last dose of ISO. Blood samples were collected for measurement of creatine kinase (CK), and CK-MB serum levels, and the hearts were excised and prepared for histopathologic examination. Results and discussions: All doses of ISO induced alterations in the ECG patterns such as increased heart rate and prolongation of QT and QTc intervals. Depression of the ST segment coupled with marked T wave inversion were observed at the doses of 100 mg/kg bw and 150 mg/kg bw of ISO. All doses of ISO induced an elevation of CK and CK-MB with highest levels observed for the dose of 150 mg/kg bw. Histopathologic examination revealed subendocardial AMI lesions for all doses tested. Conclusions: ISO in doses of 100 mg/kg and 150 mg/kg is useful for induction of infarct-like lesion on ECG, increased levels of myocardial necrosis enzymes and morphological changes characteristic for AMI.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Electrocardiographymentioning

confidence: 99%

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Experimental model of acute myocardial infarction for evaluation of prevention and rehabilitation strategies in cardiovascular diseases – a pilot study

Boarescu

Bocşan

et al. 2019

BALNEO

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“…2. Phenolic compounds exhibit a wide range of physiological properties, such as anti-allergenic, anti-atherogenic, anti-inflammatory, antimicrobial, antioxidant, anti-thrombotic, cardioprotective and vasodilatory effects 8,9,10,11,12 .…”

Section: Fig 1: Plant Of Gynura Crepioidesmentioning

confidence: 99%

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2019

IJPSR

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Gynura crepioides, also known as Okinawa Spinach, belongs to the family Asteraceae, which is known to possess various medicinal properties. The present study was thus aimed at determining the GC-MS based chemical profiling, total phenolic content (TPC), total flavonoid content (TFC) and antioxidant (AO) capacity of the organic crude extracts such as hexane, chloroformethyl acetate, obtained from the extraction of the leaves of G. crepioides by application of Folin-Ciocalteu method, aluminium chloride calorimetric method and DPPH radical scavenging assay, respectively. The results obtained from UV-VIS microplate spectrophotometer indicated a high amount of phenolic and flavonoid content in the leaves. Ethyl acetate extract was found to display highest TPC (10.09 ± 0.20 mg GAE/g) and TFC (9.56 ± 0.22 mg QE/g). Interestingly, ethyl acetate extract also displayed highest AO capacity with IC 50 value of 0.74 mg/mL as compared to chloroform and hexane extracts with IC 50 values of 0.90 mg/mL and 1.50 mg/mL, respectively with respect to the standard BHT (IC 50 =0.04 mg/mL). GC-MS revealed the presence of sulfurous acid, 2ethylhexylisohexyl ester (11.53%) as a major compound in hexane extract, stigmasterol (13.80%) in chloroform extract and squalene (21.32%) in ethyl acetate extract, respectively. The results suggested that G. crepioides has the potential to be a source of alternative medicine due to its reportedly good antioxidant properties. INTRODUCTION: There has been of serious concern about the usage of plant-based drugs. A big ratio of the population still believes and depends on traditional and herbal medicines for their primary healthcare needs. Hence, the need to explore the use of some medicinal plants as alternatives for similar pharmacological effect is of the essence.

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