Polymorphous Low-Grade Adenocarcinoma of the Lacrimal Gland

Selva, Dinesh; Davis, Garry; Dodd, Tom; Rootman, Jack

doi:10.1001/archopht.122.6.915

Cited by 15 publications

(10 citation statements)

References 6 publications

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“…2009), polymorphous low‐grade adenocarcinoma (Ni et al. 1992; Selva et al. 2004), basal cell carcinoma (Khalil & Arthurs 2000) and cystadenocarcinoma (Devoto & Croxatto 2003).…”

Section: Rare Epithelial Tumoursmentioning

confidence: 99%

“…The patients were aged from 47 to 68 years at the time of diagnosis, and half the patients were disease-free after surgery and radiation, while two had local recurrences and one had lymphatic metastases during followup. Other rare malignancies reported include acinic cell carcinoma (De et al 1986;Fei et al 1991;Rosenbaum et al 1995;Jang et al 2001), myoepithelial carcinoma (Herrera 1990;Weis et al 2009), epithelial-myoepithelial carcinoma (Ostrowski et al 1994;Chan et al 2004;Wiwatwongwana et al 2009), carcinosarcoma (Ni et al 1992;Weis et al 2009), polymorphous low-grade adenocarcinoma (Ni et al 1992;Selva et al 2004), basal cell carcinoma (Khalil & Arthurs 2000) and cystadenocarcinoma (Devoto & Croxatto 2003).…”

Section: Rare Epithelial Tumoursmentioning

confidence: 99%

See 1 more Smart Citation

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

Holstein

Coupland

Briscoe

et al. 2012

Acta Ophthalmologica

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. Epithelial tumours of the lacrimal gland represent a large spectrum of lesions with similarities in clinical signs and symptoms but with different biological behaviour and prognosis. They are rare, but with aggressive malignant potential. Tumours of the lacrimal gland may present with swelling of the lacrimal gland, displacement of the eyeball, reduced eye motility and diplopia. Pain and symptoms of short duration before the first ophthalmic consultation are characteristic of malignant tumours. The histological diagnosis determines the subsequent treatment regimen and provides important clues regarding the prognosis. The purpose of this paper is to describe the various primary epithelial tumours of the lacrimal gland. In the first part of the review, the frequency, demographics, clinical presentation and diagnostic features are described. In the second part, primarily tumour‐specific histological characteristics are given. Finally, treatment modalities including surgical procedures and medical oncology as well as prognosis are discussed.

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“…2009), polymorphous low‐grade adenocarcinoma (Ni et al. 1992; Selva et al. 2004), basal cell carcinoma (Khalil & Arthurs 2000) and cystadenocarcinoma (Devoto & Croxatto 2003).…”

Section: Rare Epithelial Tumoursmentioning

confidence: 99%

Section: Rare Epithelial Tumoursmentioning

confidence: 99%

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

Holstein

Coupland

Briscoe

et al. 2012

Acta Ophthalmologica

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“…Malignant Tumor Types Not Seen in Our Series. Isolated cases of several other tumor types have been reported in the lacrimal gland, including polymorphous lowgrade adenocarcinoma, 5,40 acinic cell carcinoma, [24][25][26][27] basal cell adenocarcinoma, 54 epithelial-myoepithelial carcino-ma, 42 and cystadenocarcinoma, 46 all of which appear to be low grade, as well as primary sebaceous adenocarcinoma 5,[47][48][49][50][51][52][53] and lymphoepithelial carcinoma, 44,45 both of which are considered high grade. Since completing this review, we have seen a single case each of epithelialmyoepithelial carcinoma, acinic cell carcinoma, and myoepithelial carcinoma in the Orbit Clinic, University of British Columbia.…”

Section: Malignant Epithelial Neoplasiamentioning

confidence: 99%

“…In 2006 the AFIP monograph on lacrimal gland tumors 17 showed an expanded classification based on the 1992 WHO classification of salivary gland tumors. It is also clear that the salivary gland classification has filtered into the lacrimal gland literature, which has described many tumors analogous to their salivary gland counterparts, including ductal carcinoma, [18][19][20][21][22][23] acinic cell carcinoma, [24][25][26][27] primary squamous cell carcinoma, [28][29][30][31] mucoepidermoid carcinoma, 20,[32][33][34][35][36][37][38] oncocytic carcinoma, 39 polymorphous low-grade adenocarcinoma, 5,40 myoepithelial carcinoma, [41][42][43] lymphoepithelial carcinoma, 44,45 epithelial-myoepithelial carcinoma, 42 cystadenocarcinoma, 46 primary sebaceous adenocarcinoma, 5,[47][48][49][50][51][52][53] basal cell adenocarcinoma, 54 oncocytoma, 55,56 cystadenoma, …”

mentioning

confidence: 99%

Epithelial Lacrimal Gland Tumors

Weis

Rootman²,

Joly³

et al. 2009

Arch Ophthalmol

124

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To apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gland tumor classification scheme. Methods: A retrospective multicenter cohort study of 118 cases of epithelial neoplasia was undertaken. Main outcome measures included pathologic analysis, subtyping, and survival. Results: Of 118 cases, 17 (14%) were reclassified using the proposed expanded classification scheme based on the current World Health Organization classification of salivary gland tumors. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, of which we highlight more unusual histologic features. Three tumors were found to be unclassifiable with the updated scheme, with 2 having histologically malignant features. Deficiencies and variations in pathologic assessment were noted. Variation in the histologic findings of pleomorphic adenoma and assessment of the extent of invasion of carcinoma ex pleomorphic adenoma were highlighted. Conclusions: The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. This expanded classification system led to reclassifying 14% of cases. Currently, there are no consistent pathologic standards for processing and evaluating these lesions.

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“…PLGA is virtually exclusive of minor salivary glands of the oral cavity [1,3]; in rare occasions, it has been reported in the parotid [19] and, in even rarer occasions, in other sites such as the lung [17], skin [24], vulva and vagina [27] and lacrimal glands [22]. The purpose of the present paper is to describe three cases of tumours in the breast with morphology similar to that of PLGA of the salivary glands.…”

Section: Introductionmentioning

confidence: 97%

Polymorphous adenocarcinoma of the breast. Report of three cases

et al. 2005

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We report three cases of polymorphous adenocarcinoma (PLA) of the breast in 37-, 55- and 74-year-old women, respectively. The patients have no evidence of previous malignancy. The tumours consist of monotonous cells showing a wide spectrum of growth patterns: solid nests, trabeculae, tubules, cribriform structures, strands and fascicles reminiscent of polymorphous low-grade adenocarcinoma of salivary glands. To our knowledge, PLA has never been reported in the breast; therefore, this tumour should be added to the list of neoplastic lesions of the breasts that have the same features as those of the salivary glands.

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Polymorphous Low-Grade Adenocarcinoma of the Lacrimal Gland

Cited by 15 publications

References 6 publications

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

Epithelial Lacrimal Gland Tumors

Polymorphous adenocarcinoma of the breast. Report of three cases

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