Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

Abstract

Cervical cancer is the second most commonly diagnosed malignancy and third leading cause of cancer-related mortality among women in less developed countries (Karimi Zarchi et al., 2010; Mousavi et al., 2008). According to GLOBOCAN, cervical cancer accounts for 528,000 new cases and 266,000 deaths worldwide in 2012 (Parkin et al., 2005). Although, it has been widely accepted for several decades that Human papillomavirus (HPV) is the main risk factor for development of cervical cancer (Behtash et al., 2009; Farbod et al., 2019; Ghaemmaghami et al., 2008), HPV infections have developed to persistent infection in only a very few cases and it is sufficient to induce cervical cancer in an even smaller proportion

Polymorphisms of the interleukin‐6 (IL‐6) gene contribute to cervical cancer susceptibility in Bangladeshi women: A case‐control study

“… 18 This finding is further strengthened by multiple meta‐analysis reports which demonstrated a positive association between the G > C mutation of rs1800795 with cervical cancer. 14 , 25 , 42 , 43 Moreover, a recent meta‐analysis by Harun‐Or‐Roshid et al found that the presence of C allele increases the risk of cervical cancer in women of Asian and African ancestry. 15 …”

“…In a different meta‐analysis, the C allele of rs1800795 polymorphism was similarly linked to an increased risk of cervical cancer in women of Han Chinese, Brazilian, Indian, and Caucasian ethnicities 14 . However, negative association of this polymorphism with cervical cancer has also been reported in Caucasian and Brazilian women 25,28 …”

“…A recent meta‐analysis found that rs1800795 polymorphism was significantly associated with an increased risk of cervical cancer in Asian (Korean, Chinese, and Indian) women. 25 Several studies have reported that the presence of at least one C allele in the IL‐6 promoter region (−174G>C) increased the risk of cervical cancer in Eastern Chinese 26 and Indian populations. 27 In a different meta‐analysis, the C allele of rs1800795 polymorphism was similarly linked to an increased risk of cervical cancer in women of Han Chinese, Brazilian, Indian, and Caucasian ethnicities.…”

“… 14 However, negative association of this polymorphism with cervical cancer has also been reported in Caucasian and Brazilian women. 25 , 28 …”

“…A recent meta‐analysis found that rs1800795 polymorphism was significantly associated with an increased risk of cervical cancer in Asian (Korean, Chinese, and Indian) women 25 . Several studies have reported that the presence of at least one C allele in the IL‐6 promoter region (−174G>C) increased the risk of cervical cancer in Eastern Chinese 26 and Indian populations 27 .…”