Polymorphous low‐grade adenocarcinoma of minor salivary glands: a study of 17 cases with emphasis on cell differentiation

Perez-Ordoñez, Bayardo; Linkov, Irina; Huvos, Andrew G.

doi:10.1046/j.1365-2559.1998.t01-2-00410.x

Cited by 88 publications

(82 citation statements)

References 27 publications

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“…Two of these five cases had a papillary appearance, and Fig. 4a, b of this paper show a tumor with an appearance very similar if not identical to that of CATMSG [15]. It is reasonable to speculate that the tumor pictured in these two figures is likely to be a CATMSG.…”

Section: Differential Diagnosissupporting

confidence: 50%

“…The literature records several possible examples of CATMSG published as PLGA or under other names. Perez-Ordonez et al [15] described 17 PLGAs among which there were two examples of ''PLGA'' of the tongue. In this series, there was a much higher metastatic rate than is usual for PLGA, as 5 of the 17 cases had secondaries in the neck lymph nodes.…”

Section: Differential Diagnosismentioning

confidence: 99%

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Cribriform Adenocarcinoma of the Tongue and Minor Salivary Glands: A Review

Michal

Kacerovská

Kazakov

2013

Head and Neck Pathol

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Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a tumor occurring mostly, but not exclusively, in the base of the tongue. Other locations are minor salivary glands of the oral cavity. Histopathologically, CATMSG resembles papillary carcinoma of the thyroid gland. It usually reveals a solid growth devoid of colloid, and eosinophilic material present in follicular areas is rather pale in contrast to metastatic foci seen in papillary thyroid carcinoma that shows typical deeply eosinophilic colloid with ''moth-eaten peripheries'' and cystic configuration. In addition, giant multinucleated cells are not observed in CATMSG and psammoma bodies are found only exceptionally. Unlike papillary thyroid carcinoma, CATMSG is composed of hybrid secretorymyoepithelial cells. Most importantly, CATMSG is consistently negative with both thyroglobulin and TTF-1. CATMSG is a distinct tumor entity that also differs from polymorphous low-grade adenocarcinoma by location, cytology, histological architecture, and behavior, with frequent metastases at the time of presentation. Paradoxically, early metastatic disease seen in most cases of CATMSG is associated with an indolent behavior. It makes CATMSG a unique neoplasm among all low-grade salivary gland tumors.

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Section: Differential Diagnosissupporting

confidence: 50%

Section: Differential Diagnosismentioning

confidence: 99%

Cribriform Adenocarcinoma of the Tongue and Minor Salivary Glands: A Review

Michal

Kacerovská

Kazakov

2013

Head and Neck Pathol

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“…They suggested an epithelial basal/stem/reserve cell origin for polymorphous low-grade adenocarcinoma, but since p63 also stains myoepithelial cells, myoepithelial histogenesis cannot be completely ruled out. Perez-Ordonez et al 17 reported that all polymorphous low-grade adenocarcinoma (100%) expressed 34bE12 in their series. Similarly Gnepp et al and Regezi et al 18,19 reported the expression of high molecular weight keratin in PLGA.…”

Section: Discussionmentioning

confidence: 80%

“…These tumor cells did not express the markers suggestive of myoid/smooth muscle differentiation, consistent with previous reports. 2,11,16,17 However, polymorphous low-grade adenocarcinoma expressed metallothionein, maspin, and p63, the latter two frequently and diffusely. Metallothionein, maspin, and p63 are known to be strongly expressed in simple epithelia, basal/stem cells and myoepithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…21 Indeed, expression of carcinoembryonic antigen, a hallmark of glandular differentiation, seen in most adenocarcinomas has rarely been demonstrated in polymorphous low-grade adenocarcinoma. 17,18,22 The tumor cells in polymorphous lowgrade adenocarcinoma do not express proteins associated with myoid differentiation (smooth muscle actin, smooth muscle myosin heavy chain, calponin) or glandular differentiation (carcinoembryonic antigen) but express proteins associated with basal cells such as 34bE12, p63, maspin, and metallothionein. This appears to favor basaloid/ stem/reserve cell immunophenotypic features.…”

Section: Discussionmentioning

confidence: 99%

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Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma

Prasad

Bárbácioru²,

Rawal

et al. 2008

Modern Pathology

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Distinguishing adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma of the salivary glands is important for their management. We studied the expression of several myoepithelial and basal/stem cell markers (smooth muscle actin, calponin, smooth muscle myosin heavy chain, metallothionein, maspin, and p63) by immunohistochemistry in 23 adenoid cystic carcinoma and 24 polymorphous low-grade adenocarcinoma, to identify the most useful marker or combination of markers that may help their diagnoses. The results were analyzed using hierarchical cluster analysis and v 2 test for trend. We noted diffuse expression of smooth muscle actin in 20 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (Po0.0001), calponin in 15 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (Po0.0001), smooth muscle myosin heavy chain in 15 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma (P ¼ 0.001), metallothionein in 22 adenoid cystic carcinoma vs eight polymorphous low-grade adenocarcinoma (Po0.001), maspin in 22 adenoid cystic carcinoma vs 14 polymorphous low-grade adenocarcinoma, and p63 in 21 adenoid cystic carcinoma vs 14 polymorphous low-grade adenocarcinoma. Hierarchical clustering of smooth muscle actin, calponin, smooth muscle myosin heavy chain, and metallothionein was virtually identical (jr0.0035), suggesting no significant advantage to their use in combination than individually. Diffuse smooth muscle actin expression showed the highest accuracy (91.5%) and positive predictive value (95.2%) for adenoid cystic carcinoma. Thus, diffuse expression of smooth muscle actin, calponin, smooth muscle myosin heavy chain, and metallothionein was highly predictive of adenoid cystic carcinoma, whereas maspin and p63 were frequently expressed in both tumors. In differentiating adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma, smooth muscle actin as a single ancillary test in support of the histological findings, appears to be as efficient as multiple immunohistochemical tests.

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