Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)

Santovito, Alfredo; Burgarello, Claudio; Cervella, Piero; Delpero, Massimiliano

doi:10.1590/s1415-47572010005000059

Cited by 10 publications

(9 citation statements)

References 24 publications

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“…The frequencies of GSTT1 deletion in our populations were higher than that described for Europeans, including British (18%) [20], French (16%) [21], German (13%) [22] and Austrian (20%) [23], as well as for other Middle Eastern populations, including Turks (17.3%) [24], and Iranians (21.2%) [25], but was significantly lower than SouthEast Asians, such as Chinese (56.5%) [26], Koreans (53.8%) [27] and Japanese (44%) [28]. The frequencies of GSTT1 null genotype in our Arab populations are similar to that of the sub-Saharan Africans: Zimbabweans (26%) [30], Gambians (37.1%) [31], Cameroonians (46.8%) [32] and Ivory Coast (33.1%) [33] (Table 2). The difference of GTSM1 and GSTT1 null alleles' frequency between our samples and those of others is attributed to their evolutionary histories, and also to selection arising from varied exposures to toxic substances.…”

Section: Discussionsupporting

confidence: 47%

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Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

et al. 2011

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Abstract. Deletion polymorphisms for the glutathione S-transferase (GST) gene are associated with increased risk of cancer, and are implicated in detoxifying mutagenic electrophilic compounds. GST Polymorphic variants were reported for different populations. The aim of this study was to investigate the frequencies of GSTM1 and GSTT1 null genotypes among Bahraini, Lebanese and Tunisian Arabs. GST genotyping was done by multiplex PCR-based methods. Study subjects comprised 167 Bahrainis, 141 Lebanese and 186 Tunisians unrelated healthy individuals. GSTM1 deletion homozygosity of 49.7%, 52.5% and 63.4% were recorded for Bahraini, Lebanese and Tunisians, respectively. Among Bahrainis, the prevalence of GSTT1 null homozygotes was 28.7%, while in higher rates were seen in Lebanese (37.6%) and Tunisians (37.1%). Our results indicate that there are no major differences in allelic distribution of GSTM1 and GSTT1 genes between the three Arab populations investigated except between Bahrainis and Tunisians regarding the allelic distribution of GSTM1 gene (P = 0.013). Combined analysis of both genes revealed that 14.4% of Bahrainis, 16.3% of Lebanese and 21.0% of Tunisians harbor the deleted genotype of both genes. This is the first study that addresses GST gene polymorphism in Bahraini and Lebanese Arabs, and will help genetic studies on the association of GSTM1 and GSTT1 polymorphisms with disease risks and drug effects in Arab populations.

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Section: Discussionsupporting

confidence: 47%

“…Significant differences in GSTM1 null genotype distribution were seen with respect to Indians (20.7%) [29], and Africans, including Zimbabweans (24%) [30], Gambians (20.2%) [31], Cameroonians (27.8%) [32], and Ivory Coast (36.1%) [33] (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

et al. 2011

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“…The GSTT1 null allele frequency in Native Russians is very close to allelic frequencies observed in some European populations (Baysal et al, 2008). GSTT1 null allele in Ouangolodougou, a north Ivory Coast population, is significantly higher (33.1%) than in Chinese, Japanese and Pakistani populations (Santovito et al, 2010;Shaikh et al, 2010). In the HapMap CEU population, it was demonstrated that the SNP rs2266633 (Asp141Asn) is the "tagging SNP" of the GSTT1 homozygous deletion (Zhao et al, 2009).…”

Section: Discussionsupporting

confidence: 56%

Gene Frequencies of the Human GSTT1 (Null Allele) and GSTP1 (Ile105Val) Polymorphisms among South Indian Populations

Lakkakula¹,

Maram²,

Gurramkonda³

et al. 2013

ACRT

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Background: Glutathione S-transferases (GSTs) are members of the phase II biotransformation enzymes that play a key role in cellular detoxification of chemical carcinogens and xenobiotics. Variations at GST genes have been reported in different human populations, and some association studies have reported increased risk for cancers and other disease end points. The present study was conducted to investigate the allele frequency variations in south Indian populations.

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“…In this study, we found that the distribution of GSTM1-null, GSTT1-null, and GSTP1 in women and men were statistically comparable, p > 0.05 (Table 1). Santovito et al, reported similar results from north Ivory Coast regarding the distribution of GSTM1-null and GSTT1-null [24]. This finding may support the hypothesis that women and men probably have similar detoxification capabilities when exposed to xenobiotics.…”

Section: Discussionmentioning

confidence: 58%

Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population

et al. 2019

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Glutathione S-transferase genes, known to be highly polymorphic, are implicated in the process of phase II metabolism of many substrates, including xenobiotics, anticancer and anti-infective drugs. The detoxification activity is linked to individual genetic makeup. Therefore, the identification of alleles and genotypes in these genes within a population may help to better design genetic susceptibility and pharmacogenetic studies. We performed the present study to establish the frequencies of the GSTM1, GSTT1, and GSTP1 c. 313A > G (rs1695) polymorphisms in 206 individuals of the Malian healthy population. GSTM1 and GSTT1 were genotyped by using multiplex polymerase chain reaction, whereas genotypes of GSTP1 were identified by polymerase chain reaction followed by restriction fragment length polymorphism. The frequencies of GSTM1-null and GSTT1-null genotypes were respectively 24.3 and 41.3%. The observed genotype frequencies for GSTP1 were 25.73% homozygous wild-type AA, 49.03% heterozygous AG and 25.24% homozygous mutant GG. The frequency of GSTP1-A allele was 50.24% versus 49.76% for the GSTP1-G allele. The distribution of these three genes was homogeneous between men and women (p > 0.05). We found no statistical association between the presence of a particular profile of GSTM1 or GSTT1 with the genotypes of GSTP1 (p > 0.05). Nevertheless, we noticed that the majority of the individuals harboring the GSTM1-present or the GSTT1-present harbor also the GSTP1-AG genotype. In addition, the triple genotype GSTM1present/GSTT1-present/AG was the most frequent with 25.2%. Our findings will facilitate future studies regarding genetic associations of multifactorial diseases and pharmacogenetic, thus opening the way to personalized medicine in our population.

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Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)

Cited by 10 publications

References 24 publications

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Three Distinct Arab Populations

Gene Frequencies of the Human GSTT1 (Null Allele) and GSTP1 (Ile105Val) Polymorphisms among South Indian Populations

Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population

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