Polyoxygenated cyclohexane epoxide derivatives from the stem bark of Monanthotaxis buchananii

Antimutagenic constituents fromMonanthotaxis caffra(Sond.) Verdc.

“…The identity of these compounds was further confirmed by comparison of NMR data with those reported in the literature . Crotepoxide has been isolated previously from M. caffra .…”

“…The identity of these compounds was further confirmed by comparison of NMR data with those reported in the literature. [10,26,27] Crotepoxide has been isolated previously from M. caffra. [11] It has also been reported in other members of the Annonaceae family, and was isolated from Friesodielsia obovata [28] and Uvaria purpurea.…”

“…Many antimutagens have been isolated from different plant species including the Annonaceae family. Some members of the Annonaceae contain oxygenated cyclohexane epoxide derivatives such as crotepoxide, senepoxide , senediol, monanthadiepoxide and pipoxide, and these compounds possess tumour inhibitory properties . Furthermore, acetogenins, caryophyllene and caryophyllene‐oxide with anti‐inflammatory and antitumour activities against various cancer cell lines were isolated from members of the Annonaceae family…”

Unusual metabolites from some Tanzanian indigenous plant species

“…Thus, during the past 36 years, several oxygenated cyclohexane epoxides have been obtained from African and South East Asian Uvaria species, which in Africa include U. catocarpa from Madagascar [7], and U. pandensis, U. faulknarae, and U. dependens from Tanzania [8,9]. The natural products have also been obtained from the Annonaceae species, Monanthotaxis species [10], Friesodielsia obovata [11], and Cleistochlamys kirkii [12], as well as from Zingiberaceae [13] and Euphorbiaceae [14] species, thereby suggesting a (chemo) taxonomical relationship between the Annonaceae and the latter two plant families.…”

Phenylbutane Derivatives as Main Constituents ofMonanthotaxis capeaEssential Oil

“…The chemical studies on other species of the same genus, or closely apparented genera, deal onlywith nonvolatile compounds: alkaloids from Popowia cyanocarpa (6), P. pisocava (7,s) and Monanthotaris caulijlora (9), flavonoids from P. caulijlora (10,12) and polyoxygenated cyclohexane epoxide derivatives from M. buchananii (13). …”