Polymyxins and Circulin

Sebek, Oldrich K.

doi:10.1007/978-3-662-38439-8_9

Cited by 14 publications

(8 citation statements)

References 42 publications

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“…Dactinomycin showed synergism not only with colistin, which increases membrane permeability (16), but also with nalidixic acid, which inhibits the synthesis of nuclear deoxyribonucleic acid in susceptible bacteria (11). Both nalidixic acid and colistrin antagonized the bactericidal effect of mitomycin C, a drug which inhibits deoxyribonucleic acid synthesis.…”

Section: Discussionmentioning

confidence: 99%

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Bactericidal Effect of Combinations of Antimicrobial Drugs and Antineoplastic Antibiotics Against Staphylococcus aureus

Jacobs

Michel

Sacks

1979

Antimicrob Agents Chemother

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Six antineoplastic antibiotics were tested against ten strains of Staphylococcus aureus. Four lin G for two of these nine strains were 16 and 64 ug/ ml, respectively, and for seven strains MBCs were 256 iLg/ml or higher. Strain 10 was S. aureus [Oxford] NCTC 6571, a non-penicillinas producer. The MBC of penicillin G was 1.0 pug/mL) Minimum inhibitory concentrations/MBCs were determined by using serial dilutions of both the antibacterial and the antineoplastic drugs inoculated with an overnight culture of the organism to give a final concentration of 106 bacteria per ml.

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Section: Discussionmentioning

confidence: 99%

“…Each of 16 antibacterial drugs was combined with each of 6 antineoplastic antibiotics, all of which are in routine clinical use, and the 96 combinations were screened against 10 strains of S. aureus, using the cellophane transfer technique (3) as modified by Cluzel et al (6).…”

Section: Methodsmentioning

confidence: 99%

Bactericidal Effect of Combinations of Antimicrobial Drugs and Antineoplastic Antibiotics Against Staphylococcus aureus

Jacobs

Michel

Sacks

1979

Antimicrob Agents Chemother

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“…Polymyxin B is known to interact with lipids and phospholipids (35,36) and has been reported to prevent the Shwartzman phenomenon (37) possibly by inactivating endotoxin. Polymyxin B has been also shown to inhibit brain tissue factor activity allegedly by binding with the phospholipid moiety of tissue factor (38).…”

Section: Discussionmentioning

confidence: 99%

Coagulant Activity of Leukocytes. TISSUE FACTOR ACTIVITY

Niemetz¹

1972

J. Clin. Invest.

172

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“…Accordingly, it was thought that a complex of himastatin with (500 ,ug/ml) plus fatty acid sodium salt (4,000 ,ug/ml); O, fatty acid sodium salt (4,000 ,ug/ml [control] Attempts were made to demonstrate similar effects between fatty acid salts and a number of other antibiotics. Of these, only polymyxin B, a membrane-active peptide antibiotic (6,19,20), showed a marked decrease in antibacterial activity in the presence of fatty acid sodium salts. Interestingly, polymyxin E (colistin) did not show any such decrease despite its very similar structure.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of antibacterial activity of himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus, by fatty acid sodium salts

Mamber

Brookshire

Dean

et al. 1994

Antimicrob Agents Chemother

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Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. An Himastatin is a dimeric cyclohexadepsipeptide antibiotic isolated from fermentation broths of Streptomyces hygroscopicus (9, 10). The proposed structure of himastatin is shown in Fig. 1. The compound had antimicrobial activity against grampositive bacteria and was cytotoxic to mammalian tumor cell lines in vitro. Himastatin also was active against both murine P388 leukemia and B16 melanoma (intraperitoneal-intraperitoneal [i.p.-i.p.] models) (9). However, activity was not obtained against intravenously implanted P388. It was hypothesized that the lack of distal site antitumor activity in vivo resulted from either poor bioavailability or metabolic inactivation. A soluble formulation of himastatin was developed; this preparation was active against P388 in the i.p.-i.p. model but also was inactive in the intravenous-intravenous P388 model. The metabolic inactivation hypothesis then was evaluated with an in vitro model on the basis of activity against Bacillus subtilis. It was found that mouse liver homogenates markedly inhibited the activity of himastatin against B. subtilis. However, it was demonstrated further that the inhibitory effects were not metabolic or enzymatic in nature. Thus, the purpose of this research was to investigate the nature of the inhibition of B. subtilis activity by himastatin in the presence of liver homogenates.

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Polymyxins and Circulin

Cited by 14 publications

References 42 publications

Bactericidal Effect of Combinations of Antimicrobial Drugs and Antineoplastic Antibiotics Against Staphylococcus aureus

Bactericidal Effect of Combinations of Antimicrobial Drugs and Antineoplastic Antibiotics Against Staphylococcus aureus

Coagulant Activity of Leukocytes. TISSUE FACTOR ACTIVITY

Inhibition of antibacterial activity of himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus, by fatty acid sodium salts

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