Gene Frequencies of the Human GSTT1 (Null Allele) and GSTP1 (Ile105Val) Polymorphisms among South Indian Populations

Lakkakula, Saikrishna; Maram, Rajasekhar; Gurramkonda, Venkatesh Babu; Pathapati, Ram Mohan; Visweswara, Subrahmanyam Battaram; Lakkakula, Bhaskar V.K.S.

doi:10.5171/2013.784869

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…The frequency of the GSTP1 polymorphism varies across different populations, as shown in the International Haplotype Map (HapMap) project (The International HapMap Consortium, 2003). Specifically, it has been reported that the allele frequency of Ile varies from 50% to 63% for the four African populations: African ancestry in the Southwest United States, Luhya in Webuye, Kenya, Maasai in Kinyawa, Kenya, and Yoruba in Ibadan, Nigeria (Lakkakula et al, 2013). We recently reported that the allele frequency of Ile is 51% for the Jamaican population (Rahbar et al, 2014c).…”

Section: Introductionmentioning

confidence: 99%

Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Rahbar

Samms‐Vaughan

et al. 2015

Research in Autism Spectrum Disorders

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We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2–8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [Matched Odds Ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted.

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Section: Introductionmentioning

confidence: 99%

Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Rahbar

Samms‐Vaughan

et al. 2015

Research in Autism Spectrum Disorders

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“…Glutathione S-transferases is an important family of Phase II enzymes that catalyze the detoxification of active metabolites of tobacco carcinogens. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

The synergy of tobacco and alcohol and glutathione S-transferase θ 1 gene deletion and oral squamous cell carcinoma

Mello¹,

Bavle

Paremala

et al. 2016

J Oral Maxillofac Pathol

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Background:Oral squamous cell carcinoma (OSCC) is the leading cancer among males in India. It is related to tobacco habits and alcohol consumption as well as the individual susceptibility for xenobiotic metabolizing enzyme polymorphisms. Glutathione S-transferase θ 1 (GSTT1) is a Phase II metabolic enzyme which is directly involved in catalyzing chemicals to mutagenic intermediates. This gene is characterized by genetic polymorphism resulting in complete gene deletion and subsequent absence of the enzyme, which ultimately dictates the risk of cancer development. Scraping buccal mucosa to obtain DNA from the cells is a simple, readily acceptable and rapid method to detect and assess the gene.Aim:To assess GSTT1 gene deletion in individuals giving a history of tobacco smoking and/or chewing and alcohol consumption and absence of clinically detectable lesions; and in OSCC cases to gauge if GSTT1 gene deletion confers protection to an individual and whether it can be used as a “single” marker to arrive at this conclusion. To validate the use of buccal scrape for determining the genotype of an individual by assessing the polymorphism at GSTT1 gene locus (22q11.2).Materials and Methods:Fifty-two cases were evaluated using buccal mucosal scrapes of tobacco habituates for 8 or more years, without clinically evident lesion (Group I) and from mucosa of tobacco habituates with clinically evident and histopathologically confirmed OSCC (Group II). DNA extraction and genotype at GSTT1 gene locus was determined by polymerase chain reaction assay.Statistical Analysis:The results were statistically analyzed using Chi-square test.Results:90.66% of subjects had GSTT1 null genotype in Group I subjects. In Group II, subjects with both clinically and histopathologically diagnosed oral cancer, about 76.96% had GSTT1 null genotype.Conclusion:GSTT1 null genotype confers protection to individuals with tobacco habits and alcohol consumption, predominantly to those who used chewable form of tobacco and especially among female population. However, the influence of many other environmental, genetic and epigenetic factors should be considered for the genesis/occurrence of cancer.

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Glutathione S-transferase M1 and T1 null genotype frequency distribution among four tribal populations of western India

Suthar

Purkait

Uttaravalli

et al. 2018

J Genet

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Glutathione S transferase (GST) family is a key contributor in the detoxification mechanism of our body.Deletion of the genes within this family has been reported in the failure of detoxification system, to some extent leading to various types of cancers and other life threatening diseases. The existing data and reports on the association of null genotype of both GSTM1 and GSTT1 genes for various diseases are inconsistent. But knowledge of the polymorphic distributions of genotypes in different populations is important for investigating the risk factors in different epidemiological studies. The present study thus aims to determine thefrequency of GSTM1 and GSTT1 null genotype frequency among four tribal groups, i.e. Mina, Garasia, Damor and Saharia of western India. A comparative analysis with different tribal as well as world population has also been undertaken to have a view of its worldwide frequency distribution. Our results reveal a frequency distribution varying from 22.6% to 66.9% with respect to GSTM1gene polymorphism and from 19.1% to 33.0% with respect to GSTT1 gene in the studied populations. To the best of our knowledge this is the first report on the GSTM1and GSTT1frequency distribution among the tribal population of western India and our study shows that the Mina tribal population has the highest frequency of GSTM1.

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Gene Frequencies of the Human GSTT1 (Null Allele) and GSTP1 (Ile105Val) Polymorphisms among South Indian Populations

Cited by 4 publications

References 40 publications

Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

The synergy of tobacco and alcohol and glutathione S-transferase θ 1 gene deletion and oral squamous cell carcinoma

Glutathione S-transferase M1 and T1 null genotype frequency distribution among four tribal populations of western India

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