Polymorphisms of the β1-adrenergic receptor predict exercise capacity in heart failure

Wagoner, Lynne E.; Craft, L.; Zengel, Paul W.; McGuire, Nancy; Rathz, Deborah A.; Dorn, Gerald W.; Liggett, Stephen B.

doi:10.1016/s0002-8703(02)80018-7

Cited by 30 publications

(53 citation statements)

References 23 publications

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“…3 Similarly, in human atrial myocardium, noradrenaline (norepinephrine) generates both greater inotropic and cyclic AMP responses via the 389R variant compared to the 389G variant. 2 Our recruited population consisted mainly of males, as did the study population reported by Wagoner et al 5 In our patients, this reflects the sex ratio (4:1) among patients transplanted on the Papworth Hospital programme itself. Our results confirm the Wagoner study, although the differences between 389R and 389G homozygotes in our study were somewhat larger than they reported.…”

Section: Discussionmentioning

confidence: 50%

“…Our results confirm the Wagoner study, although the differences between 389R and 389G homozygotes in our study were somewhat larger than they reported. 5 This may reflect the lower LVEF seen in our subjects (( 20% v . 25% in the Wagoner cohort) and presumably more diseased myocardial tissue.…”

Section: Discussionmentioning

confidence: 79%

“…However, unlike our study, Wagoner and et al reported that the 49S.G polymorphism also affected exercise performance. 5 Since we did not power our study to address this rarer polymorphism, our finding with 49S.G may represent a false negative. A 70 year old woman presented to the emergency department with dyspnoea and fever of a few weeks duration.…”

Section: Discussionmentioning

confidence: 92%

“…Significance was taken as p , 0.05. Based on previous differences in VO 2 reported between GG and RR (14.5-17.7 ml/kg/min), 5 we estimated our sample to have at least 80% power to detect a similar difference.…”

Section: Methodsmentioning

confidence: 99%

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Confirmation of a role for the 389R>G -1 adrenoceptor polymorphism on exercise capacity in heart failure

Sandilands

2005

Heart

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

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Confirmation of a role for the 389R>G -1 adrenoceptor polymorphism on exercise capacity in heart failure

Sandilands

2005

Heart

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“…The Arg389Gly variation (rs1801253) in the β 1 AR gene ( ADRB1 ) influences exercise capacity phenotypes such as peak oxygen uptake in patients with cardiac disease, yet the results are so far contradictory 1 2. The Gly16Arg (rs1042713) polymorphism in the human β 2 AR gene ( ADRB2 ) is associated with the metabolic syndrome3 and with cardiovascular phenotypes during exercise in healthy non-athletes4 and patients with cardiac disease 5.…”

mentioning

confidence: 99%

Trp64Arg polymorphism inADRB3gene is associated with elite endurance performance: Table 1

Santiago

Ruiz

Buxens³

et al. 2009

Br J Sports Med

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In this study, allele and genotype frequencies of the ADRB1 Arg389Gly (rs1801253), ADRB2 Gly16Arg (rs1042713) and Gln27Glu (rs1042714), and ADRB3 Trp64Arg (rs4994) variations were compared in the following three groups of Spanish (Caucasian) men: (1) world-class endurance athletes (E; runners and cyclists, n=100), (2) elite power athletes (P; sprinters, jumpers and throwers, n=53) and (3) non-athletic controls (C; n=100). No significant differences were observed in genotype and allele distributions among the study groups except for the ADRB3 Trp64Arg polymorphism in E versus C (27% vs 8% of carriers of the Arg allele in E and C, p<0.001; frequency of the minor Arg (C) allele of 14% vs 4% in E and C, p=0.001). Heterozygosity for the ADRB3 Trp64Arg polymorphism seems to be associated with elite endurance performance, while other variants of the β-adrenergic receptors' genes do not seem to significantly influence top-level sports performance, at least in athletes of Spanish origin.

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Adrenergic Polymorphisms and Survival in African Americans With Heart Failure: Results From A-HeFT

Johnson

Hanley-Yanez

Yancy

et al. 2019

Journal of Cardiac Failure

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Background: Polymorphisms in adrenergic signaling affect the molecular function of adrenergic receptors and related proteins. The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity. Their combined effect within black cohorts remains unknown. Methods and Results:We analyzed subjects from the African American Heart Failure Trial (A-HeFT) by assessing event-free survival, quality of life, and gene coinheritance. Significant coinheritance effects on survival included GRK5 Leu41 among subjects coinheriting GNB3 825 C alleles (n = 166, 90.4% vs 69.0%, p < 0.001). By contrast, the impact of ADRB1 Arg389Arg genotype was magnified among subjects with GNB3 825 TT genotype (n = 181, 66.3% vs 85.7%, p = 0.002). The lack of the α2c deletion (i.e., insertion) led to a greater impact of the ARG389Arg genotype (n = 289, 76.4% vs86.1%, p = 0.007). Conclusions:Polymorphisms in adrenergic signaling affects outcomes in black subjects with heart failure. Coinheritance patterns in genetic variation may help determine heart failure survival.

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Polymorphisms of the β1-adrenergic receptor predict exercise capacity in heart failure

Cited by 30 publications

References 23 publications

Confirmation of a role for the 389R>G -1 adrenoceptor polymorphism on exercise capacity in heart failure

Confirmation of a role for the 389R>G -1 adrenoceptor polymorphism on exercise capacity in heart failure

Trp64Arg polymorphism inADRB3gene is associated with elite endurance performance: Table 1

Adrenergic Polymorphisms and Survival in African Americans With Heart Failure: Results From A-HeFT

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