Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: A case–control study

Liu, Zhensheng; Luo, Wei; Wang, Li E.; Sturgis, Erich M.; Wei, Qingyi

doi:10.1016/j.canlet.2008.03.034

Cited by 52 publications

(36 citation statements)

References 25 publications

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“…Genetic and epigenetic factors are associated with a susceptibility to cancer development at a young age (4,37). Alternatively, genetic and epigenetics factors may play a stronger role than HPV-16/18 infection in the development of HNSSC at an early age (38)(39)(40)(41)(42). In the current study, we did not observe differences in survival associated with age, in agreement with previous studies (4,37).…”

Section: Discussionsupporting

confidence: 92%

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

et al. 2012

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Abstract.Recently, high-risk human papillomavirus (HPV) has emerged as a possible agent associated with head and neck squamous cell carcinoma (HNSCC) in younger patients. Therefore, the purpose of the present study was to assess the effect of age on the distribution of HPV-16/18 in HNSCC, together with the impact of the virus on patient prognosis. A longitudinal prospective study was used adjusted for age, gender, TNM staging, smoking status and alcohol consumption. HPV was detected by PCR with consensus primers. Results showed there was no difference in the frequency of HPV-16/18 positivity when younger patients were compared to the older patients. No association was found among highrisk HPV positivity, gender, smoking habit and anatomical site. High-risk HPV was associated with advanced TNM in bivariate analyses; however, it did not impact on survival. Only TNM staging was associated with risk of mortality. Our study supports the theory that age does not affect the presence of HPV-16/18 in HNSCC and has no impact on patient prognosis. The incidence of HNSCC among patients under the age of 45 years is reportedly on the increase worldwide. The factors associated with HNSCC in younger adults are not well established. Findings of this study indicate that HPV-16/18 may not play a role in HNSCC patients under the age of 45 years.

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Section: Discussionsupporting

confidence: 92%

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

et al. 2012

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“…Previously, contradictory conclusions have been made regarding the association of the -579 G>T polymorphism with various cancers. Previous studies have revealed that -579 G>T polymorphisms have no association with esophageal cancer and head and neck squamous cell carcinoma (25,35), but that they may be an indication of gastric cancer (22).…”

Section: Discussionmentioning

confidence: 97%

The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer

Liu

Jiao

Guan

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the association of the -579 G>T polymorphism in the DNMT3B promoter with susceptibility to lung cancer. A total of 174 lung cancer patients and 135 healthy controls from the northern part of China were enrolled, and were matched for gender and age. All subjects were genotyped by polymerase chain reaction-restriction-fragment length polymorphism analysis and confirmed by DNA sequencing. Stratification analyses were used to study the subgroups of subjects by age and gender, and evaluate the association between the -579 G>T polymorphism and the genetic susceptibility to lung cancer. The results revealed that individuals with the DNMT3B -579 GT genotype had a significantly decreased risk of lung cancer [odds ratio (OR), 0.517; 95% confidence interval (CI), 0.273-0.981] compared with those with a -579 TT genotype in the studied population. However, the deviation was significant (OR, 0.138, 95% CI, 0.034-0.549) between the risk of lung cancer and the GT and GG genotype, when the smoking factor was considered. The data from this study indicate that the DNMT3B genetic polymorphism varies among various races, ethnic groups and geographical areas. The DNMT3B -579 G>T polymorphism may contribute to the genetic susceptibility to lung cancer.

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“…Research efforts have focused on hypermethylation by the 3 active DNMTs: DNMT1, DNMT3A, and DNMT3B. Common variants of these genes are associated with susceptibility to several cancers, including breast cancer (Kanai et al, 2003;Montgomery et al, 2004;Cebrian et al, 2006;Kelemen et al, 2008;Liu et al, 2008;Xiang et al, 2010;Fan et al, 2010;Hu et al, 2010), as altered enzyme activities can disrupt the methylation balance in cells. At present, only 2 studies have assessed the associations between DNMT polymorphisms and breast cancer in Chinese populations, and the results are controversial (Ye et al, 2010;Xiang et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Montgomery et al (2004) have demonstrated that rs2424913 in DNMT3B is significantly associated with breast cancer risk in a British population; compared with the TT genotype, the CC and CT genotypes appear to increase breast cancer risk significantly (OR = 1.51; 95%CI = 1.01-2.25). Shen et al (2002) and Liu et al (2008) have reported that DNMT3B genotypes with the T allele are associated with increased risk for squamous cell carcinoma of the head and neck and lung cancer in Western populations. Another DNMT3B SNP, rs6087990, significantly affects promoter activity and is associated with a 50% reduction in lung cancer risk in a Korean population (Lee et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China

Sun¹,

Yang²,

Xu³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide polymorphisms (SNPs) in DNMT1, DNMT3A, DNMT3B, DNMT3L, and DNMT2 with breast cancer among Han Chinese women from South China. Sixteen SNPs (rs2114724, rs2228611, rs2228612, rs8101866, and rs16999593 in DNMT1; rs13420827, rs11887120, rs13428812, rs1550117, rs11695471, and rs6733301 in DNMT3A; rs2424908, rs2424913, and rs6087990 in DNMT3B; rs113593938 in DNMT3L, and rs11254413 in DNMT2) in 408 women with breast cancer and 469 controls were genotyped using a MassARRAY matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry platform. Two SNPs, Polymorphisms of DNMT1 and DNMT3B and breast cancer risk rs16999593 in DNMT1 and rs2424908 in DNMT3B, were significantly associated with breast cancer risk. The heterozygous genotype CT of rs16999593 was associated with increased breast cancer risk [odds ratio (OR) = 1.60; 95% confidence interval (95%CI) = 1.20-2.14; P = 0.0052], whereas rs2424908 was associated with decreased risk (OR = 0.62; 95%CI = 0.46-0.84; P = 0.0061). Other DNMT polymorphisms showed no significant associations with breast cancer risk in the study population. Haplotype CGTC of rs2114724, rs2228611, rs8101866, and rs16999593 in DNMT1 differed significantly as a risk factor between the case and control groups (OR = 1.51; 95%CI = 1.18-1.93; P = 0.0012). The heterozygous genotypes of rs16999593 in DNMT1 and rs2424908 in DNMT3B were strongly associated with breast cancer risk.

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Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: A case–control study

Cited by 52 publications

References 25 publications

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer

Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China

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