Antibiotics 1967
DOI: 10.1007/978-3-662-38439-8_9
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Polymyxins and Circulin

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1970
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Cited by 14 publications
(8 citation statements)
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“…Dactinomycin showed synergism not only with colistin, which increases membrane permeability (16), but also with nalidixic acid, which inhibits the synthesis of nuclear deoxyribonucleic acid in susceptible bacteria (11). Both nalidixic acid and colistrin antagonized the bactericidal effect of mitomycin C, a drug which inhibits deoxyribonucleic acid synthesis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Dactinomycin showed synergism not only with colistin, which increases membrane permeability (16), but also with nalidixic acid, which inhibits the synthesis of nuclear deoxyribonucleic acid in susceptible bacteria (11). Both nalidixic acid and colistrin antagonized the bactericidal effect of mitomycin C, a drug which inhibits deoxyribonucleic acid synthesis.…”
Section: Discussionmentioning
confidence: 99%
“…Each of 16 antibacterial drugs was combined with each of 6 antineoplastic antibiotics, all of which are in routine clinical use, and the 96 combinations were screened against 10 strains of S. aureus, using the cellophane transfer technique (3) as modified by Cluzel et al (6).…”
Section: Methodsmentioning
confidence: 99%
“…Polymyxin B is known to interact with lipids and phospholipids (35,36) and has been reported to prevent the Shwartzman phenomenon (37) possibly by inactivating endotoxin. Polymyxin B has been also shown to inhibit brain tissue factor activity allegedly by binding with the phospholipid moiety of tissue factor (38).…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, it was thought that a complex of himastatin with (500 ,ug/ml) plus fatty acid sodium salt (4,000 ,ug/ml); O, fatty acid sodium salt (4,000 ,ug/ml [control] Attempts were made to demonstrate similar effects between fatty acid salts and a number of other antibiotics. Of these, only polymyxin B, a membrane-active peptide antibiotic (6,19,20), showed a marked decrease in antibacterial activity in the presence of fatty acid sodium salts. Interestingly, polymyxin E (colistin) did not show any such decrease despite its very similar structure.…”
Section: Discussionmentioning
confidence: 99%