Polymorphisms of the folate metabolizing enzymes: Association with SLE susceptibility and in silico analysis

Association Analysis of Methylenetetrahydrofolate Reductase Common Gene Polymorphisms with Breast Cancer Risk in an Iranian Population: A Case-Control Study and a Stratified Analysis

“…A study with bioinformatics analysis revealed that both C677T and A1298C genetic variations made significant changes in the secondary structure of MTHFR-mRNA. Moreover, a structural examination of the A1298C polymorphism showed a significant impact on the function of MTHFR (Salimi et al, 2017).…”

Common gene polymorphism in ATP‐binding cassette transporter A1 and coronary artery disease: A genetic association study and a structural analysis

“…There are several reported polymorphisms in ABCA1 gene such a R230C, R1587K, and V825I which one of them is R219K polymorphism. Measurement of the molecular effect of polymorphisms by bioinformatics software could be an appropriate tool for evaluation of the effects of SNPs on structure and function of the interested protein 56‐60 . In the current project, we have evaluated the impacts of p.R219K polymorphisms on the protein structure of ABCA1.…”

Association of ApaI and TaqI polymorphisms in VDR Gene with Breast Cancer

“…But computational methods using bioinformatics tools can be a useful way for molecular analysis especially to evaluate the effects of genetic polymorphisms (Karimian et al, 2015;Noureddini et al, 2018;Tameh et al, 2018;Mobasseri et al, 2019;Karimian et al, 2020). In silico analysis is a useful tool to evaluate the effects of SNPs on protein and mRNA structure (Salimi et al, 2017;Bafrani et al, 2019). Therefore, this tool would be an appropriate approach to study the effects of TaqI and ApaI on the VDR gene function.…”