Polymorphisms of HLA-DM genes in Japanese patients with psoriasis vulgaris

Saeki, Hidehisa; Nakagawa, Hidemi; Asahina, Akihiko; Tamaki, Kunihiko; Shibata, Yoichi; Kuwata, Shoji

doi:10.1046/j.1365-2133.1999.02929.x

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…West and Reed (1999) reported that the frequencies of DMA n 0103 and DMB n 0102 were increased in patients with juvenile dermatomyositis. Saeki et al (1999) reported that the frequency of DMA n 0102 was increased, and that of DMA n 0101 was decreased, in Japanese psoriasis patients, but no signi¢cant association between DMB alleles and psoriasis was shown. To determine the association between HLA-DM polymorphisms and psoriasis in the Korean population, we investigated the HLA-DM polymorphisms, and found the frequency of DMA n 0102 to be signi¢cantly increased and DMA n 0101/0101 and DMB n 0103/ 0103 to be decreased in psoriasis patients (Table II).…”

Section: Discussionmentioning

confidence: 98%

Association of TAP and HLA-DM Genes with Psoriasis in Koreans

Pyo

Hur

Kim

et al. 2003

Journal of Investigative Dermatology

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To investigate the possible involvement of antigen-processing genes in the pathogenesis of psoriasis, we analyzed the polymorphisms of the TAP1, TAP2, LMP2, LMP7, DMA, and DMB genes in 98 Korean psoriasis patients and compared them with 184 healthy controls. The frequencies of TAP2*B/B [relative risk (RR)=3.6, p<0.0002] and TAP2*B (RR=1.7, p<0.05) were significantly increased, but TAP1*B (RR=0.3, p<0.002) and TAP2*A (RR=0.6, p<0.03) were significantly decreased, in the patients compared to the controls. We performed further analysis on the TAP1 and TAP2 single nucleotide polymorphisms and found significant differences between the patients and controls in TAP1 single nucleotide polymorphism at position 637 and in TAP2 at 665. In HLA-DM, DMA*0102 (RR=2.5, p<0.0003) was significantly increased, but DMA*0101/0101 (RR=0.4, p<0.0004) and DMB*0103/0103 (RR= 0.3, p<0.005) were significantly decreased in the patients compared to the controls. The TAP and HLA-DM alleles were also analyzed according to the age of onset of psoriasis in the patients (types I and II). It was found that the HLA-DM alleles showed a greater association in type I than type II patients. An analysis of the linkage disequilibrium and stratification also indicated that the alleles of TAP and HLA-DM might be independently associated with HLA-Cw*0602 in psoriasis patients. The stratification analysis between DMA*0101/0101 and DMB*0103/0103 showed that a certain factor, controlled by a gene located between DMA and DMB, might provide strong protection against psoriasis, independently of Cw*0602, in our Korean population. In conclusion, our data suggest that the TAP and HLA-DM alleles could lead to genetic susceptibility toward psoriasis in Koreans.

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Section: Discussionmentioning

confidence: 98%

Association of TAP and HLA-DM Genes with Psoriasis in Koreans

Pyo

Hur

Kim

et al. 2003

Journal of Investigative Dermatology

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The Complexity of HLA Class II (DRB1, DQB1, DM) Associations With Disseminated Mycobacterium Avium Complex Infection Among HIV-1–Seropositive Whites

Naik

LeBlanc²,

Tang

et al. 2003

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Earlier associations of polymorphism in classic HLA class II (DRB1 and DQB1) genes have been extended to include the accessory genes DMA and DMB as determinants of disseminated Mycobacterium avium complex (DMAC) infection among HIV-1-seropositive whites. From the Multicenter AIDS Cohort study, 176 DMAC cases were matched with 176 controls in a nested case-control study. PCR-based HLA genotyping techniques were used to resolve variants of DRB1 and DQB1 to their four-digit or five-digit alleles, and single-strand conformation polymorphism was used to resolve sequences in exon 3 at each DM locus. The DMA*0102 allele occurred less frequently among DMAC cases than among controls (OR = 0.46, p =.02). Combinations of DRB1 alleles with or without specific DMA and DMB variants showed significant differences in distributions between the cases and controls, but both of the previously associated class II alleles (DRB1*1501 and DRB1*0701) showed stronger positive associations with DMAC in the absence than in the presence of DMA*0102. Apparent joint effects of DRB1 and DM allelic combinations on occurrence and timing of DMAC suggest that class II disease relationships may be better predicted by biologically plausible interactive combinations than by polymorphisms in individual genes.

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Polymorphisms of HLA-DM genes in Japanese patients with psoriasis vulgaris

Cited by 2 publications

References 18 publications

Association of TAP and HLA-DM Genes with Psoriasis in Koreans

Association of TAP and HLA-DM Genes with Psoriasis in Koreans

The Complexity of HLA Class II (DRB1, DQB1, DM) Associations With Disseminated Mycobacterium Avium Complex Infection Among HIV-1–Seropositive Whites

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