Common gene polymorphism in ATP‐binding cassette transporter A1 and coronary artery disease: A genetic association study and a structural analysis

Karimian, Mohammad; Momeni, Ali; Farmohammadi, Amir; Behjati, Mohaddeseh; Jafari, Mohammadali; Raygan, Fariba

doi:10.1002/jcb.29606

Cited by 24 publications

(9 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even the same ABCA1 gene SNPs have similar or opposite effects [42,43] . Therefore, genetic polymorphisms in this gene may alter the susceptibility or the improvement of CHD.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Four Different Single Nucleotide Polymorphisms on Coronary Heart Disease in a Han Chinese Population in Xinjiang Region

Abudureyimu

Abulaiti

Xing

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: In this current work we aimed to find the effect of four different single Nucleotide Polymorphisms(SNPs) rs1122608(SMARCA4)，rs2230806(ABCA1), rs12563308（ANGPTL3）,and rs662799（APOA5 ) on coronary heart disease(CHD) in a Han Chinese population in Xinjiang region of China. Methods: This study involved 914 subjects with 493 CHD patients and 421 healthy controls. The genotype distribution of analyzed and their relations with CHD risk factors were assessed.Results: No statistical differences were found in genotype and allele distributions of above SNPs between CHD and healthy controls (P>0.05). Serum level of high-density lipoprotein cholesterol (HDL-C) was higher in in TT genotype of rs1122608 when compared with GT and GG genotypes (P< 0.01) in CHD patients ; serum triglyceride(TG) level was higher in rs662799 GG genotype than GA and AA genotypes(P <0.00); AA of rs662799 was associated with higher HDL-C level compared with other two genotypes (P < 0.01) ; rs12563308 and rs223086 were not associated with any serum lipid traits (P > 0.05 for all). Logistic regression analysis showed that the SNPs examined were not related to CHD (p > 0.05). Also no association was found between four SNPs with the angiographic severity of CHD patients (p > 0.05). Conclusions: APOA5 rs662799 GG allele is associated with elevated triglyceride and might act as a risk factor for CHD; SMARCA4 rs1122608 TT allele and APOA5 rs662799 AA allele are associated with elevated high-density lipoprotein cholesterol levels, and might play a protective role in the development of CHD.

show abstract

“…Even the same ABCA1 gene SNPs have similar or opposite effects [42,43] . Therefore, genetic polymorphisms in this gene may alter the susceptibility or the improvement of CHD.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Four Different Single Nucleotide Polymorphisms on Coronary Heart Disease in a Han Chinese Population in Xinjiang Region

Abudureyimu

Abulaiti

Xing

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The potential impact of MTHFR enzyme activity on DNA methylation, synthesis, and repair make it a possible candidate in cancer-predisposing (Campbell et al, 2002). The SNP's effects on the molecular aspects of a gene were dependent on its gene location (Karimian et al,(2020); Mobasseri et al, 2019). Evaluation of these effects by in vitro and in vivo methods is very time and cost consuming (Zamani-Badi et al, 2018;Bafrani et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Methylenetetrahydrofolate Reductase Common Gene Polymorphisms with Breast Cancer Risk in an Iranian Population: A Case-Control Study and a Stratified Analysis

Karimian

Rezazadeh

Khamehchian

2020

Asian Pac J Cancer Prev

Self Cite

View full text Add to dashboard Cite

breast diseases, history of breast cancer in the first-degree family, early menstruation, late menopause, nulliparity, and higher socioeconomic status (Kamińska et al., 2015). Genetic factors also play an important role in tumor formation and progression. For example, aneusomy of chromosome 17, deletion of loci at 16q, 11q, 6q, and 3p and polymorphisms in genes involved in the key cellular pathways can be the main risk factors for breast cancer (Newsham, 1998). One of the important cellular pathways is the folate metabolism cycle which includes many genes such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR). The role of the MTHFR enzyme is to convert 5,10-methylenetetrahydrofolate (5,10-MTHF) to

show abstract

“…HDLC, LDLC, TG and TC), and the risk of common human diseases (e.g. CVD 23 , 73 , diabetes 74 and obesity 49 ) has been extensively investigated. Thus, this polymorphism has been observed as a promising prognostic and predictive biomarker of these diseases for susceptible individuals 23 .…”

Section: Discussionmentioning

confidence: 99%

Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis

Shi

Tian

Zhao

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Conflicting evidence was found about the relationship between lipid profiles and R219K polymorphism in adenosine triphosphate-binding cassette exporter A1 (ABCA1) gene. In this study, four meta-analyses were conducted to assess the effect of R219K on lipid levels, including high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol, total cholesterol, and triglycerides (TG). A total of 125 samples of 87 studies (about 60,262 subjects) were included. The effect of each study was expressed using the standard mean difference (SMD) and 95% confidence interval (95% CI) and pooled by meta-analysis in the random-effects model. Subgroup and meta-regression analyses were conducted to explore potential heterogeneity sources. The overall pooled effect showed the following results. (1) The R219K was significantly associated with HDLC level (SMD = − 0.25 mmol/L, 95%CI − 0.32 to − 0.18, z = − 6.96, P < 0.01, recessive genetic model). People with different genotypes had significantly different HDLC levels under the recessive, codominant and dominant genetic models (all Ps < 0.01). (2) A weak and indeterminate relationship between R219K and TG level was observed (SMD = 0.18 mmol/L, 95%CI 0.06–0.30, z = 3.01, P < 0.01, recessive genetic model). These findings suggested that R219K was associated with HDLC and TG levels, which might implicate a promising clinical application for lipid-related disorders, though the influences of race, health status, BMI, and other heterogeneity sources should be considered when interpreting current findings. The protocol was registered at PROSPERO (registration number: CRD42021231178).

show abstract

Common gene polymorphism in ATP‐binding cassette transporter A1 and coronary artery disease: A genetic association study and a structural analysis

Abstract: ATP-binding cassette transporter A1 (ABCA1) has a crucial role in removing intracellular cholesterol and plays a protective role against atherosclerosis.

Cited by 24 publications

References 46 publications

The Effect of Four Different Single Nucleotide Polymorphisms on Coronary Heart Disease in a Han Chinese Population in Xinjiang Region

The Effect of Four Different Single Nucleotide Polymorphisms on Coronary Heart Disease in a Han Chinese Population in Xinjiang Region

Association Analysis of Methylenetetrahydrofolate Reductase Common Gene Polymorphisms with Breast Cancer Risk in an Iranian Population: A Case-Control Study and a Stratified Analysis

Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis

Contact Info

Product

Resources

About