Polymorphous low-grade adenocarcinoma: a case report

Potluri, Anitha; Prasad, Jessica; Levine, Scott M.; Bastaki, JM

doi:10.1259/dmfr/14804843

Cited by 7 publications

(17 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymorphous low-grade adenocarcinoma (PLGA) was first described in 1983 by Freedman and Lumerman, and Batsakis et al as "lobular carcinoma" and "terminal duct carcinoma" for its similarities to lobular carcinoma of the breast [6][7][8][9]. In 1984, the term "polymorphous low-grade adenocarcinoma" was suggested by Evans and Batsakis, and, subsequently, it was recognized as its own entity by the World Health Organization (WHO) in 1990 [9][10][11][12].…”

Section: Polymorphous Low-grade Adenocarcinomamentioning

confidence: 99%

“…It comprises 7-11% of all tumours in the minor salivary glands, and 19-26% of all malignancies of the minor salivary glands [9]. PLGA is not limited to minor salivary glands, but may occur in major salivary glands or from an existing pleomorphic adenoma; however, in both instances this is rare [8,9,11].…”

Section: Epidemiology Demographicsmentioning

confidence: 99%

“…PLGA exhibits variable radiographic characteristics; features are generally consistent with a slow growing, but aggressive tumour [8]. In a radiology journal, Potluri et al presented a PLGA case with significant imaging findings; plain film investigations noted loss of maxillary bone and lack of sinus floor visualization, whereas computed tomography showed irregular cortical density, thinning of cortical plates, and mass effect with maxillary bowing and bony perforations [8].…”

Section: Imaging Featuresmentioning

confidence: 99%

“…In a radiology journal, Potluri et al presented a PLGA case with significant imaging findings; plain film investigations noted loss of maxillary bone and lack of sinus floor visualization, whereas computed tomography showed irregular cortical density, thinning of cortical plates, and mass effect with maxillary bowing and bony perforations [8]. Soft tissue findings on imaging noted hypervascularity and irregular contrast enhancement [8].…”

Section: Imaging Featuresmentioning

confidence: 99%

“…They demonstrate a classic "salt and pepper" nuclear form, with optically clear chromatin [8,10,14]. PLGA tumour cells contain scant to moderate cytoplasm, which may be eosinophilic, amphophilic, and infrequently contain oncocytes and mucin cells [6,9,16].…”

Section: Histopathologymentioning

confidence: 99%

See 4 more Smart Citations

Expression of Human Tissue Kallikreins (KLKs) in Polymorphous Low Grade Adenocarcinoma (PLGA)

Cox

2014

Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Polymorphous low grade adenocarcinoma (PLGA) is the second most common malignant salivary gland tumour of the minor salivary glands. Human tissue kallikreins (KLKs) are a family of highly conserved serine proteases expressed by various tissues throughout the body. KLKs have become powerful tumour markers for the diagnosis of the cancer patient (e.g. PSA (KLK3)). The literature demonstrates a link between KLKs and salivary gland neoplasms. The purpose of this study is to determine levels of KLK mRNA in tissue samples of formalin fixed paraffin embedded polymorphous low grade adenocarcinoma (PLGA). Secondly, we wish to determine if KLK expression is limited to tumour cells alone.Nineteen cases of PLGA were reviewed . A diagnosis of PLGA was confirmed, demographic data was collected, and formalin fixed paraffin-embedded PLGA and normal salivary gland tissue samples were obtained. RNA isolation was achieved, followed by conversion to complementary DNA via reverse transcription. Synthesized DNA primers were added to target kallikrein DNA and through PCR, the quantitative level of expression of KLKs 1-15 was recorded. Samples exhibiting high and low KLK expression were selected for immunohistochemistry staining, using a standard protocol.Results from PCR data reveals statistically significant increase in the mean KLK mRNA expression for KLK1, KLK4, KLK10, KLK12 and KLK15 in PLGA tissue samples, as compared with normal salivary gland tissue (Mann Whitney U test, p<0.05).Immunohistochemistry results demonstrate tumour specific staining. Notably, all samples demonstrating relatively higher KLK mRNA expression showed equivalent or increased staining grade scores relative to the low KLK mRNA expression samples, with respect to a specific KLK.In tissue samples of polymorphous low grade adenocarcinoma there is an increase of KLK1, KLK4, KLK10, KLK12 and KLK15 mRNA relative to normal salivary gland tissue. Furthermore, the tumour cells stain positively and specifically for kallikreins.

show abstract

Section: Polymorphous Low-grade Adenocarcinomamentioning

confidence: 99%

Section: Epidemiology Demographicsmentioning

confidence: 99%

Section: Imaging Featuresmentioning

confidence: 99%

Section: Imaging Featuresmentioning

confidence: 99%

Section: Histopathologymentioning

confidence: 99%

See 3 more Smart Citations

Expression of Human Tissue Kallikreins (KLKs) in Polymorphous Low Grade Adenocarcinoma (PLGA)

Cox

2014

Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

show abstract

Establishment of a primary culture of polymorphous low grade adenocarcinoma cells

Teixeira

Montalli

Oliveira

et al. 2017

Archives of Oral Biology

View full text Add to dashboard Cite

Polymorphous Adenocarcinoma: A Rare Case Report with Unique Radiographic Appearance on CBCT

Chandra

Ahmed

Koul

et al. 2021

Case Reports in Dentistry

View full text Add to dashboard Cite

Background. Polymorphous low-grade adenocarcinoma (PLGA) is a slow growing malignant tumor of minor salivary glands and is generally of indolent nature. However, according to the most recent WHO Classification of Salivary Gland Tumors (2017), the cancer is classified as Polymorphous AdenoCarcinoma (PAC). PAC presents as a less aggressive tumor, though it could on rare occasions demonstrate distant metastasis. Case Presentation. A 47-year-old man who was referred by a private practitioner for a CBCT scan in reference to a proliferative soft-tissue growth in the hard palate. The growth was mild and tender and there was Grade III mobility in relation to all the maxillary teeth. Panoramic radiograph taken previously had revealed evidence of alveolar bone loss in relation to the maxillary teeth and was inconclusive of any other findings. The CBCT scan revealed evidence of moth-eaten appearance of maxilla with destruction of medial and lateral walls and floor of maxillary sinus. There was also evidence of involvement of right eustachian tube, ethmoidal wall, and nasopalatine canal. An intraosseous malignancy of the palate was suspected, and a total maxillectomy was performed. The tissue sample was sent for histopathological assessment wherein changes diagnostic for polymorphous low-grade adenocarcinoma of the palate were observed. Conclusion. PAC is a distinct, yet commonly occurring, minor salivary gland tumor with varied clinical and histologic appearance. This case report highlights the importance of CBCT in diagnosing the intraosseous involvement of such tumors which can help shed some light in enhancing our knowledge about the minor salivary gland malignancies like PAC.

show abstract

Polymorphous low-grade adenocarcinoma: a case report

Cited by 7 publications

References 7 publications

Expression of Human Tissue Kallikreins (KLKs) in Polymorphous Low Grade Adenocarcinoma (PLGA)

Expression of Human Tissue Kallikreins (KLKs) in Polymorphous Low Grade Adenocarcinoma (PLGA)

Establishment of a primary culture of polymorphous low grade adenocarcinoma cells

Polymorphous Adenocarcinoma: A Rare Case Report with Unique Radiographic Appearance on CBCT

Contact Info

Product

Resources

About