Antimutagenic constituents from<i>Monanthotaxis caffra</i>(Sond.) Verdc.

Makhuvele, Rhulani; Foubert, Kenn; Apers, Sandra; Pieters, Luc; Verschaeve, Luc; Elgorashi, E.E.

doi:10.1111/jphp.12918

Cited by 13 publications

(8 citation statements)

References 32 publications

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“…The bioactivities of compound 4 corroborate the previously reported antimicrobial and anticancer activities of some chalcones. , This is the first report of the occurrence of polyoxygenated cyclohexenes in M. trichocarpa , which is of chemotaxonomic importance. The present phytochemical observations support the morphological and phylogenetic placement of this genus to the Uvariae tribe alongside other related genera of the family Annonaceae. − …”

Section: Resultssupporting

confidence: 79%

“…Its leaves and aerial parts are used by the Digo and Giriama communities of Kenya and Tanzania as a remedy for headaches . Previous studies reported the isolation of alkaloids from the twigs of M. trichocarpa and of essential oils and of oxygenated cyclohexene derivatives from various Monanthotaxis species. − The latter are the most common secondary metabolites of the Annonaceae family, particularly of the tribe Uvariae, , and have also been reported to a lesser extent from some other plant families. , Oxygenated cyclohexenes possess antimicrobial activity and have therefore been regarded as viable candidates for drug development . Motivated by the previous work on Monanthotaxis and by the current growing need for new antibacterial agents, we evaluated the activity of the constituents of the roots of M. trichocarpa against Escherichia coli and Bacillus subtilis , as representative Gram-positive and Gram-negative bacterial species, respectively.…”

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confidence: 99%

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Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa

et al. 2020

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Three new oxygenated cyclohexene derivatives, trichocarpeols A (1), B (2), and C (3), along with nine known secondary metabolites, were isolated from the methanolic root extract of Monanthotaxis trichocarpa. They were identified by NMR spectroscopic and mass spectrometric analyses, and the structure of trichocarpeol A (1) was confirmed by single-crystal X-ray diffraction. Out of the 12 isolated natural products, uvaretin (4) showed activity against the Gram-positive bacterium Bacillus subtilis with a MIC value of 18 μM. None of the isolated metabolites was active against the Gram-negative Escherichia coli at a ∼5 mM (2000 μg/mL) concentration. Whereas 4 showed cytotoxicity at EC50 10.2 μM against the MCF-7 human breast cancer cell line, the other compounds were inactive or not tested.

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Section: Resultssupporting

confidence: 79%

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confidence: 99%

Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa

et al. 2020

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“…Although the remaining compounds 4-6 displayed moderate activities on different cell lines, this study was the first to report antiproliferation on four tumor cell lines for 4 and 5. In previous reports, 4 ((+)-crotepoxide) showed antimutagenicity in a Vitotox assay [17] and 1,6-deoxytingtanoxide (5) displayed mild cytotoxicity against human pancreatic cancer cell lines [21]. The bioassay data showed that compound 6 (O-methoxybenzoyl benzoate) did not have significant cytotoxicity on MCF-7; this result correlated with a previous study [22].…”

Section: Evaluation Of the Anticancer Potential Of Isolated Compoundssupporting

confidence: 86%

Bioassay-Guided Isolation and HPLC Quantification of Antiproliferative Metabolites from Stahlianthus thorelii

Nguyen

Lin

et al. 2020

Molecules

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In folk medicine, Stahlianthus thorelii Gagnep. has been used to treat diseases related to inflammation, ulcers, and cancer. There are no reports concerning the chemical components and bioactivities of S. thorelii; thus, this study aims to explore the phytochemicals, quantify the main compounds, and test the anticancer activity of isolates from S. thorelii. Dried rhizomes were extracted with 95% ethanol and, then, partitioned, fractionated, and isolated. On the basis of the result of the antiproliferative activity of the fractions, seven isolates were yielded and were identified by spectroscopic analyses. The inhibition of cancer proliferation was determined by an MTT assay and the deployed IC50 to value their efficacy. Seven compounds containing one new C-benzylated dihydrochalcone derivative, thorechalcone A (1) and 2–7 were isolated from S. thorelii. In terms of the bioactivity, compounds 1 and 3 displayed promising antiproliferative activity (WiDr, A549, and HepG2), with IC50 values <40 µM. The HPLC-UV method of quantification of two major compounds (3 and 4) was also validated. This study presented the isolations of antiproliferative potentials of new chalcone and known flavonoid derivatives from S. thorelii. The validated simple, accurate, and rapid HPLC method could be deployed for the quality control of herbal drugs.

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“…(2019) Annona senegalensis In vitro Inhibited AFB 1 genotoxicity in Ames, Vitotox and comet assays Makhuvele et al. (2018a) Monanthotaxis caffra In vitro Inhibited AFB 1 genotoxicity in vitro Makhuvele et al. (2018b) …”

Section: Mitigation Of Toxigenic Fungi and Mycotoxins Using Botanicalmentioning

confidence: 99%

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

Makhuvele

Naidu

Gbashi

et al. 2020

Heliyon

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Mycotoxins present a great concern to food safety and security due to their adverse health and socio-economic impacts. The necessity to formulate novel strategies that can mitigate the economic and health effects associated with mycotoxin contamination of food and feed commodities without any impact on public health, quality and nutritional value of food and feed, economy and trade industry become imperative. Various strategies have been adopted to mitigate mycotoxin contamination but often fall short of the required efficacy. One of the promising approaches is the use of bioactive plant components/metabolites synergistically with mycotoxin-absorbing components in order to limit exposure to these toxins and associated negative health effects. In particular, is the fabrication of β-cyclodextrin-based nanosponges encapsulated with bioactive compounds of plant origin to inhibit toxigenic fungi and decontaminate mycotoxins in food and feed without leaving any health and environmental hazard to the consumers. The present paper reviews the use of botanicals extracts and their phytochemicals coupled with β-cyclodextrin-based nanosponge technology to inhibit toxigenic fungal invasion and detoxify mycotoxins.

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Antimutagenic constituents fromMonanthotaxis caffra(Sond.) Verdc.

Abstract: Crotepoxide and 5,6-diacetoxy-1-benzoyloxymethyl-1,3-cyclohexadiene have the potential to mitigate the risks arising from consumption of aflatoxin B -contaminated food and feed.

Cited by 13 publications

References 32 publications

Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa

Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa

Bioassay-Guided Isolation and HPLC Quantification of Antiproliferative Metabolites from Stahlianthus thorelii

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

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