Polymorphisms of the interleukin 6 gene and additional gene–gene interaction contribute to cervical cancer susceptibility in Eastern Chinese women

Pu, Xiaowen; Gu, Zhuowei; Wang, Xipeng

doi:10.1007/s00404-016-4175-x

Cited by 24 publications

(19 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are three articles about the association between rs2069837 and cancer risk, and their results consistently showed that the rs2069837-AA genotype was a protective factor for cervical cancer and hepatocellular carcinoma, one study found that rs2069837 were related to the IL6 expression level in cervical tissues. [36–38]. In our study the results were not statistically significant, further studies with lager sample size are needed to be conducted to explore the inconsistent result.…”

Section: Discussioncontrasting

confidence: 59%

Multiple functional SNPs in differentially expressed genes modify risk and survival of non-small cell lung cancer in chinese female non-smokers

Fang

Yin

et al. 2017

Oncotarget

View full text Add to dashboard Cite

DNA genotype can affect gene expression, and gene expression can influence the onset and progression of diseases. Here we conducted a comprehensive study, we integrated analysis of gene expression profile and single nucleotide polymorphism (SNP) microarray data in order to scan out the critical genetic changes that participate in the onset and development of non-small cell lung cancer (NSCLC). Gene expression profile datasets were downloaded from the GEO database. Firstly, differentially expressed genes (DEGs) between NSCLC samples and adjacent normal samples were identified. Next, by STRING database, protein-protein interaction (PPI) network was constructed. At the same time, hub genes in PPI network were identified. Then, some functional SNPs in hub genes that may affect gene expression have been annotated. Finally, we carried a study to explore the relationship between functional SNPs and NSCLC risk and overall survival in Chinese female non-smokers. A total of 488 DEGs were identified in our study. There are 29 proteins with a higher degree of connectivity in the PPI network, including FOS, IL6 and MMP9. By using database annotation, we got 8 candidate functional SNPs that may affect the expression level of hub proteins. In the case-control study, we found that rs4754-T allele, rs959173-C allele and rs2239144-G allele were the protective allele of NSCLC risk. In dominant model, rs4754-CT+TT genotype were associated with a shorter survival time. In general, our study provides a novel research direction in the field of multi-omic data integration, and helps us find some critical genetic changes in disease.

show abstract

Section: Discussioncontrasting

confidence: 59%

Multiple functional SNPs in differentially expressed genes modify risk and survival of non-small cell lung cancer in chinese female non-smokers

Fang

Yin

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…However, Grimm et al failed to detect relationship between IL-6 -174G>C polymorphism and the risk for cervical cancer [ 27 ]. A recent study by Pu et al [ 26 ] found that cervical cancer risks were significantly higher in carriers of C allele of rs1800795 polymorphism than those with GG genotype. By now, only one meta-analysis by Liu et al [ 30 ] was conducted to explore the association between IL-6 -174G>C and cervical cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility

Duan

Chen²,

Shi

et al. 2018

Bioscience Reports

View full text Add to dashboard Cite

Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive a more precise estimation of the relationship, we performed this meta-analysis updated to June 2018. A total of seven original publications were identified covering IL-6 -174G>C (rs1800795) polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. Statistically significant relationship was observed between IL-6 -174G>C polymorphism and cervical cancer risk (OR = 0.61, 95% CI: 0.40–0.94 for GG vs. CC, and OR = 0.77, 95% CI: 0.64–0.93 for G vs. C). Moreover, the significant association was found among Asians (OR = 0.46, 95% CI: 0.29–0.75 for GG vs. CC, and OR = 0.70, 95% CI: 0.57–0.89 for G vs. C); hospital-based subgroup (OR = 0.53, 95% CI: 0.38–0.72 for GG vs. CC, and OR = 0.73, 95% CI: 0.61–0.87 for G vs. C); and Hardy–Weinberg equilibrium ≤0.05 (OR = 0.56, 95% CI: 0.37–0.86 for GG vs. GC, and OR = 0.66, 95% CI: 0.47–0.93 for G vs. C). This meta-analysis showed the evidence that the IL-6 -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case–control studies are needed to confirm these results.

show abstract

“…Some epidemiological studies suggested that IL-12B rs3212227 and IL-6 rs1800795 polymorphisms are associated with an increased risk of cervical cancer. However, two recent meta-analyses were performed to evaluate IL-12B rs3212227 and IL-6 rs1800795 polymorphisms with cervical cancer risk and their results indicated that no significant association was found among all ethnicities (Chang et al, 2015;Liu et al, 2017;Pu et al, 2016;Zheng et al, 2017). Therefore, controversy and inconformity still remained about IL-12B rs3212227 and IL-6 rs1800795 polymorphisms and most of studies recruited a limited sample capacity, which is insufficient to get a firm conclusion about the associations of these polymorphisms with development of cervical cancer.…”

Section: Association Of Il-12b Rs3212227 and Il-6 Rs1800795mentioning

confidence: 99%

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

Karimi-Zarchi¹,

Abbasi²,

Javaheri³

et al. 2020

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Cervical cancer is the second most commonly diagnosed malignancy and third leading cause of cancer-related mortality among women in less developed countries (Karimi Zarchi et al., 2010; Mousavi et al., 2008). According to GLOBOCAN, cervical cancer accounts for 528,000 new cases and 266,000 deaths worldwide in 2012 (Parkin et al., 2005). Although, it has been widely accepted for several decades that Human papillomavirus (HPV) is the main risk factor for development of cervical cancer (Behtash et al., 2009; Farbod et al., 2019; Ghaemmaghami et al., 2008), HPV infections have developed to persistent infection in only a very few cases and it is sufficient to induce cervical cancer in an even smaller proportion

show abstract

Polymorphisms of the interleukin 6 gene and additional gene–gene interaction contribute to cervical cancer susceptibility in Eastern Chinese women

Abstract: Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk.

Cited by 24 publications

References 22 publications

Multiple functional SNPs in differentially expressed genes modify risk and survival of non-small cell lung cancer in chinese female non-smokers

Multiple functional SNPs in differentially expressed genes modify risk and survival of non-small cell lung cancer in chinese female non-smokers

Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About

Polymorphisms of the interleukin 6 gene and additional gene–gene interaction contribute to cervical cancer susceptibility in Eastern Chinese women

Abstract: Minor allele of rs1800795 and rs2069837 and its interaction were associated with increased cervical cancer risk.

Cited by 24 publications

References 22 publications

Multiple functional SNPs in differentially expressed genes modify risk and survival of non-small cell lung cancer in chinese female non-smokers

Multiple functional SNPs in differentially expressed genes modify risk and survival of non-small cell lung cancer in chinese female non-smokers

Association of IL-6 -174G&gt;C (rs1800795) polymorphism with cervical cancer susceptibility

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About

Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility