Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells

Kurnianda, Viqqi; Faradilla, S. B.; Karina, Sofyatuddin; Agustina, Sri; Ulfah, Maria; Octavina, Chitra; Syahliza, F; Ramadhan, Muhammad Rizki; Purnawan, Syahrul; Musman, Musri

doi:10.5454/mi.13.2.5

Cited by 3 publications

(4 citation statements)

References 13 publications

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Section: Terpenoids and Steroidsmentioning

confidence: 99%

“…The isocopalanol (49) showed inhibition ability for the PANC-1 cell line with an IC 50 of 0.1 µg/mL [50]. akaterpin (50) has been proven to inhibit PI-PLC (IC 50 of 0.5 µg/mL) and neural sphingomyelinase (IC 50 of 30 µg/mL) [51]. The sulfated meroterpenoids 51-53 are inhibitors of L-APRT at IC 50 of 0.7, 0.7 and 1.05 µM, respectively, [11].…”

Section: Terpenoids and Steroidsmentioning

confidence: 99%

“…The diterpenes callyspinol (48) and isocopalanol (49) were isolated, respectively, from Callyspongia spinosissima (MeOH extract) [49] and Callyspongia sp. (acetone extract) [50]. Compounds 48 and 49 were elucidated by 1 H and 13 C NMR and are structurally different (Figure 2 and Table S2): 48 has only one ring and a double bond, and is monooxygenated, while 49 has a three-membered ring and is saturated and polyoxygenated.…”

Section: Terpenoids and Steroidsmentioning

confidence: 99%

“…[29] Antifouling activity (Barnacle Balanus Amphitrite larvae) Callyspongynic Acid (44) α-glucosidase inhibitor [44] Batyl alcohol (46) Biofilm inhibition (Alteromona macleodii, Ochrobactrum pseudogrignonense, Vibrio harveyi and Staphylococcus aureus) [97] Callyspongamide A ( 47) Cytotoxicity (HeLa cell lines) [46] Isocopalanol (49) Cytotoxicity (PANC-1 cell line) [50] Akaterpin (50) Enzyme Inhibitor (PI-PLC and neural sphingomyelinase) [51] Ilhabelanol (51) Inhibitor of L-APRT [11] Ilhabrene (52) Inhibitor of L-APRT [11] Isoakaterpin (53) Inhibitor of L-APRT [11] (2S,4aS,5S,6R,8aS)-5-(2-((1S,3aS,5R,8aS,Z)-1-hydroxy-1,4,4,6tetramethyl-1,2,3,3a,4,5,8,8a-octahydroazulen-5-yl)-ethyl)-4a,6dimethyloctahydro-2H-chromene-2,6-diol ( 54)…”

Section: Metabolite Name Biological Activitymentioning

confidence: 99%

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Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data

et al. 2021

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The genus Callyspongia (Callyspongiidae) encompasses a group of demosponges including 261 described species, of which approximately 180 have been accepted after taxonomic reviews. The marine organisms of Callyspongia are distributed in tropical ecosystems, especially in the central and western Pacific, but also in the regions of the Indian, the West Atlantic, and the East Pacific Oceans. The reason for the interest in the genus Callyspongia is related to its potential production of bioactive compounds. In this review, we group the chemical information about the metabolites isolated from the genus Callyspongia, as well as studies of the biological activity of these compounds. Through NMR data, 212 metabolites were identified from genus Callyspongia (15 species and Callyspongia sp.), belonging to classes such as polyacetylenes, terpenoids, steroids, alkaloids, polyketides, simple phenols, phenylpropanoids, nucleosides, cyclic peptides, and cyclic depsipeptides. A total of 109 molecules have been reported with bioactive activity, mainly cytotoxic and antimicrobial (antibacterial and antifungal) action. Thus, we conclude that polyacetylenes, terpenoids and steroids correspond to the largest classes of compounds of the genus, and that future research involving the anticancer action of the species’ bioactive metabolites may become relevant.

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Section: Terpenoids and Steroidsmentioning

confidence: 99%

Section: Terpenoids and Steroidsmentioning

confidence: 99%

Section: Terpenoids and Steroidsmentioning

confidence: 99%

Section: Metabolite Name Biological Activitymentioning

confidence: 99%

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Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data

et al. 2021

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Profiles of progesterone and bovine interferon-τ in repeat breeding and non-repeat breeding Aceh cows

et al. 2021

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Aim: This study aimed at determining the profiles of progesterone and bovine interferon-τ (bIFN-τ) and the correlation between the two in repeat breeding (RB) Aceh cattle and non-RB Aceh cattle. Materials and Methods: The study was performed on five RB and five non-RB Aceh cows. These cows were subjected to estrous synchronization using the prostaglandin F2 alpha hormone, which was followed by artificial insemination (AI). Serum samples were collected on days 5, 6, 7, 15, 16, and 17 after AI to measure the concentration of progesterone at the beginning and end of the luteal phase and from days 14 to 18 after AI to measure the concentration of bIFN-τ. The concentrations of progesterone and bIFN-τ were determined using enzyme-linked immunosorbent assay. Pregnancy examinations were performed by ultrasonography on days 25, 35, 45, and 55 after AI. Data for progesterone and bIFN-τ concentrations were analyzed using the Mann–Whitney and t-tests, and the correlation between progesterone and bIFN-τ was analyzed using the Spearman correlation test. Results: The average concentration of progesterone in RB Aceh cows tended to be lower than non-RB Aceh cows, but it was not significantly different (p>0.05). Similar results also found in the concentration of bIFN-τ which RB Aceh cows tended to have lower bIFN-τ concentrations compared to non-RB Aceh cows, but it was also not significantly different (p>0.05). Moreover, the concentrations of progesterone and bIFN-τ in RB and non-RB Aceh cows did not show a significant correlation (p>0.05). These results of the ultrasonography showed that non-RB Aceh cows were pregnant from day 25 to day 55 after AI, whereas RB Aceh cows were not pregnant and had early embryonic death. Conclusion: The concentrations of progesterone and bIFN-τ in non-RB Aceh cows tended to be higher than those in RB Aceh cows, although, it was not significantly different. Non-RB Aceh cows were able to maintain pregnancy until day 55, whereas RB Aceh cows were diagnosed with early embryonic death before day 25 after AI.

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Sea God- Sponges: Toxins and Secondary Metabolites

et al. 2021

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Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells

Cited by 3 publications

References 13 publications

Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data

Metabolities from Marine Sponges of the Genus Callyspongia: Occurrence, Biological Activity, and NMR Data

Profiles of progesterone and bovine interferon-τ in repeat breeding and non-repeat breeding Aceh cows

Sea God- Sponges: Toxins and Secondary Metabolites

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