Polymorphisms of VDR gene and risk of gastric cardiac adenocarcinoma in Chinese population

Abstract

Vitamin D receptor (VDR) gene polymorphisms have been reported to increase susceptibility to some malignant tumors, yet the effect on gastric cardiac adenocarcinoma susceptibility remains unknown. Here, we conducted a hospital-based case-control study to examine the correlation of single nucleotide polymorphisms of VDR rs2107301T>C, rs2228570C>T, rs1989969C>T and rs11568820 G>A and gastric cardiac adenocarcinoma susceptibility. A total 330 cases and 608 controls were enrolled in the study. Using ligation detection reaction, we found that the variant alleles of the four polymorphisms were not associated with risk of gastric cardiac adenocarcinoma. Further stratified analyses showed that there was an increased risk associated with VDR rs1989969 polymorphism among patients who were drinking or aged <60. The haplotypes VDR Trs2107301Trs2228570Crs1989969Grs11568820 reduced the susceptibility. This study demonstrated that VDR rs1989969 polymorphism was involved in the carcinogenesis of gastric cardiac adenocarcinoma, especially increased the risk in the younger and alcohol drinking Chinese population.

Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment

“…Polymorphisms in genes related with vitamin D metabolism, including VDR , CYP27A1 , CYP27B1 , CYP24A1 and GC , have been associated with cancer risk and progression, and may function as a valuable factor in cancer prognosis. Here, we summarized the epidemiological and genetic studies performed in recent years depicting the association of gene polymorphisms with cancer risk, progression and prognosis in Table 257, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119.…”

A clinical metabolomics‑based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma

“…Systems biology and high-throughput screening methods have revealed that the incidence of GCA is associated with mutations in tumor protein P53 (18,19) and the vitamin D receptor (20), as well as polymorphisms in the Fas ligand gene (21) and thymidylate synthase (22). In addition, proteins such as cancer antigen 125 and minichromosome maintenance 5 serve as potential biomarkers for the early diagnosis of GCA (23,24).…”