Polyphenol and Cu2+ surface-modified chitin sponge synergizes with antibacterial, antioxidant and pro-vascularization activities for effective scarless regeneration of burned skin

Li, Zhentao; Huang, Xiuhong; Lin, Licheng; Jiao, Yanpeng; Zhou, Changren; Liu, Zonghua

doi:10.1016/j.cej.2021.129488

Cited by 41 publications

(29 citation statements)

References 74 publications

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“…Most polyphenols have strong antioxidant properties, which can effectively scavenge excess ROS induced by metal ions and maintain the homeostasis of the local microenvironmental. [86,87] Polyphenols can also synergize with metal ions to enhance the antibacterial activity. [71]…”

Section: Mpnsmentioning

confidence: 99%

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Miao

Yang

et al. 2022

Advanced Science

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Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, and antibacterial properties by making use of the coordination between phenolic ligands and metal ions. Further, MPNs have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and excellent antimicrobial properties brought about by polyphenols and metal ions. In this review, different categories of biomaterials based on MPNs (nanoparticles, coatings, capsules, hydrogels) and their fabrication strategies are summarized, and recent research advances in their antimicrobial applications in biomedical fields (e.g., skin repair, bone regeneration, medical devices, etc.) are highlighted.

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Section: Mpnsmentioning

confidence: 99%

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Miao

Yang

et al. 2022

Advanced Science

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“…During the inflammatory phase, immune cells secrete pro-inflammatory cytokines, inducing the production of reactive oxygen species (ROS), such as hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH·) and superoxide anion radical (O 2 ˙ − ), by resident inflammatory cells [ [4] , [5] , [6] ]. Excessive accumulation of ROS in infected wounds can overwhelm the native antioxidant defense system, strengthen the inflammatory reaction, and thus delay wound healing [ 7 , 8 ] and cause scar formation [ [9] , [10] , [11] , [12] ], resulting in skin dysfunction and adverse cosmetic appearance [ 13 ]. ROS-scavenging biomaterials including polyphenols [ 14 , 15 ], nanozymes [ 16 , 17 ], and others, exhibit enhanced therapeutic effects via augmentation of malfunctioning or depleted native antioxidant mechanisms, indicating their utility in the resolution of delayed wound closure and scarless wound healing.…”

Section: Introductionmentioning

confidence: 99%

Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing

Zhao

et al. 2023

Bioactive Materials

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“…Polyphenols have good antioxidant ability through multiple mechanisms, such as scavenging free radicals [ 46 ], activating detoxifying/defensive proteins [ 47 ], etc. PC has been reported as an activator to antioxidative enzymes and the glutathione cycle [ 48 ], especially after chelation with metal ions under suitable conditions [ 30 , 49 ], therefore, a PC-MPN coating was chosen to further investigate the antioxidant properties of the cell response. To simulate an overstressed ROS environment [ 50 , 51 ], 10 mM H 2 O 2 was added to the culture medium as an ROS provider.…”

Section: Resultsmentioning

confidence: 99%

Material priority engineered metal-polyphenol networks: mechanism and platform for multifunctionalities

et al. 2022

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Engineering the surface of materials with desired multifunctionalities is an effective way to fight against multiple adverse factors during tissue repair process. Recently, metal-polyphenol networks (MPNs) have gained increasing attention because of their rapid and simple deposition process onto various substrates (silicon, quartz, gold and polypropylene sheets, etc.). However, the coating mechanism has not been clarified, and multifunctionalized MPNs remain unexplored. Herein, the flavonoid polyphenol procyanidin (PC) was selected to form PC-MPN coatings with Fe3+, and the effects of different assembly parameters, including pH, molar ratio between PC and Fe3+, and material priority during coating formation, were thoroughly evaluated. We found that the material priority (addition sequence of PC and Fe3+) had a great influence on the thickness of the formed PC-MPNs. Various surface techniques (e.g., ultraviolet–visible spectrophotometry, quartz crystal microbalance, X-ray photoelectron spectroscopy, atomic force microscopy, and scanning electron microscopy) were used to investigate the formation mechanism of PC-MPNs. Then PC-MPNs were further engineered with multifunctionalities (fastening cellular attachment in the early stage, promoting long-term cellular proliferation, antioxidation and antibacterial activity). We believe that these findings could further reveal the coating formation mechanism of MPNs and guide the future design of MPN coatings with multifunctionalities, thereby greatly broadening their application prospects, such as in sensors, environments, drug delivery, and tissue engineering. Graphical Abstract

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Polyphenol and Cu2+ surface-modified chitin sponge synergizes with antibacterial, antioxidant and pro-vascularization activities for effective scarless regeneration of burned skin

Cited by 41 publications

References 74 publications

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing

Material priority engineered metal-polyphenol networks: mechanism and platform for multifunctionalities

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