Polyneuropathy in lithium intoxication

Vanhooren, Geert; Dehaene, Ides; Zandycke, Michel Van; Piessens, Frans; Vandenbergh, Vic; Hees, J. Van; Lammens, Martin; Carton, Herwig

doi:10.1002/mus.880130306

Cited by 16 publications

(3 citation statements)

References 15 publications

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“…Ibudilast, a phosphodiesterase inhibitor, is used to treat bronchial asthma [137]. Considering the successful administration in several cases of sensory-motor neuropathy [138–140]. Beneficial effects of ibudilast treatment in rat models of neuropathic pain were also reported [141, 142].…”

Section: Ncs-1 In Disorders and Diseasesmentioning

confidence: 99%

NCS-1 is a regulator of calcium signaling in health and disease

Boeckel

Ehrlich

2018

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Neuronal Calcium Sensor-1 (NCS-1) is a highly conserved calcium binding protein which contributes to the maintenance of intracellular calcium homeostasis and regulation of calcium-dependent signaling pathways. It is involved in a variety of physiological cell functions, including exocytosis, regulation of calcium permeable channels, neuroplasticity and response to neuronal damage. Over the past 30 years, continuing investigation of cellular functions of NCS-1 and associated disease states have highlighted its function in the pathophysiology of several disorders and as a therapeutic target. Among the diseases that were found to be associated with NCS-1 are neurological disorders such as bipolar disease and non-neurological conditions such as breast cancer. Furthermore, alteration of NCS-1 expression is associated with substance abuse disorders and severe side effects of chemotherapeutic agents. The objective of this article is to summarize the current body of evidence describing NCS-1 and its interactions on a molecular and cellular scale, as well as describing macroscopic implications in physiology and medicine. Particular attention is paid to the role of NCS-1 in development and prevention of chemotherapy induced peripheral neuropathy (CIPN).

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Section: Ncs-1 In Disorders and Diseasesmentioning

confidence: 99%

NCS-1 is a regulator of calcium signaling in health and disease

Boeckel

Ehrlich

2018

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

View full text Add to dashboard Cite

show abstract

“…Acute denervation activity with larger motor units and higher fiber density later on, together with only moderately slowed nerve conduction velocities indicate axonal neuropathy. [ 3 6 ] A possible mechanism of lithium-induced neuropathy would be an intracellular accumulation of lithium and interference with the propagation of action potentials. [ 7 ] Lithium-induced neuropathy should be distinguished from neurological features associated with lithium intoxication.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 ] Most cases of polyneuropathy were reported with lithium intoxication. [ 3 4 ] Very few cases of peripheral nervous system damage secondary to lithium (with normal serum lithium levels) are reported. [ 5 ] We present a case of motor neuropathy due to the use of lithium in a 26-year-old male with a therapeutic lithium level.…”

Section: Introductionmentioning

confidence: 99%