Polymorphonuclear Neutrophils: An Effective Antimicrobial Force

Sawyer, Daniel W.; Donowitz, Gerald R.; Mandell, Gerald L.

doi:10.1093/clinids/11.supplement_7.s1532

Cited by 95 publications

(61 citation statements)

References 111 publications

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“…Their host defense functions include the phagocytosis of invading microorganisms and cell debris, the release of proteolytic enzymes and the generation of oxygenderived reactive agents (Edwards, 1994). PMNs are potent inflammatory cells that can, when not under appropriate control, worsen disease states (Sawyer et al, 1989). Reactive oxygen metabolic products may promote the development of acute inflammatory responses and contribute to the development of tissue injury in a variety of diseases including emphysema, myocardial infarction, adult respiratory distress syndrome and rheumatoid arthritis Fantone and Ward, 1985).…”

Section: Introductionmentioning

confidence: 99%

Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal

Cadieux

Leclerc

St-Onge

et al. 2005

Journal of Cell Science

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Neutrophils, which are often the first to migrate at inflamed sites, can generate leukotriene B4 from the 5-lipoxygenase pathway and prostaglandin E2 through the inducible cyclooxygenase-2 pathway. Adenosine, an endogenous autacoid with several anti-inflammatory properties, blocks the synthesis of leukotriene B4 while it potentiates the cyclooxygenase-2 pathway in fMLP-treated neutrophils, following activation of the A2A receptor. Using the murine air pouch model of inflammation, we observed that inflammatory leukocytes from mice lacking the A2A receptor have less cyclooxygenase-2 induction than wild-type animals. In human leukocytes, A2A receptor activation specifically elicited potentiation of cyclooxygenase-2 in neutrophils, but not in monocytes. Signal transduction studies indicated that the cAMP, ERK1/2, PI-3K and p38K intracellular pathways are implicated both in the direct upregulation of cyclooxygenase-2 and in its potentiation. Together, these results indicate that neutrophils are particularly important mediators of adenosine's effects. Given the uncontrolled inflammatory phenotype observed in knockout mice and in view of the potent inhibitory actions of prostaglandin E2 on inflammatory cells, an increased cyclooxygenase-2 expression resulting from A2A receptor activation, observed particularly in neutrophils, may take part in an early modulatory mechanism promoting anti-inflammatory activities of adenosine.

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Section: Introductionmentioning

confidence: 99%

Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal

Cadieux

Leclerc

St-Onge

et al. 2005

Journal of Cell Science

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“…PMNs, the predominant circulating phagocytes, are the first to arrive at sites of infection and are critical to the host's defense against bacterial infection [13]. Neutrophils also play a role in vascular injury during acute inflammatory responses, especially in the lung due to the rich network of capillaries and constant exposure to foreign antigens [14].…”

Section: Introductionmentioning

confidence: 99%

Leukocyte subsets and neutrophil function after short-term spaceflight

Stowe

Sams

Mehta³

et al. 1999

Journal of Leukocyte Biology

137

102

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Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil function. At landing, a 1.5-fold increase in neutrophils was observed compared with preflight values; lymphocytes were slightly decreased, whereas the results were variable for monocytes. No significant changes were observed in plasma levels of immunoglobulins, cortisol, or adrenocorticotropic hormone. In contrast, urinary epinephrine, norepinephrine, and cortisol were significantly elevated at landing. Band neutrophils were observed in 9 of 16 astronauts. Neutrophil chemotactic assays showed a 10-fold decrease in the optimal dose response after landing. Neutrophil adhesion to endothelial cells was increased both before and after spaceflight. At landing, the expression of MAC-1 was significantly decreased while L-selectin was significantly increased. These functional alterations may be of clinical significance on long-duration space missions. J. Leukoc. Biol. 65: 179-186; 1999.

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“…ticles to the cell surface of granulocytes, ingestion (phagocytosis) and intracellular killing by oxygen-dependent (oxidative burst) and oxygen-independent mechanisms [9].…”

Section: Looking For the Immunological "Time Window" For The Surgicalmentioning

confidence: 99%

Looking for the immunological “time window” for the surgical intervention in patients with polytrauma

Marks¹,

Gołąbek-Dropiewska²,

Bryl³

et al. 2013

cejoi

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Polymorphonuclear Neutrophils: An Effective Antimicrobial Force

Cited by 95 publications

References 111 publications

Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal

Potentiation of neutrophil cyclooxygenase-2 by adenosine: an early anti-inflammatory signal

Leukocyte subsets and neutrophil function after short-term spaceflight

Looking for the immunological “time window” for the surgical intervention in patients with polytrauma

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