Lithium-Induced Motor Neuropathy: An Unusual Presentation

Mohapatra, Satyakam; Sahoo, Manas Ranjan; Rath, Neelmadhav

doi:10.4103/0253-7176.183076

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Ibudilast, a phosphodiesterase inhibitor, is used to treat bronchial asthma [137]. Considering the successful administration in several cases of sensory-motor neuropathy [138–140]. Beneficial effects of ibudilast treatment in rat models of neuropathic pain were also reported [141, 142].…”

Section: Ncs-1 In Disorders and Diseasesmentioning

confidence: 99%

NCS-1 is a regulator of calcium signaling in health and disease

Boeckel

Ehrlich

2018

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Neuronal Calcium Sensor-1 (NCS-1) is a highly conserved calcium binding protein which contributes to the maintenance of intracellular calcium homeostasis and regulation of calcium-dependent signaling pathways. It is involved in a variety of physiological cell functions, including exocytosis, regulation of calcium permeable channels, neuroplasticity and response to neuronal damage. Over the past 30 years, continuing investigation of cellular functions of NCS-1 and associated disease states have highlighted its function in the pathophysiology of several disorders and as a therapeutic target. Among the diseases that were found to be associated with NCS-1 are neurological disorders such as bipolar disease and non-neurological conditions such as breast cancer. Furthermore, alteration of NCS-1 expression is associated with substance abuse disorders and severe side effects of chemotherapeutic agents. The objective of this article is to summarize the current body of evidence describing NCS-1 and its interactions on a molecular and cellular scale, as well as describing macroscopic implications in physiology and medicine. Particular attention is paid to the role of NCS-1 in development and prevention of chemotherapy induced peripheral neuropathy (CIPN).

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Section: Ncs-1 In Disorders and Diseasesmentioning

confidence: 99%

NCS-1 is a regulator of calcium signaling in health and disease

Boeckel

Ehrlich

2018

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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“…Studies done from India focused on assessing the adverse effects and safety/tolerability profile of lithium,[101112131415] and most of the data are in the form of case reports. [161718] The issue of pattern of lithium prescription from India is underexplored till now. Hence, we decided to understand the knowledge, attitude, and practice of lithium by a subset of psychiatrists in India, which will help us understand the theory–practice gap and for devising strategies to bridge the existing gap.…”

Section: Introductionmentioning

confidence: 99%

Perspectives, attitude, and practice of lithium prescription among psychiatrists in India

Mandal

Mamidipalli

Mukherjee

et al. 2019

Indian J Psychiatry

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Introduction:Lithium “the magic pill” past its discovery remained the respite for patients with bipolar disorders for decades. The prescriptions of lithium were replaced by other drugs because of the cumbersome monitoring, adverse effect profile, narrow therapeutic index, and frequent comorbidities in patients. The objectives of this study were to understand the knowledge, attitude, and practice of lithium by a subset of psychiatrists in India, which will help us understand the theory–practice gap and for devising strategies to bridge the existing gap.Materials and Methods:The current study was an online survey which included 103 psychiatrists from India of either gender and any age group. Predesigned questionnaire about the knowledge, attitude, and practice of lithium use was circulated for 1 month (March 2018). We received 135 responses (31% response rate), of which 32 were incomplete. Hence, the total sample of psychiatrists included in the study was 103.Results:The results suggest that most practitioners included in the survey had knowledge about the effects, adverse effects, and the monitoring protocols and were comfortable in using lithium in patients on outpatient basis. Despite being aware of the indications, the psychiatrists were skeptical in starting lithium due to multitude of perceived barriers such as comorbidities, patient's low adherence to blood monitoring, and adverse effects.Conclusions:Clinicians should be well aware of the adverse effects, monitoring protocols, which will help them to use lithium in a more appropriate manner.

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Lithium-Induced Motor Neuropathy: An Unusual Presentation

Cited by 2 publications

References 5 publications

NCS-1 is a regulator of calcium signaling in health and disease

NCS-1 is a regulator of calcium signaling in health and disease

Perspectives, attitude, and practice of lithium prescription among psychiatrists in India

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