Polyomaviruses KI and WU in Immunocompromised Patients with Respiratory Disease

Mourez, Thomas; Bergeron, Anne; Ribaud, Patricia; Scieux, Catherine; Latour, Régis Peffault de; Tazi, Abdellatif; Socié, Gérard; Simon, François; Goff, Jérôme Le

doi:10.3201/eid1501.080758

Cited by 48 publications

(20 citation statements)

References 15 publications

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“…The possible way of transmission might be respiratory and/or faecal-oral. 2,3,[12][13][14][15][16] The higher PCR prevalence data of immunocompromised patients suggests that immunosuppression might result in reactivation of these viruses, or might establish higher susceptibility to KIPyV and WUPyV infection. 1 It was hypothesized that similarly to BKPyV, transient immunosuppression due to pregnancy might result in higher frequency of WU and/or KI viral infections, but no evidence for it was found during this study.…”

Section: Discussionmentioning

confidence: 99%

“…WU and KI viruses were found in various sample types -respiratory samples, blood, faeces, cerebrospinal fluid, lymphoid tissues, urine -and higher prevalence was observed in children and immunocompromised patients. [12][13][14][15][16] HPyV9 was described from blood and urine samples of kidney transplant patients, then it was found in skin samples, but no in respiratory and faecal samples. 7,17 The higher frequency of these viruses in immunocompromised patients suggests higher susceptibility or reactivation due to immunosuppression.…”

Section: Introductionmentioning

confidence: 99%

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Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Csoma

Sápy

Mészáros

et al. 2012

Journal of Clinical Virology

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26Background: Immunosuppression due to pregnancy may lead to higher susceptibility to 27 infections and reactivation of latent infections, such as BK polyomavirus (BKPyV). There is 28 lack of information about the prevalence of novel human polyomavirus 9 (HPyV9), WU 29 (WUPyV) and KI (KIPyV) during pregnancy. 30Objectives: To study whether pregnancy results in higher prevalence of HPyV9, WUPyV, 31KIPyV and their correlation with BKPyV. 32Study design: Plasma, urine and throat swab samples from 100 pregnant and 100 non 33 pregnant women were screened for the presence of WUPyV, KIPyV, HPyV9 and BKPyV by 34 PCR. 35Results: No WUPyV DNA was detected in plasma, urine and respiratory samples from 36

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Csoma

Sápy

Mészáros

et al. 2012

Journal of Clinical Virology

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“…Prolonged shedding of the virus in children has also been described [Van der Zalm et al, ]. Human polyomavirus 3 has also been isolated from up to 6.5% of children with symptomatic respiratory infections [Mourez et al, ]. Together, this suggests, at a minimum, a role for the virus as a frequent cause of asymptomatic infections, though potential virulence is obviously quite possible, particularly in specific cohorts.…”

Section: Discussionmentioning

confidence: 99%

Complete genome sequence of a KI polyomavirus isolated from an otherwise healthy child with severe lower respiratory tract infection

et al. 2016

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Unbiased, deep sequencing of a nasal specimen from an otherwise healthy 13-month-old boy hospitalized in intensive care revealed high gene expression and the complete genome of a novel isolate of KI polyomavirus (KIPyV). Further investigation detected minimal gene expression of additional viruses, suggesting that KIPyV was potentially the causal agent. Analysis of the complete genome of isolate NMKI001 revealed it is different from all previously reported genomes and contains two amino acid differences as compared to the closest virus isolate, Stockholm 380 (EF127908). J. Med. Virol. 89:926-930, 2017. © 2016 Wiley Periodicals, Inc.

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“…KIPyV or WUPyV viremias were not demonstrable in our series of immunocompromised patients. Whereas the pathogenic potential of KIPyV and WUPyV has not been disclosed, a correlation between immunosuppression and virus reactivation has been suggested . Notably, most studies on the two viruses have been carried out with respiratory samples.…”

Section: Discussionmentioning

confidence: 99%

Polyomaviruses BK, JC, KI, WU, MC, and TS in children with allogeneic hematopoietic stem cell transplantation

Rahiala

Koskenvuo

Sadeghi

et al. 2016

Pediatric Transplantation

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Timely and reliable detection of viruses is of key importance in early diagnosis of infection(s) following allogeneic HSCT. Among the immunocompetent, infections with BKPyV and JCPyV are mostly subclinical, while post-HSCT, the former may cause HC and the latter PML. The epidemiology and clinical impact of the newly identified KIPyV, WUPyV, MCPyV, and TSPyV in this context remain to be defined. To assess the incidence and clinical impact of BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, and TSPyV infections, we performed longitudinal molecular surveillance for DNAemias of these HPyVs among 53 pediatric HSCT recipients. Surveillance pre-HSCT and for three months post-HSCT revealed BKPyV DNAemia in 20 (38%) patients. Our data demonstrate frequent BKPyV DNAemia among pediatric patients with HSCT and the confinement of clinical symptoms to high copy numbers alone. MCPyV and JCPyV viremias occurred at low and TSPyV viremia at very low prevalences. KIPyV or WUPyV viremias were not demonstrable in this group of immunocompromised patients.

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Polyomaviruses KI and WU in Immunocompromised Patients with Respiratory Disease

Cited by 48 publications

References 15 publications

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9

Complete genome sequence of a KI polyomavirus isolated from an otherwise healthy child with severe lower respiratory tract infection

Polyomaviruses BK, JC, KI, WU, MC, and TS in children with allogeneic hematopoietic stem cell transplantation

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