Polyomaviruses BK- And JC-DNA quantitation in kidney allograft biopsies

Costa, Cristina; Bergallo, Massimiliano; Sidoti, Francesca; Astegiano, Sara; Terlizzi, Maria Elena; Mazzucco, Gianna; Segoloni, Giuseppe; Cavallo, Rossana

doi:10.1016/j.jcv.2008.08.006

Cited by 23 publications

(22 citation statements)

References 11 publications

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“…İmmünsüprese hastalarda BK virüs pozitiflik oranının JC virüse göre daha yüksek olduğunu gösteren çalışmalara benzer şekilde bu çalışma-da da BKV DNA pozitifliği (%33.4), JCV DNA pozitifliğine (%4.3) oranla daha yüksek bulunmuştur (7,8) . Saundh ve ark.…”

Section: Discussionunclassified

“…Saundh ve ark. (8) (10) kalp, karaciğer, böbrek nakli olmuş 156 hastayı izlemiş ve idrar örneklerinde %19, kan örnekle-rinde %6 oranında pozitiflik saptamışlardır. Rota ve ark.…”

Section: Discussionunclassified

“…Saundh ve ark. (8) böbrek transplantasyonu sonrası izlenen 30 hastanın 12'sinde (%40) BKV, 5'inde (%16) JCV virüri-si tespit etmişlerdir. BKV tespit edilen hastalardan birinde nefropati gelişmiştir.…”

Section: Discussionunclassified

“…Saundh ve ark. (8) böbrek transplantasyonu sonrası izlenen 30 hastanın 12'sinde BKV (%40), 5'inde JCV (%16) virürisi görüldüğünü bildirmişlerdir. Aynı çalışmada BKV tespit edilen hastalardan birinde nefropati gelişmiş, diğer BKV ve JCV pozitifliği saptanan kişilerde nefropati görülmemiştir.…”

Section: Discussionunclassified

“…Aynı çalışmada BKV tespit edilen hastalardan birinde nefropati gelişmiş, diğer BKV ve JCV pozitifliği saptanan kişilerde nefropati görülmemiştir. Bu durumu ≥10 7 kopya/ml olan BK virüs miktarı ile ilişkilendirmişlerdir (8) . Amerikan Transplantasyon Derneği'nin de verilerine göre idrarda polyomavirus DNA'sının ≥10 7 kopya/ml, plazmada ≥10 4 kopya/ml düze-yinde bulunması durumunda nefropati gelişebil-mektedir (15) .…”

Section: Discussionunclassified

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Investigation of BK and JC Virus DNA Positivities by Real-Time Polymerase Chain Reaction in Immunosuppressive Patients

ÇOLAK¹,

ALTAY²,

ERTEN³

et al. 2015

TMCD

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Anahtar kelimeler: BK-JC virüs, immünsüpresif hasta, gerçek zamanlı polimeraz zincir reaksiyonu SUMMARY Investigation of BK and JC Virus DNA Positivities by Real-Time Polymerase Chain Reaction in Immunosuppressive Patients Aim: This study was aimed to investigate the BK virus (BKV) and JC virus (JCV) DNA by real-time polymerase chain reaction (Real-Time PCR) in immunosuppressive patients with high risk. Materials and Methods: A total of 296 samples obtained from 129 patients hospitalized in Gazi University

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Section: Discussionunclassified

“…Saundh ve ark. (8) (10) kalp, karaciğer, böbrek nakli olmuş 156 hastayı izlemiş ve idrar örneklerinde %19, kan örnekle-rinde %6 oranında pozitiflik saptamışlardır. Rota ve ark.…”

Section: Discussionunclassified

See 3 more Smart Citations

Investigation of BK and JC Virus DNA Positivities by Real-Time Polymerase Chain Reaction in Immunosuppressive Patients

ÇOLAK¹,

ALTAY²,

ERTEN³

et al. 2015

TMCD

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Molecular detection and characterization of BK and JC polyomaviruses in urine samples of renal transplant patients in Southern Brazil

Comerlato

Campos

Oliveira

et al. 2014

Journal of Medical Virology

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The human polyomaviruses JC (JCPyV) and BK (BKPyV) are widespread in the human population. Following the primary infection, virus reactivation may lead to nephropathy and graft rejection in renal transplant patients. This study was carried out to access the presence of BKPyV and JCPyV DNA in urine samples collected from renal transplant patients (n = 92) and healthy individuals (n = 88) in Porto Alegre, Rio Grande do Sul. The samples were submitted to a nested PCR. A significantly higher frequency (P < 0.001) of BKPyV was found in renal transplant patients (65.2%) in comparison to the control group (32.9%). JCPyV was detected equally in both groups. Phylogenetic analysis of both BKPyV and JCPyV amplicons demonstrates the presence of the BKPyV subtypes I and II, whereas for JCPyV, four different groups are found (1, 2, 3, and 4).

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BK and JC polyomavirus infections in Tunisian renal transplant recipients

Boukoum¹,

Nahdi²,

Sahtout

et al. 2015

J. Med. Virol.

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The aim of this prospective study was to investigate the rate of BK (BKPyV) and JC (JCPyV) polyomavirus infections and their influence on allograft function in Tunisian renal transplant recipients. A total of 72 renal transplant recipients were studied. BKPyV and JCPyV were detected and quantified by real-time PCR in urine and plasma. Demographic and laboratory characteristics were collected for each patient. Polyomavirus DNAuria was detected in 54 (75%) of renal transplant recipients: 26 (36%) had BKPyV DNAuria, 20 (28%) had JCPyV DNAuria, and 8 (11%) had a dual BKPyV/JCPyV DNAuria. BKPyV DNAemia was detected in four (5.5%) patients, whereas no patient had JCPyV viremia. More than 70% of BKPyV and JCPyV infections started within the first 3 months post-transplant. The risk for positive DNAemia was observed in patients with DNAuria level >10(7) copies/ml. BK Polyomavirus-associated nephropathy (BKPyVAN) was observed in two patients. This study highlights the high frequency of BKPyV and JCPyV viruria during the first year post-transplant with the highest incidence observed in the third month. We identified several risk factors that were associated with BKV DNAuria including age, sex of patients, and the use of tacrolimus instead of cyclosporine A at month 3. The use of cyclosporine A instead of tacrolimus was identified as risk factor for JCV viruria in month 3. No statistical difference in the allograft function was found between BKPyV and/or JCPyV infected and uninfected patients.

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Polyomaviruses BK- And JC-DNA quantitation in kidney allograft biopsies

Cited by 23 publications

References 11 publications

Investigation of BK and JC Virus DNA Positivities by Real-Time Polymerase Chain Reaction in Immunosuppressive Patients

Investigation of BK and JC Virus DNA Positivities by Real-Time Polymerase Chain Reaction in Immunosuppressive Patients

Molecular detection and characterization of BK and JC polyomaviruses in urine samples of renal transplant patients in Southern Brazil

BK and JC polyomavirus infections in Tunisian renal transplant recipients

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