Polymorphisms of the lipoprotein lipase gene are associated with atherosclerotic cerebral infarction in the Chinese

Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes

“…A study carried out by Shimo-Nakashumi et al [9] demonstrated the association of HindIII polymorphism with atherothrombotic cerebral infarction. However, a study carried out by Xu et al [23] in a Chinese population could not establish an association between HindIII polymorphism of LPL gene with atherosclerotic cerebral infarction. Chen et al [24] reported a significant correlation between carotid artery atherosclerosis and Hind III polymorphism in White male subjects.…”

The association of lipoprotein lipase PvuII polymorphism and niacin intake in the prevalence of metabolic syndrome: a KMSRI-Seoul study

“…In previous studies on the correlation between LPL PvuII polymorphism and lipid profiles, subjects with the P2P2 genotype, e.g., patients with cerebral infarction and Turks with coronary artery disease had higher TG levels and lower HDLc levels (Xu et al 2008;Duman et al 2004). Our subjects with the P2P2 genotype showed a significantly low HDLc level; a high TG level was observed only in the subjects with the P2P2 genotype in the non-MetSyn group.…”

Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

“…It is possible that the effect size of the rs328-G allele may be too small for underlying ischemic CVD, but its combination with other factors increased risk of developing the disease. Xu et al [7] excluded stroke patients with diabetes in their study and found that the rs328-G allele was less frequent in patients with ischemic stroke (7.5%) than in control subjects (19.1%). Our study demonstrated that the rs328-G allele was more frequent in stroke patients with a history of diabetes (12.9%) than those without a history of type 2 diabetes (5.7%), suggesting that the inconsistent results across independent studies may partially be attributable to the stratification of study samples.…”

“…The rs328 minor allele G (rs328-G) was found to be more frequent in patients with ischemic stroke than in control subjects in an African American sample consisting of 197 patients with subclinical infarction, 218 with incident ischemic stroke, and 964 control subjects [2], and in a Chinese sample of 246 patients with ischemic stroke and 336 healthy controls [3]. However, opposite results have been shown in a Finnish sample consisting of 119 patients with ischemic stroke and 133 controls [4]; a Japanese sample of 71 patients with atherothrombotic infarction, 30 with cardioembolic infarction patients, 76 with lacunar infarction, and 177 healthy controls [5]; a Chinese sample of 96 patients with ischemic stroke, 64 with hemorrhagic stroke, and 117 controls [6], as well as 185 patients with ischemic stroke and 186 controls [7]; and a Swedish sample of 928 patients with ischemic stroke and 602 controls [8]. There have been at least two studies failing to show the rs328 association with ischemic stroke [9,10].…”