Polymorphisms of IL-1B, IL-1RN, IL-2, IL-4, IL-6, IL-10, and IFN-γ genes in the Korean population

Pyo, Chul‐Woo; Hur, Soo-Young; Kim, Yang-Kyum; Choi, Hee-Baeg; Hong, Yong-Kil; Kim, Dong-Wook; Kim, Chun-Choo; Kim, Hack-Ki; Kim, Tai‐Gyu

doi:10.1016/s0198-8859(03)00173-3

Cited by 54 publications

(20 citation statements)

References 69 publications

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“…Similar findings have also been demonstrated in Africans and the remaining Eastern Asian populations [9,10,11–13,15,16,21–23] (Table 3). It is also interesting to note the absence of the homozygous C genotype among the Chinese, Korean and African populations [9,16,19,22,23]. …”

Section: Discussionsupporting

confidence: 85%

Ethnic Variation in Interleukin-6 –174 (G/C) Polymorphism in the Malaysian Population

Gan

Subramaniam

Lian

et al. 2013

Balkan Journal of Medical Genetics

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Interleukin-6 (IL-6) is one of the cytokines that has been well studied and implicated in many diseases including cancers. The frequency of the IL-6 –174 (G/C) polymorphism had been proven to differ in various populations. Malaysia is a country with three major ethnic populations, Malays, Chinese and Indians. In this study, we proposed to determine the G or C allele frequency of the IL-6 –174 polymorphism in these three populations. A total of 348 blood samples were available for analysis. The median age for the subjects was 31 years. There were a total of 245 males and 103 females. A total of 86 Malays (25.0%), 122 Chinese (33.0%) and 140 Indians (40.0%) were genotyped. The result showed a significant difference in the G or C allele frequency of the –174 polymorphism. The total frequencies for the G and C alleles were 91.0 and 9.0%, respectively. In the Malays, the allele frequency of the C allele was 4.0% compared with 19.0% in the Indians. The C allele was not detected in the Chinese population. This finding is the first reported on the Malaysian population and may be important in determining risk of diseases associated with the IL-6 polymorphism in these three populations.

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Section: Discussionsupporting

confidence: 85%

Ethnic Variation in Interleukin-6 –174 (G/C) Polymorphism in the Malaysian Population

Gan

Subramaniam

Lian

et al. 2013

Balkan Journal of Medical Genetics

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“…The frequency of the IL‐1B ‐511 T/T genotype in our control group (24%) was compatible with those from Asia 12,27,32 . Although the number of our control group was relatively small, the allele frequencies of the IL‐1 gene were very similar to the results from a large population‐based study in Korea 33 . The Caucasian population may have a much lower frequency of IL‐1B ‐511 T/T than the Asian population, for instance, it is reported to be 13% in Scottish and Polish populations 9 and 14.2% in the Portuguese population 10 .…”

Section: Discussionsupporting

confidence: 84%

Polymorphisms of interleukin‐1 and interleukin‐2 genes in patients with gastric cancer in Korea

Shin¹,

Jang²,

Kim³

et al. 2008

J of Gastro and Hepatol

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Background and Aim: Interleukin (IL)-1 gene polymorphism has been reported to be associated with the increment of gastric cancer (GC) and the decrement of duodenal ulcers (DU). In addition, IL-2 is known to induce Helicobacter pylori (H. pylori)-associated gastric atrophy, but it is not known whether IL-2 gene polymorphism increases the risk of GC (GC) or peptic ulcer diseases. Therefore, we compared the genotypes of IL-1B, IL-1RN, and IL-2 gene polymorphisms with risk of gastric ulcers (GU), GC, and DU in Korean patients. Methods: In total, 116 GU, 122 GC, and 104 DU patients were included consecutively and compared with 100 healthy controls. Polymorphisms of the IL-1B-511/-31 gene, the pentaallelic variable number of tandem repeats of the IL-1RN gene, and the IL-2-330 gene were analyzed by polymerase chain reaction with restriction fragment length polymorphism or confronting two-pair primers methods. There was also no significant difference in the genotypes of these cytokine polymorphisms between the study group (GU or DU) and control group. In addition, genotypic frequency was not associated with H. pylori positivity and histological type of GC. Conclusion: IL-1B-511, IL-1RN, and IL-2 genetic polymorphisms were not important contributors to the pathogenesis of GU, GC, and DU in Korean patients.

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“…The frequency of the IL-10 − 1082G allele in our population (4%) was similar to that in Korean (7.4%) [19] and Japanese (6.5%) populations [20], but was significantly different from that reported in Caucasians (48%) [21]. The present results also show that the genotype frequency of the IL-10 − 1082A allele was significantly increased in TB patients compared with the LTBI subjects, especially when it was associated with the IFN-γ +874A allele (OR = 3.59; p = 0.045).…”

Section: Discussionsupporting

confidence: 83%

Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case–control study

et al. 2015

BMC Immunol

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BackgroundPolymorphisms in cytokine genes are known to influence cytokine levels, which may influence susceptibility to tuberculosis (TB) infection and disease. Differences in cytokine expression probably determine whether TB progresses, resolves, or becomes latent. In particular, the balance between the Th1 and Th2 cytokine responses influences the expression of disease in individuals with pulmonary TB (PTB). We performed a case–control study of 120 patients diagnosed with PTB, 240 with latent TB infection (LTBI), and 480 healthy controls (HC), to explore the association between polymorphisms in cytokine genes and a predisposition to Mycobacterium tuberculosis infection and TB disease.ResultsA single-gene analysis showed a dominant association between the AA genotype or A allele at nucleotide −874 of the interferon γ (IFN-γ) gene and LTBI. The A allele at nucleotide −1082 of the interleukin 10 (IL-10) gene was significantly more common in PTB patients than in LTBI subjects. Moreover, the polymorphisms at IFN-γ −874 and IL10 − 1082 were associated with protein levels of IFN-γ and IL-10, respectively, in the PTB group. The genotype frequencies of other polymorphisms did not differ between the PTB patients, LTBI and HC subjects. Furthermore, combinations of polymorphisms with IFN-γ −874 were associated with LTBI, whereas combinations with IL10 − 1082 were more likely associated with PTB.ConclusionsThere are positive associations between the IFN-γ −874 polymorphism and TB and between the IL10 − 1082 polymorphism and LTBI. Our data provide genetic evidence of the multiple disease hypothesis that many cytokine genes are involved in TB susceptibility.

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Polymorphisms of IL-1B, IL-1RN, IL-2, IL-4, IL-6, IL-10, and IFN-γ genes in the Korean population

Cited by 54 publications

References 69 publications

Ethnic Variation in Interleukin-6 –174 (G/C) Polymorphism in the Malaysian Population

Ethnic Variation in Interleukin-6 –174 (G/C) Polymorphism in the Malaysian Population

Polymorphisms of interleukin‐1 and interleukin‐2 genes in patients with gastric cancer in Korea

Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case–control study

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