Polyphenol-Mediated Assembly for Particle Engineering

Zhou, Jiajing; Lin, Zhixing; Ju, Yi; Rahim, Md. Arifur; Richardson, Joseph J.; Caruso, Frank

doi:10.1021/acs.accounts.0c00150

Cited by 301 publications

(231 citation statements)

References 69 publications

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“…Compared to other polyphenol-based supramolecular systems, such as chelation-based nanoparticles (NPs) 24 , the pBDT-TA supramolecular networks allow tailoring of particle size, and they are stable in harsh aqueous environments (chelation-based materials typically disassemble in acid conditions 25 ). Thus, the pBDT-TA particles are envisioned to provide additional versatility and functionality for engineering NPs, while also affording a number of opportunities for subsequent modification.…”

Section: Resultsmentioning

confidence: 99%

Particle engineering enabled by polyphenol-mediated supramolecular networks

et al. 2020

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We report a facile strategy for engineering diverse particles based on the supramolecular assembly of natural polyphenols and a self-polymerizable aromatic dithiol. In aqueous conditions, uniform and size-tunable supramolecular particles are assembled through π–π interactions as mediated by polyphenols. Owing to the high binding affinity of phenolic motifs present at the surface, these particles allow for the subsequent deposition of various materials (i.e., organic, inorganic, and hybrid components), producing a variety of monodisperse functional particles. Moreover, the solvent-dependent disassembly of the supramolecular networks enables their removal, generating a wide range of corresponding hollow structures including capsules and yolk–shell structures. The versatility of these supramolecular networks, combined with their negligible cytotoxicity provides a pathway for the rational design of a range of particle systems (including core–shell, hollow, and yolk–shell) with potential in biomedical and environmental applications.

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Section: Resultsmentioning

confidence: 99%

Particle engineering enabled by polyphenol-mediated supramolecular networks

et al. 2020

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“…Thanks to the antibacterial, antiinflammatory, antioxidant, and anticancer properties as well as the universal adhesion capability of natural tea polyphenols, polyphenols are fast becoming a popular class of molecules that are attracting more researchers to build various materials for bioimaging, therapeutic delivery, and other biomedical applications. [236][237][238][239][240][241][242][243][244][245][246][247][248][249][250][251] Moreover, inspired by the coordination interactions between various metal ions and polyphenols, researchers have also provided a number of functional MPNs to engineer multifunctional nanosystems. [252][253][254][255][256][257][258][259] Here, we have reviewed the structures and classification of natural polyphenols, the synthesis and properties of the polyphenol-containing nanomaterials, and various biomedical applications of polyphenol-based nanosystems.…”

Section: Discussionmentioning

confidence: 99%

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

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Polyphenols, the phenolic hydroxyl group-containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol-containing nanoparticles have attracted extensive research attention due to their antioxidation property, anticancer activity, and universal adherent affinity, and thus have shown great promise in the preparation, stabilization, and modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, and other biomedical applications. Additionally, the metal−polyphenol networks, formed by the coordination interactions between polyphenols and metal ions, have been used to prepare an important class of polyphenol-containing nanoparticles for surface modification, bioimaging, drug delivery, and disease treatments. By focusing on the interactions between polyphenols and different materials (e.g., metal ions, inorganic materials, polymers, proteins, and nucleic acids), a comprehensive review on the synthesis and properties of the polyphenol-containing nanoparticles is provided. Moreover, the remarkable versatility of polyphenol-containing nanoparticles in different biomedical applications, including biodetection, multimodal bioimaging, protein and gene delivery, bone repair, antibiosis, and cancer theranostics is also demonstrated. Finally, the challenges faced by future research regarding the polyphenol-containing nanoparticles are discussed.

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“…We hypothesized that the interactions between individual components in the mixture could create a new entity displaying modified physicochemical properties resulting in novel biological activities. Indeed, the variety of possible interactions between polyphenols (hydrogen, π , hydrophobic, chelating, covalent and electrostatic), discovered during investigations on their application as stabilisers of self-assembled nanoparticles, were shown to produce a range of structures differing in functionality 52 . It was also observed that these phytochemicals usually exert more than one type of stabilising attractive forces.…”

Section: Discussionmentioning

confidence: 99%

Interactions between polyphenolic antioxidants quercetin and naringenin dictate the distinctive redox-related chemical and biological behaviour of their mixtures

Baranowska

Koziara

Suliborska

et al. 2021

Sci Rep

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Food synergy concept is suggested to explain observations that isolated antioxidants are less bioactive than real foods containing them. However, mechanisms behind this discrepancy were hardly studied. Here, we demonstrate the profound impact of interactions between two common food flavonoids (individual: aglycones quercetin—Q and naringenin—N− or their glycosides rutin—R and naringin—N+ vs. mixed: QN− and RN+) on their electrochemical properties and redox-related bioactivities. N− and N+ seemed weak antioxidants individually, yet in both chemical and cellular tests (DPPH and CAA, respectively), they increased reducing activity of mixtures synergistically. In-depth measurements (differential pulse voltammetry) pointed to kinetics of oxidation reaction as decisive factor for antioxidant power. In cellular (HT29 cells) tests, the mixtures exhibited properties of a new substance rather than those of components. Pure flavonoids did not influence proliferation; mixtures stimulated cell growth. Individual flavonoids tended to decrease global DNA methylation with growing concentration; this effect was more pronounced for mixtures, but not concentration-dependent. In nutrigenomic studies, expression of gene set affected by QN− differed entirely from common genes modulated by individual components. These results question the current approach of predicting bioactivity of mixtures based on research with isolated antioxidants.

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Polyphenol-Mediated Assembly for Particle Engineering

Cited by 301 publications

References 69 publications

Particle engineering enabled by polyphenol-mediated supramolecular networks

Particle engineering enabled by polyphenol-mediated supramolecular networks

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Interactions between polyphenolic antioxidants quercetin and naringenin dictate the distinctive redox-related chemical and biological behaviour of their mixtures

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