Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study

Abstract

Noise-induced hearing loss (NIHL) is the second-most frequent form of sensorineural hearing loss. When exposed to the same noise, some workers develop NIHL while others do not, suggesting that NIHL may be associated with genetic factors. To explore the relationship between single nucleotide polymorphisms (SNPs) in heat shock protein 70 (HSP70) genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility to NIHL in Han Chinese workers exposed to noise, a case-control association study was carried out with 286 hearing loss cases and 286 matched with gender, age, type of work, and exposure time, drawn from a population of 3790 noise-exposed workers. Four SNPs were selected and genotyped. Subsequently, the effects of the alleles and genotypes of the three HSP70 genes (HSPA1A, HSPA1B and HSPA1L) on NIHL were analyzed by using a conditional logistic regression. A generalized multiple dimensionality reduction (GMDR) was applied to further detect an interaction between the four SNPs. Compared with the combined genotypes CC/TC, carriers of the TT genotype of rs2763979 appeared to show greater susceptibility to NIHL (P = 0.042, adjusted OR = 1.731, 95% CI 1.021–2.935). A significant interaction between rs2763979 and CNE was found (P = 0.029), and a significant association was found between TT of s2763979 and NIHL (P = 0.024, adjusted OR = 5.694, 95%CI 1.256-25.817) in the 96 dB (A)≤CNE<101 dB (A) group. The results suggest that the rs2763979 locus of the HSP70 genes may be associated with susceptibility to NIHL in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets.

Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis

“…An increased expression of HSP70 has been found in cochlea cells under noise exposure and they further act as a protective factor in the development of NIHL [ 12 ]. What is noteworthy is that some studies indicated a close association between several SNPs in HSP70 genes, including rs1043618 [ 13 , 14 ], rs2763979 [ 15 ], rs2227956 [ 14 , 15 ], and rs1061581 [ 14 ] (the characteristics of these SNPs are listed in Table 1 ), and NIHL susceptibility, whereas no positive result for rs1043618, rs2227956 and rs1061581 was found in Yang‘s study [ 16 ]. For each SNP site, the conclusion in different studies is also diverse.…”

The Effect of a High-Frequency-Hearing-Threshold Weighted Value on the Diagnosis of Occupational-Noise-Induced Deafness

“…The traditional method for the early diagnosis of noise-induced hearing loss is Cys/Cys genotype, and the sensitivity of the rs2763979 locus [14] [15]. The results of twin studies showed that monozygotic pairs were more similar with regards to noise sensitivity than dizygotic pairs, and quantitative genetic modeling indicated significant familiality.…”

NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles Interactively Affect the Risk of Noise-Induced Hearing Loss

“…Increasing evidence has shown the association of susceptibility genes, such as catalase (CAT), heat shock protein70 (HSP70), cadherin-23 (CDH23), caspase (CASP), and NADPH oxidase3 (NOX3), with the development of NIHL [12][13][14][15][16][17][18]. Additionally, previous studies have demonstrated that smoking, stressful lifestyle, and physical exercise are associated with hearing loss [19][20][21].…”