Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism

Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance

“…It means that the water soluble m-CS in this work is hard to deposit on the surface of E. coli , leading to a relatively low antibacterial rate in the UV-CS unloaded area (66.94% when compared with Ti-MAO). As for the gram-positive bacteria like S. aureus , the antibacterial mechanism is that the positive charge of chitosan interacts with the negative charge at the surface of bacteria, leading to the loss of the normal physiological function of the bacteria [ 39 ]. Herein, the water soluble m-CS can interacts with the surface of S. aureus as expected, thus only several one with small size has been observed in the Fig.…”

The Role of Hitchhiking in Cancer Therapeutics—A Review

“…[8] Thus, such a preventative nanoparticle coating layer (Figure 4Da) can help bacteria escape lysosomes, strengthen acid tolerance, and tremendously enhance bacteria spread into the bloodstream upon oral ingestion (Figure 4Db). [8,192,202] In comparison to conventional bacterial delivery systems, where surface modification of both bacteria and nanoparticles is essential before assembly, the self-assembly strategy of nanoparticle-coated bacteria is considerably easier and more practical. [8]…”

Current synthetic chemistry towards cyclic antimicrobial peptides

“…Biological evaluation of these analogues disclosed that cyclic peptides with more than five charges displayed loss of antibacterial activity while peptides with less than four charges exhibited high hemolytic activity. Among the 10 analogues, they found one peptide cyclo‐(fPFfOOOOOL) (Figure 2) with five positive charges had potent activities against both Gram‐negative and Gram‐positive bacteria in vitro and in vivo with no obvious hemolytic activity 16 …”

“…Among the 10 analogues, they found one peptide cyclo-(fPFfOOOOOL) (Figure 2) with five positive charges had potent activities against both Gram-negative and Grampositive bacteria in vitro and in vivo with no obvious hemolytic activity. 16 Fusaricidins/LI-Fs family of natural products are cyclic lipodepsipeptide isolated from Paenibacillus sp with potential antifungi and anti-bacterial activity. 17,18 Fusaricidins/LI-Fs have simple structure containing only six amino acid residues and a lipid tail, which make them attractive candidates for the development of novel antimicrobial agents.…”