Polyoxygenated cembranoids from the South China Sea soft coral Sarcophyton boettgeri and their stereochemistry

Two New Cembranoids from the Chinese Soft Coral Sarcophyton boettgeri**

“…Based on the discrepancy, further research should be conducted to understand the different metabolic formation patterns among diverse metabolites and their actual ecological roles in the life cycle of soft corals. [7] Experimental Section…”

“…It is interesting to note that the uncommon capnosane diterpenes, biogenetically derived from cembranoids through transannular cyclization or ring rearrangement, presented in our previous collection in Weizhou Island [6] but did not be found in the present study. Based on the discrepancy, further research should be conducted to understand the different metabolic formation patterns among diverse metabolites and their actual ecological roles in the life cycle of soft corals [7] …”

“…It is interesting to note that we discovered five uncommon capnosane diterpenes with neuroprotective potency from the title animal collected off the Weizhou Island, Guangxi Zhuang Autonomous Region, China, [6] whereas four new polyoxygenated cembranoids not present in Guangxi collection were obtained from the same species in Ximao Island, Hainan Province, China. [7] Recently, we have encountered S. boettgeri in Weizhou Island. Intrigued by above-mentioned finding, for the purposes to further seek bioactive metabolites and to understand if the geographic factor will impact on their metabolic pattern, a detailed chemical investigation on this collection was carried out, resulting in the isolation of six compounds, including two undescribed cembranoids (1 and 3) and four known related analogs (2 and 5-7) (Figure 1).…”

“…To our knowledge, among all of the reported species of Sarcophyton , there have been no reports regarding the chemical constituents of the title soft coral Sarcophyton boettgeri , except for our two studies in 2022. It is interesting to note that we discovered five uncommon capnosane diterpenes with neuroprotective potency from the title animal collected off the Weizhou Island, Guangxi Zhuang Autonomous Region, China, [6] whereas four new polyoxygenated cembranoids not present in Guangxi collection were obtained from the same species in Ximao Island, Hainan Province, China [7] . Recently, we have encountered S. boettgeri in Weizhou Island.…”

Marine natural products

“…collection. 512 Eight cembranoids, sarcophytembranoids A–H 1297 – 1304 , were isolated from a Ximao Island collection of the soft coral Sarcophyton trocheliophorum ; the study also reported three terpenoid compounds 1305 – 1307 as MNPs for the first time. 513…”